Impact of antirecurrent therapy with antigestagens for uterine fibroids on the breast in reproductive-aged women
Objective. To evaluate the impact of antirecurrent therapy for uterine fibroids with the use of gynestril (mifepristone 50 mg) on the breast in reproductive-aged women.Novikova V.A., Penzhoyan G.A., Khorolsky V.A., Skladanovskaya T.V., Ponomarev V.V.
Subjects and methods. Examinations were made in 110 reproductive-aged women who received antirecurrent therapy with gynestril (mifepristone) at a dose of 50 mg per day in continuous mode for 3 months after laparoscopic myomectomy. Benign breast dysplasia (BBD) was diagnosed based on general clinical examination, check-up, palpation, and ultrasonography of the breast in all the patients before and after gynestril administration, and three months later.
Results. Breast examination revealed that prior to gynestril use, 61.82% of the women had subjective signs (mastalgia, mastodynia) of BBD that was objectively verified by ultrasonography in 47.27% of the patients. The use of gynestril was ascertained to be associated with a significant (p < 0.05) decline in the number of women with subjective signs of BBD: from 61.85 to 30% after completion of 3-month therapy and to 31.82% 3 months after treatment termination and in that of women with objective signs of diffuse breast changes: from 40.91 to 21.82% after completion of 3-month therapy and to 19.84% 3 months later.
Conclusion. It was established that there was a significant decrease in the detection rate of BBD predominantly as a diffuse form during antirecurrent therapy with gynestril for uterine fibroids.
Keywords
benign breast diseases
dyshormonal breast diseases
mastalgia
mastodynia
breast cancer prevention
mifepristone
gynestril
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Received 10.02.2017
Accepted 17.02.2017
About the Authors
Novikova Vladislava, MD, professor of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Postgraduate Education,Kuban State Medical University. 350063, Russia, Krasnodar, Sedina str. 4. Tel.: +79183506237. E-mail: vladislavan@mail.ru
Penzhoyan Grigory Artemovich, Doctor of Medical Sciences, Professor, Head of the Department of Obstetrics, Gynecology and Perinatology,
Faculty of Advanced Studies and Postgraduate Training of Specialists, Kuban State Medical University.
350063, Russia, Krasnodar, Sedina str. 4. Tel.: +78612220114. E-mail: Pga05@mail.ru
Khorolsky Vadim, associate professor of the Department of Obstetrics, Gynecology and Perinatology, Faculty of Postgraduate Education,
Kuban State Medical University. 350063, Russia, Krasnodar, Sedina str. 4. Tel.: +79882486199. E-mail: vadim23_67@mail.ru
Skladanovskaya Tatyana V., associate professor of the Department of Obstetrics and Gynecology and Perinatology, Faculty of Postgraduate Education,
Volgograd State Medical University. 400131, Russia, Volgograd, Pavshikh Bortsov Sq. 1. Tel.: +79023853205. E-mail: yanechka2000@yandex.ru
Ponomarev Vladislav Viktorovich, Doctor of Medical Sciences, Professor of the Department of Obstetrics, Gynecology and Perinatology,
Faculty of Advanced Studies and Postgraduate Training of Specialists. 350063, Russia, Krasnodar, Sedina str. 4. E-mail: 11vik@mail.ru
For citations: Novikova V.A., Penzhoyan G.A., Khorolsky V.A., Skladanovskaya T.V., Ponomarev V.V. Impact of antirecurrent therapy with antigestagens for uterine fibroids on the breast in reproductive-aged women. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (4): 108-13. (in Russian)
http://dx.doi.org/10.18565/aig.2017.4.108-13
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