Treatment for cyclic mastodynia in patients with benign breast diseases
Kravchenko E.N., Naboka M.V., Sosnin I.M., Tsygankova M.V.
Objective: To evaluate the efficacy of indole carbinol medication (Indinol Forto) in treating benign breast dysplasia (BBD).
Materials and methods: The study included 274 women aged 29–52 years who presented with complaints of breast pain: group A consisted of 109 women with BBD (BI-RADS 2) who were prescribed complex treatment with indole carbinol-based medication; group B included 79 patients with BBD (BI-RADS 3) who underwent surgery followed by complex treatment with indole carbinol-based medication; group C consisted of 86 women with BBD (BI-RADS 2) who refused to receive medical treatment.
Results: At the end of the six-month course of treatment with indole carbinol, there was a significant improvement in health and a decrease or disappearance of mastalgia: only 8.3% of women in group A (p1<0.001), 12.6% of women in group B (p2<0.001), and 76.7% of women in group C had complaints of mastodynia. Mild mammographic density was noted in 74.3% of patients in group A, in 72.3% of women in group B and in 46.5% of patients in group C (p1<0.001, p2<0.001); moderate density was noted in 20.1%, 19.0% and 32.6% of patients (p1=0.050, p2=0.048), respectively; severe density was noted in 3.7%, 3.8% and 12.8% of women (p1=0.018, p2=0.039), respectively; very severe density was noted in 1.8%, 1.3% and 8.1% of patients (p1=0.038, p2=0.041), respectively.
Conclusion: Indole carbinol medication may be recommended for widespread use as a first-line medication in women with increased breast density.
Authors’ contributions: Kravchenko E.N. – developing the concept and design of the study, analysis of the results, writing the text, editing the article, approval of the final version of the article; Naboka M.V., Sosnin I.M., Tsygankova M.V. – collecting and processing the material, analysis and interpretation of the data and treatment results, writing the text.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Ethical Approval: The study was approved by the Ethical Review Board of the Omsk State Medical University, Ministry of Health of Russia.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Kravchenko E.N., Naboka M.V., Sosnin I.M., Tsygankova M.V. Treatment for cyclic mastodynia in patients with benign breast diseases.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (3): 124-131 (in Russian)
https://dx.doi.org/10.18565/aig.2024.42
Keywords
benign breast dysplasia
mastodynia
mastalgia
mastopathy
indole carbinol
Indinol Forto
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Received 29.02.2024
Accepted 12.03.2024
About the Authors
Elena N. Kravchenko, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology No. 1, Omsk State Medical University, Ministry of Health of Russia, 644043, Russia, Omsk, Lenin str., 12, +7(3812)23-02-93, +7(913)620-81-62, kravchenko.en@mail.ruMaxim V. Naboka, Assistant, Department of Oncology, Radiation Therapy, Omsk State Medical University, Ministry of Health of Russia, 644099, Russia, Omsk, Lenin str., 12; oncologist at the Center for Outpatient Oncological Care, Clinical Medical Unit No. 7, 644053, Russia, Omsk, Tvarkovsky str., 8, +7(3812)60-17-46, +7(913)976-16-64, nabokamax@mail.ru
Maxim I. Sosnin, oncologist, Head of the Day Hospital of the Oncological Department of Drug Antitumor Therapy, Odintsovo Regional Hospital, 143003, Russia, Moscow Region, Odintsovo, Marshal Biryuzov str., 3, +7 (999) 453-86-94, maxim.nervik@gmail.com
Maria V. Tsygankova, 2nd year clinical resident with a degree in oncology, N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia,
197758, Russia, St. Petersburg, pos. Pesochny, Leningradskaya str., 68, +7(913)973-84-38, tsygankovva98@mail.ru
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