Hyaluronic acid-enriched embryo transfer medium in assisted reproductive technology programs: mechanism of action and indications for use

Romanov A.Yu., Makarova N.P., Dolgushina N.V., Kalinina E.A.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow
The paper carries out a systems analysis of the data available in the current literature on the use of hyaluronic acid-enriched embryo transfer medium to improve the outcomes of assisted reproductive technology (ART) programs. It describes possible mechanisms of action of the hyaluronic acid-enriched embryo transfer medium in the ART programs. Separate attention is paid to the definition of indications for this procedure.How to manage patients with a history of multiple failed IVF attempts has not been definitively determined today. One of the reasons for the failure to implant high-grade quality embryos is the lack of adhesive matrix formation between the embryo and the endometrium. The use of hyaluronic acid-enriched embryo transfer media can be an innovative non-invasive procedure to overcome the problem of implantation failure in ART programs. Older female reproductive age, low-grade quality embryos, and a history of multiple failed IVF attempts are indications for this procedure. Nonetheless, the results of studies in this area are currently extremely controversial.

Keywords

embryo transfer
assisted reproductive technologies
hyaluronic acid

References

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Received 26.03.2018

Accepted 20.04.2018

About the Authors

Romanov, Andrey Yu., clinical resident, National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare of the Russian Federation.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +7903158-94-00. E-mail: romanov1553@yandex.ru
Makarova, Nataliya P., PhD, Researcher of the ART department, National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
of the Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: np_makarova@oparina4.ru
Dolgushina, Nataliya Vitalievna, M.D., Ph.D., M.P.H., Head of R&D Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology
Ministry of Healthcare of the Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: n_dolgushina@oparina4.ru
Kalinina, Elena A., M.D., Ph.D., Head of IVF Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology Ministry
of Healthcare of the Russian Federation. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: e_kalinina@oparina4.ru

For citations: Romanov A.Yu., Makarova N.P., Dolgushina N.V., Kalinina E.A. Hyaluronic acid-enriched embryo transfer medium in assisted reproductive technology programs: mechanism of action and indications for use. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (12): 12-6. (in Russian)
http://dx.doi.org/10.18565/aig.2018.12.12-16

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