Embryo cultivation in the medium containing granulocyte-macrophage colony-stimulating factor in the ART programs

1. Zegers-Hochschild F., Adamson G.D., de Mouzon J., Ishihara O., Mansour R., Nygren K. et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil. Steril. 2009; 92(5): 1520-4.
2. Назаренко Т.А., Мишеев Н.Г., ред. Бесплодие и возраст. Пути решения проблемы. М.: МЕДпресс-информ; 2014. [Nazarenko T.A., Misheev N.G., ed. Infertility and age. Ways to solve the problem. M .: MEDpress-inform; 2014. (in Russian)]
3. Das M., Holzer H.E. Recurrent implantation failure: gamete and embryo factors. Fertil. Steril. 2012; 97(5): 1021-7.
4. Коньков Д.Г., Мазорчук Б.Ф., Процепко А.А., Таран О.А., Шевня Л.И., Бунец П.Н. Современные аспекты этиологии, патогенеза и диагностики неразвивающейся беременности. В кн.: Труды Крымского ГМУ. 2008; 144(ч. IV): 134-40. [Konkov D.G., Mazorchuk B.F., Protsepko A.A., Taran O.A., Shevnya L.I., Bunets P.N. Modern aspects of the etiology, pathogenesis and diagnosis of non-developing pregnancy. In the book: Proceedings of the Crimean State Medical University. 2008; 144 (part IV): 134–40. (in Russian)]
5. Митюрина Е.В., Перминова С.Г., Амян Т.С. Причины повторных неудач имплантации в программе экстракорпорального оплодотворения. Акушерство и гинекология. 2016; 11: 34-40. [Mityurina E.V., Perminova S.G., Amyan T.S. Causes of repeated implantation failures in the in vitro fertilization program. Obstetrics and gynecology. 2016; 11: 34-40. (in Russian)]
6. Dosiou C., Giudice L.C. Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives. Endocr. Rev. 2005; 26(1): 44-62.
7. Malina A., Pooley J.A. Psychological consequences of IVF fertilization – review of research. Ann. Agric. Environ. Med. 2017; 24(4): 554-8.
8. Evans J., Hannan N.J., Hincks C., Rombauts L.J., Salamonsen L.A. Defective soil for a fertile seed? Altered endometrial development is detrimental to pregnancy success. PloS One. 2012; 7(12): e53098.
9. Huang P., We L., Qin A. Effects of intrauterine perfusion of human chorionic gonadotropin in women with different implantation failure numbers. Am. J. Reprod. Immunol. 2018; 79(2): e12809.
10. Fox C., Morin S., Jeong J.W., Scott R.T. Jr., Lessey B.A. Local and systemic factors and implantation: what is the evidence? Fertil. Steril. 2016; 105(4): 873-84.
11. Рудакова Е.Б., Давыдов П.В., Давыдов В.В. Диагностика внутриматочной патологии при подготовке к экстракорпоральному оплодотворению. Лечащий врач. 2015; 1: 83-6.
12. Enciso M., Carrascosa J.P., Sarasa J., Martínez-Ortiz P.A., Munné S., Horcajadas J.A., Aizpurua J. Development of a new comprehensive and reliable endometrial receptivity map (ER Map/ER Grade) based on RTqPCR gene expression analysis. Hum. Reprod. 2018; 10 Jan.
13. Robertson S.A., Chin P.Y., Femia J.G., Brown H.M. Embryotoxic cytokines - Potential roles in embryo loss and fetal programming. J. Reprod. Immunol. 2018; 125: 80-8.
14. Kannampuzha-Francis J., Denicol A.C., Loureiro B., Kaniyamattam K., Ortega M.S., Hansen P.J. Exposure to colony stimulating factor 2 during preimplantation development increases postnatal growth in cattle. Mol. Reprod. Dev. 2015; 82: 892-7.
15. Громенко Ю.Ю., Исхаков И.Р. Влияние факторов оценки качества перенесенных эмбрионов на прогнозирование частоты наступления беременности в программах экстракорпорального оплодотворения. Медицинский вестник Башкортостана. 2012; 7(2): 27-30.
16. Moldenhauer L.M., Keenihan S.N., Hayball J.D., Robertson S.A. GM-CSF is an essential regulator of T cell activation competence in uterine dendritic cells during early pregnancy in mice. J. Immunol. 2010;185(11): 7085-96.
17. Guerin L.R., Prins J.R., Robertson S.A. Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum. Reprod. Update. 2009; 15(5): 517-35.
18. Sferruzzi-Perri A.N., Macpherson A.M., Roberts C.T., Robertson S.A. Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol. Reprod. 2009; 81(1): 207-21.
19. Martinez-Moczygemba M., Huston D.P. Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF. J. Allergy Clin. Immunol. 2003; 112(4): 653-65.
20. Robertson S.A. GM-CSF regulation of embryo development and pregnancy. Cytokine Growth Factor Rev. 2007; 18(3-4): 287-98.
21. Hamilton J.A., Anderson G.P. GM-CSF biology. Growth Factors. 2004; 22(4): 225-31.
22. Ziebe S., Loft A., Povlsen B.B., Erb K., Agerholm I., Aasted M. et al. A randomized clinical trial to evaluate the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) in embryo culture medium for in vitro fertilization. Fertil. Steril. 2013; 99(6): 1600-9.
23. Tevkin S., Lokshin V., Shishimorova M., Polumiskov V. The frequency of clinical pregnancy and implantation rate after cultivation of embryos in a medium with granulocyte macrophage colony-stimulating factor (GM-CSF) in patients with preceding failed attempts of ART. Gynecol. Endocrinol. 2014; 30(Suppl. 1): 9-12.
24. Zhou W., Chu D., Sha W., Fu, Li Y. Assist effects of granulocyte-macrophage colony-stimulating factor supplementation in culture medium on embryo quality and pregnancy outcome of women aged over 35 years. Reprod. Genet. 2016; 33(1): 39-47.
25. Тевкин С.И., Шишиморова М.С., Локшин В.Н. Культивирование эмбрионов в среде, содержащей гранулоцитарно – макрофагальный колониестимулирующий фактор (GM-CSF), у пациентов различных возрастных групп. В кн.: Репродуктивные технологии сегодня и завтра. Материалы XXIV Международной конференции Российской Ассоциации Репродукции Человека (3-6 сентября 2014 г., Ярославль). М.; 2014: 46-9.
26. Бурлев В.А., Ильясова Н.А., Онищенко А.С., Кузьмичев Л.Н. Системные и локальные изменения L-селектина и лиганда МЕКА-79 при трубном бесплодии в программах ЭКО/ИКСИ. Проблемы репродукции. 2013; 19(6): 43-50.
27. Gardner D.K., Wale P.L., Collins R., Lane M. Glucose consumption of single post-compaction human embryos is predictive of embryo sex and live birth outcome. Hum. Reprod. 2011; 26(8): 1981-6.
28. Botros L., Sakkas D., Seli E. Metabolomics and its application for non-invasive embryo assessment in IVF. Mol. Hum. Reprod. 2008;14(12): 679-90.
29. Hickman C.F., Ainslie A., Ealy A.D., Ashworth C.J. Rooke J.A. Effect of ovine granulocyte-macrophage colony-stimulating factor on bovine in vitro embryo development and blastocyst Interferon-τ secretion. Reprod. Domest. Anim. 2011; 46: 608-15.
30. Rødgaard T., Heegaard P.M., Callesen H. Non-invasive assessment of in-vitro embryo quality to improve transfer success. Reprod. Biomed. Online. 2015; 31(5): 585-92.
31. Li X., Xu Y., Fu J., Zhang W.B., Liu S.Y., Sun X.X. Non-invasive metabolomic profiling of embryo culture media and morphology grading to predict implantation outcome in frozen-thawed embryo transfer cycles. J. Assist. Reprod. Genet. 2015; 32: 1597-1605.

Received 13.04.2018

Accepted 20.04.2018