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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2019№9
Cryopreservation of reproductive material in...

Cryopreservation of reproductive material in cancer patients

DOI
https://dx.doi.org/10.18565/aig.2019.9.40-49

Nazarenko T.A., Burduli A.G., Martirosyan Ya.O., Dzhanashvili L.G.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
The review includes data from foreign and Russian articles published in the past years and found in PubMed on the topic under consideration. It discusses the current state of the problem of preserving reproductive material in young cancer patients. The review underlines the need to expand and intensify investigations of oncofertility due to the growing clinical need and the unresolved nature of many tasks. The paper considers the proposed techniques to protect the ovaries before chemotherapy and radiotherapy and up-to-date procedures to obtain and preserve oocytes and embryos, defines ovarian stimulation protocols, and evaluates their effectiveness and safety. There are data on experimental directions in this area and on prospects for their use in clinical practice.

Keywords

cancer patients
preservation of reproductive material
oncofertility
cryopreservation
oocytes
embryos
ovarian tissue
autotransplantation
in vitro maturation
Full text (in Russian)

References

  1. https://www.cancer.gov/about-cancer/understanding/statistics
  2. https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancer-diagnosis/breast-cancer-survival-rates.html
  3. Lindegaard J.C. et al. The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology Guidelines for the Management of Patients With Cervical Cancer. International Journal of Gynecological Cancer. 2018; 28: 641-655.
  4. Loren A.W., Mangu P.B., Beck L.N., Brennan L., Magdalinski A.J., Partridge A.H., Quinn G., Wallace W.H., Oktay K. Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. Journal of Clinical Oncology. 2013; 31: 2500-2510.
  5. ACOG Committee Opinion No. 747. Obstetrics & Gynecology. 2018; 132(2): e67-e77.
  6. Lambertini M., Horicks F., Del Mastro L., Partridge A.H., Demeestere I. Ovarian protection with gonadotropin-releasing hormone agonists during chemotherapy in cancer patients: From biological evidence to clinical application. Cancer Treatment Reviews. 2019; 72: 65-77.
  7. Demeestere I., Brice P., Peccatori F.A., Kentos A., Dupuis J., Zachee P., Casasnovas, O., Van Den Neste E., Dechene J., De Maertelaer V., et al. No evidence for the benefit of gonadotropin-releasing hormone agonist in preserving ovarian function and fertility in lymphoma survivors treated with chemotherapy: Final long-term report of a prospective randomized trial. Journal of Clinical Oncology. 2016; 34: 2568-2574.
  8. Roness H., Kashi O., Meirow D. Prevention of chemotherapy-induced ovarian damage. Fertility and Sterility. 2016; 105: 20-29.
  9. Moawad N.S., Santamaria E., Rhoton-Vlasak A., Lightsey J.L. Laparoscopic Ovarian Transposition Before Pelvic Cancer Treatment: Ovarian Function and Fertility Preservation. Journal of Minimally Invasive Gynecology. 2017; 24; 28-35.
  10. Arian S.E., Goodman L., Flyckt R.L., Falcone T. Ovarian transposition: a surgical option for fertility preservation. Fertil Steril. 2017; 107(4): e15.
  11. Gubbala K., Laios A., Gallos I., Pathiraja P., Haldar K., Ind T. Outcomes of ovarian transposition in gynaecological cancers; a systematic review and meta-analysis. Journal of ovarian research. 2014; 7; 69.
  12. von Wolff M., Germeyer A., Liebenthron J., Korell M., Nawroth F. Practical recommendations for fertility preservation in women by the FertiPROTEKT network. Part II: fertility preservation techniques. Arch Gynecol Obstet. 2017; 297(1): 257-267.
  13. Franasiak J.M., Forman E.J., Hong K.H., Werner M.D., Upham K.M., Treff N.R., Scott R.T. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Fertility and Sterility. 2014; 101 (3): 656-663.
  14. Takai Y. Recent advances in oncofertility care worldwide and in Japan. Reproductive medicine and biology. 2018; 17(4); 356-368.
  15. García-Velasco J., Domingo J., Cobo A., Remohí J., Pellicer A. Elective and Onco-fertility preservation: factors related to IVF outcomes. Human Reproduction. 2018; 33: 2222-2231.
  16. Rajabi Z., Aliakbari F., Yazdekhasti H. Female Fertility Preservation, Clinical and Experimental Options. Journal of reproduction & infertility. 2018; 19(3): 125-132.
  17. Назаренко Т.А., Сухих Г.Т., Мишиева Н.Г. Бесплодие и возраст. М.:МедПресс-Информ, 2014; 266 с.[Nazarenko T.A., Suhih G.T., Mishieva N.G. Besplodie i vozrast. M.:MedPress-Inform, 2014; 266 s.(In Russian)]
  18. Weinberg M., Dirnfeld M. Fertility Preservation and Women’s Hopes- The Dilemmas of Social Egg Freezing. Ann Infert Rep Endocrin. 2018; 1(1): 1001.
  19. Cardozo E.R., Thomson A.P., Karmon A.E., Dickinson K.A., Wright D.L., Sabatini ME. Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls: a 17-year experience. J Assist Reprod Genet. 2015; 32(4):587-96.
  20. Mature oocyte cryopreservation: a guideline. Fertility and Sterility. 2012; 99(1): 37-43.
  21. Rabadan S., Cobo A., Martinez M., Garcia-Velasco J.A., Pellicer A., Domingo J. Obstetric outcome after oocyte vitrification and warming for fertility preservation in women with cancer. Reproductive BioMedicine Online. 2014; 29: 722-728.
  22. Kato K. Vitrification of embryos and oocytes for fertility preservation in cancer patients. Reprod Med Biol. 2016, 15: 227-233.
  23. Stillman R.J., Richter K.S., Tucker M.J., Graham J.R., Doyle J.O., Lim J. Successful elective and medically indicated oocyte vitrification and warming for autologous in vitro fertilization, with predicted birth probabilities for fertility preservation according to number of cryopreserved oocytes and age at retrieval. Fertility and Sterility. 2015; 105: 459-466.e2
  24. Coello A., Cobo A., García-Velasco J.A., Remohí J., Domingo J., Pellicer A. Oocyte vitrification as an efficient option for elective fertility preservation. Fertility and Sterility. 2015; 105: 755-764.e8.
  25. Lawrenz B., Jauckus J., Kupka M., Strowitzki T., Von Wolff M. Efficacy and safety of ovarian stimulation before chemotherapy in 205 cases. Fertility and Sterility. 2010; 94: 2871-2873.
  26. Alvarez R.M., Ramanathan P. Fertility preservation in female oncology patients: The influence of the type of cancer on ovarian stimulation response. Human Reproduction. 2018; 33: 2051-2059.
  27. Domingo J., Guillén V., Ayllón Y., Martínez M., Muñoz E., Pellicer A., Garcia-Velasco J.A. Ovarian response to controlled ovarian hyperstimulation in cancer patients is diminished even before oncological treatment. Fertility and Sterility. 2012; 97: 930-934.
  28. Boots C.E., Meister M., Cooper A.R., Hardi A., Jungheim E.S. Ovarian stimulation in the luteal phase: systematic review and meta-analysis. J Assist Reprod Genet. 2016; 33(8): 971-80.
  29. Kuang Y., Hong Q., Chen Q., Lyu Q., Ai A., Fu Y., Shoham Z. Luteal-phase ovarian stimulation is feasible for producing competent oocytes in women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment, with optimal pregnancy outcomes in frozen-thawed embryo transfer cycles. Fertility and Sterility. 2014; 101: 105-111.
  30. Chen H., Wang Y., Lyu Q., Ai A., Fu Y., Tian H., Cai R., Hong Q., Chen Q., Shoham Z., et al. Comparison of live-birth defects after luteal-phase ovarian stimulation vs. conventional ovarian stimulation for in vitro fertilization and vitrified embryo transfer cycles. Fertility and Sterility. 2015; 103:1194-1201.e2.
  31. de Ziegler D., Wolf J.P., Moffat R., Pirtea P., Gayet V., Chapron C. Dual ovarian stimulation is a new viable option for enhancing the oocyte yield when the time for assisted reproductive technnology is limited. Reproductive BioMedicine Online. 2014; 29: 659-661.
  32. Klock S.C., Zhang J.X., Kazer R.R. Fertility preservation for female cancer patients: early clinical experience. Fertility and Sterility. 2010; 94: 149-155.
  33. Quintero R.B., Helmer A., Huang J.Q., Westphal L.M. Ovarian stimulation for fertility preservation in patients with cancer. Fertility and Sterility. 2010; 93: 865-868.
  34. Almog B., Azem F., Gordon D., Pauzner D., Amit A., Barkan G., Levin I. Effects of cancer on ovarian response in controlled ovarian stimulation for fertility preservation. Fertility and Sterility. 2012; 98; 957-960.
  35. Robertson A.D., Missmer S.A., Ginsburg, E.S. Embryo yield after in vitro fertilization in women undergoing embryo banking for fertility preservation before chemotherapy. Fertility and Sterility. 2011; 95, 588–591.
  36. Quinn M.M., Cakmak H., Letourneau J.M., Cedars M.I., Rosen M.P. Response to ovarian stimulation is not impacted by a breast cancer diagnosis. Human Reproduction. 2017; 32: 568-574.
  37. Turan V., Quinn M.M., Dayioglu N., Rosen M.P., Oktay K. The impact of malignancy on response to ovarian stimulation for fertility preservation: a meta-analysis. Fertility and Sterility. 2018; 110: 1347-1355.
  38. Creux H., Monnier P., Son W.Y., Buckett, W. Thirteen years’ experience in fertility preservation for cancer patients after in vitro fertilization and in vitro maturation treatments. Journal of Assisted Reproduction and Genetics. 2018; 35: 583-592.
  39. Назаренко Т.А., Шарипова Н.Ю., Пароконная А.А. и соавт. Возможности сохранения генетического материала у больных раком молочной железы. Вестник РОНЦ им. Н.Н. Блохина РАМН. 2011; 22 (1).[Nazarenko T.A., Sharipova N.Ju., Parokonnaja A.A. i soavt. Vozmozhnosti sohranenija geneticheskogo materiala u bol'nyh rakom molochnoj zhelezy. Vestnik RONC im. N.N. Blohina RAMN. 2011; 22 (1).(In Russian)]
  40. Ben-Haroush A., Wertheimer A., Klochendler E., Sapir O., Shufaro Y., Oron G. Effect of letrozole added to gonadotropins in controlled ovarian stimulation protocols on the yield and maturity of retrieved oocytes. Gynecological Endocrinology. 2018; Dec 31: 1-4.
  41. Oktay K., Hourvitz A., Sahin G., Oktem O., Safro B., Cil A., Bang H. Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy. Journal of Clinical Endocrinology and Metabolism . 2006; 91: 3885-3890.
  42. Oktay K., Turan V., Bedoschi G., Pacheco F. S., Moy F. Fertility Preservation Success Subsequent to Concurrent Aromatase Inhibitor Treatment and Ovarian Stimulation in Women With Breast Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015; 33(22): 2424-9.
  43. Van Den Belt-Dusebout A.W., Spaan M., Lambalk C.B., Kortman M., Laven J.S.E., Van Santbrink E.J.P., Van Der Westerlaken L.A.J., Cohlen B.J., Braat D.D.M., Smeenk J.M.J., et al. Ovarian stimulation for in vitro fertilization and long-term risk of breast cancer. JAMA – Journal of the American Medical Association . 2016; 316: 300-312.
  44. Rodgers R. J., Reid G. D., Koch J., Deans R., Ledger W. L., Friedlander M., Gilchrist R. B., Walters K.A., Abbott J. A.. The safety and efficacy of controlled ovarian hyperstimulation for fertility preservation in women with early breast cancer: a systematic review . Human Reproduction. 2017; 32 (5): 1033-1045.
  45. Lim K.S., Chae S.J., Choo C.W., Ku Y.H., Lee H.J., Hur C.Y., Lim J.H., Lee W.D. In vitro maturation: Clinical applications. Clinical and experimental reproductive medicine. 2013; 40(4): 143-7.
  46. Lu C., Zhang Y., Zheng X. et al. Sci. China Life Sci. 2018; 61: 633.
  47. Khalili M.A., Shahedi A., Ashourzadeh S., Nottola S.A., Macchiarelli G., Palmerini M.G. Vitrification of human immature oocytes before and after in vitro maturation: a review. Journal of assisted reproduction and genetics. 2017; 34(11): 1413-1426.
  48. Cao Y.X., Chian R.C. Fertility preservation with immature and in vitro matured oocytes. Semin Reprod Med. 2009; 27: 456-464.
  49. Roesner S., von Wolff M., Eberhardy I., Beuter-Winkler P., Toth B., Strowitzki T. In vitro maturation: a five‐year experience. Acta Obstetricia et Gynecologica Scandinavica. 2012; 91: 22-27.
  50. Huang J.Y.J., Tulandi T., Holzer H., Tan S.L., Chian R.C. Combining ovarian tissue cryobanking with retrieval of immature oocytes followed by in vitro maturation and vitrification: an additional strategy of fertility preservation. Fertility and Sterility. 2008; 89: 567-572.
  51. Park C.W., Lee S.H., Yang K.M., Lee I.H., Lim K.T., Lee K.H., Kim T.J. Cryopreservation of in vitro matured oocytes after ex vivo oocyte retrieval from gynecologic cancer patients undergoing radical surgery. Clinical and experimental reproductive medicine. 2016; 43(2): 119-25.
  52. Sarma U., Findlay J.K., Hutt K. Oocytes from stem cells. Best Practice & Research Clinical Obstetrics & Gynaecology. 2018; 55: 14-22.
  53. Smitz J.E.J., Gilchrist R.B. Are human oocytes from stem cells next? Nature Biotechnology. 2016; 34: 1247-1248.
  54. Oktay K., Harvey B.E., Partridge A.H., Quinn G.P., Reinecke J., Taylor H. S., Loren A.W. Fertility preservation in patients with cancer: ASCO clinical practice guideline update. Journal of Clinical Oncology. 2018; 36(19:1994-2001.
  55. Andersen C.Y., Kjærsgaard M., Ernst E., Birkebæk N.H., Clausen N. Case report: Stimulation of puberty in a girl with chemo- and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue. European Journal of Cancer. 2012; 49: 911-914.
  56. von Wollf M., Stute P. Cryopreservation and transplantation of ovarian tissue exclusively to postpone menopause: technically possible but endocrinologically doubtful. Reprod Biomed Online. 2015; 31: 718-721
  57. Masciangelo R., Bosisio C., Donnez J., Amorim C.A., Dolmans M.M. Safety of ovarian tissue transplantation in patients with borderline ovarian tumors. Human Reproduction. 2018; 33; 212-219.
  58. Man L., Park L., Bodine R., Ginsberg M., Zaninovic N., Schattman G., Schwartz R. E., Rosenwaks Z., James D. Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery. J. Vis. Exp. 2018; (135): e57472.
  59. Donnez J., Desmet C.M., Manavella D.D., Cacciottola L., Jordan B.F., Amorim C.A., Dolmans M.M. Adipose tissue-derived stem cells in a fibrin implant enhance neovascularization in a peritoneal grafting site: a potential way to improve ovarian tissue transplantation. Human Reproduction. 2017; 33: 270-279.

Received 25.03.2019

Accepted 19.04.2019

About the Authors

Tatiana A. Nazarenko, MD, Professor, Director of the Research and educational center for assisted reproductive technologies named after F. Paulsen-senior, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. Tel.: 8(495)5314444.
E-mail: t.nazarenko@mail.ru
117997, Russia, Moscow Ac. Oparina Street 4.
Anna G. Burduli, MD, Candidate of Medical Science, Senior researcher in IVF department named after B.V. Leonov in National Medical Research Center of Obstetrics, Gynecology and Perinatology Ministry of Health of Russia. Tel.: 8(495)5314444. E-mail: burdulianna@gmail.com
117997, Russia, Moscow Ac. Oparina Street 4.
Yana O. Martirosyan, clinical resident, National Medical Research Center of Obstetrics, Gynaecology, and Perinatology named after Academician V.I. Kulakov,
Ministry of Helth of Russia. Tel.: +79169500745. E-mail marti-yana@index.ru
117997, Russian, Moscow, Ac. Oparina str. 4.
Lana G. Dzhanashvili, fellow, National Medical Research Center of Obstetrics, Gynaecology, and Perinatology named after Academician V.I. Kulakov,
Ministry of Helth of Russia. Tel.: +79629185619 E-mail lana.janashvili@gmail.com
117997, Russian, Moscow, Ac. Oparina str. 4.

For citation: Nazarenko T.A., Burduli A.G., Martirosyan Ya.O., Dzhanashvili L.G. Cryopreservation of reproductive material in cancer patients.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 9: 40-9.(In Russian)
https://dx.doi.org/10.18565/aig.2019.9.40-49

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