Cryopreservation of reproductive material in cancer patients
The review includes data from foreign and Russian articles published in the past years and found in PubMed on the topic under consideration. It discusses the current state of the problem of preserving reproductive material in young cancer patients. The review underlines the need to expand and intensify investigations of oncofertility due to the growing clinical need and the unresolved nature of many tasks. The paper considers the proposed techniques to protect the ovaries before chemotherapy and radiotherapy and up-to-date procedures to obtain and preserve oocytes and embryos, defines ovarian stimulation protocols, and evaluates their effectiveness and safety. There are data on experimental directions in this area and on prospects for their use in clinical practice.Nazarenko T.A., Burduli A.G., Martirosyan Ya.O., Dzhanashvili L.G.
Keywords
cancer patients
preservation of reproductive material
oncofertility
cryopreservation
oocytes
embryos
ovarian tissue
autotransplantation
in vitro maturation
References
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Received 25.03.2019
Accepted 19.04.2019
About the Authors
Tatiana A. Nazarenko, MD, Professor, Director of the Research and educational center for assisted reproductive technologies named after F. Paulsen-senior, National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. Tel.: 8(495)5314444.E-mail: t.nazarenko@mail.ru
117997, Russia, Moscow Ac. Oparina Street 4.
Anna G. Burduli, MD, Candidate of Medical Science, Senior researcher in IVF department named after B.V. Leonov in National Medical Research Center of Obstetrics, Gynecology and Perinatology Ministry of Health of Russia. Tel.: 8(495)5314444. E-mail: burdulianna@gmail.com
117997, Russia, Moscow Ac. Oparina Street 4.
Yana O. Martirosyan, clinical resident, National Medical Research Center of Obstetrics, Gynaecology, and Perinatology named after Academician V.I. Kulakov,
Ministry of Helth of Russia. Tel.: +79169500745. E-mail marti-yana@index.ru
117997, Russian, Moscow, Ac. Oparina str. 4.
Lana G. Dzhanashvili, fellow, National Medical Research Center of Obstetrics, Gynaecology, and Perinatology named after Academician V.I. Kulakov,
Ministry of Helth of Russia. Tel.: +79629185619 E-mail lana.janashvili@gmail.com
117997, Russian, Moscow, Ac. Oparina str. 4.
For citation: Nazarenko T.A., Burduli A.G., Martirosyan Ya.O., Dzhanashvili L.G. Cryopreservation of reproductive material in cancer patients.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2019; 9: 40-9.(In Russian)
https://dx.doi.org/10.18565/aig.2019.9.40-49