Clinical and anamnestic factors and lifestyle features significantly influencing apical prolapse
Dubinskaya E.D., Gasparov A.S., Matskevich E.N., Babicheva I.A.
Objective: To evaluate lifestyle features and significant clinical and anamnestic factors associated with apical prolapse in parous women.
Materials and methods: A clinical retrospective case-control study analyzed medical records data of 230 patients with pelvic organ prolapse who underwent examination and treatment in the period from 2017 to 2024 at the University Clinic "I am healthy!" The main group was composed of 130 patients with apical prolapse, and the control group was composed of 100 patients without apical prolapse (with prolapse of the anterior and/or posterior vaginal wall).
Results: The analysis identified lifestyle features and clinical factors, which have statistically significant relationship with occurrence of apical prolapse: hard physical job, advanced age for a first birth, apical prolapse in first-degree relatives, prolonged labor for a first birth, weight gain during pregnancy and duration of postmenopause. Analysis determined threshold values of the indicators which increase the probability of occurrence of apical prolapse. Thus, the value of the weight gain of 13 kg during pregnancy was determined as a threshold value; the value exceeding this threshold was associated with increased probability of occurrence of apical prolapse by 4.15 times (odds ratio (OR)=4.15, 95% confidence interval (CI) 2.38–7.21, p<0.001). Duration of postmenopause for more than 7 years was determined as a threshold value; the value exceeding the threshold was associated with increased probability of occurrence of apical prolapse by 2.79 times (OR=2.79, 95% CI 1.63–4.77, p<0.001). Duration of labor in first-time mothers for more than 15.5 hours was determined as the threshold value; the value exceeding the threshold was associated with increased probability of occurrence of apical prolapse by 3.48 times (OR=3.48, 95% CI 2.02–6.00, p<0.001). The age for the first birth over 22 years was determined as a threshold value, the value exceeding the threshold was associated with increased probability of occurrence of apical prolapse by 9.57 times (OR=9.57, 95% CI 5.23–17.51, p<0.001).
Conclusion: This study made it possible to identify for the first time a number of clinical factors and the features of lifestyle, pregnancy, labor and duration of postmenopause associated with apical prolapse. The calculated threshold values and odds ratios for these factors may help understand and manage risk occurrence of apical prolapse in parous women.
Authors' contributions: Dubinskaya E.D., Gasparov A.S. – development of the concept and design of the study; Matskevich E.N., Babicheva I.A. – material collection and processing; Matskevich E.N., Dubinskaya E.D. – article writing; Dubinskaya E.D., Gasparov A.S., Matskevich E.N., Babicheva I.A. – article editing.
Conflicts of interest: The authors have no conflicts of interest to declare.
Funding: The study was carried out without any sponsorship.
Ethical Approval: The study was approved by the Local Ethics Committee of Patrice Lumumba Peoples' Friendship University of Russia.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Dubinskaya E.D., Gasparov A.S., Matskevich E.N., Babicheva I.A.
Clinical and anamnestic factors and lifestyle features significantly influencing apical prolapse.
Akusherstvo i Gynekologiya/Obstetrics and Gynecology. 2025; (3): 128-135 (in Russian)
https://dx.doi.org/10.18565/aig.2024.303
Keywords
apical prolapse
pelvic organ prolapse
factors significantly influencing apical prolapse
prolapse of posterior/anterior vaginal wall
lifestyle in vaginal prolapse
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Received 02.12.2024
Accepted 14.02.2025
About the Authors
Ekaterina D. Dubinskaya, Dr. Med. Sci., Professor at the Department of Obstetrics, Gynecology with Course of Perinatology, Patrice Lumumba Peoples’ Friendship University of Russia, 8 Miklukho-Maklaya str., Moscow, 117198, Russia, +7(903)117-55-58, eka-dubinskaya@yandex.ru, https://orcid.org/0000-0002-8311-0381Alexander S. Gasparov, Dr. Med. Sci., Professor, Department of Obstetrics, Gynecology with Course of Perinatology, Patrice Lumumba Peoples’ Friendship University
of Russia, 8 Miklukho-Maklaya str., Moscow, 117198, Russia, +7(903) 117-55-58, 13513520@mail.ru, https://orcid.org/0000-0001-6301-1880
Elizaveta N. Matskevich, Teaching Assistant at the Department of Obstetrics, Gynecology and Reproductive Medicine, Faculty of Continuing Medical Education,
Patrice Lumumba Peoples’ Friendship University of Russia, 5-2 General Antonov str., Moscow, 117342, Russia, +7(911)176-66-94, liza151196chik@mail.ru,
https://orcid.org/0009-0000-3315-7408
Irina A. Babicheva, PhD, Associate Professor at the Department of Obstetrics, Gynecology and Reproductive Medicine, Faculty of Continuing Medical Education,
Patrice Lumumba Peoples’ Friendship University of Russia, 8 Miklukho-Maklaya str., Moscow, 117198, Russia, +7(916)500-10-99, babicheva200751@mail.ru
Corresponding author: Ekaterina D. Dubinskaya, eka-dubinskaya@yandex.ru
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