Clinical significance of sFlt-1/PlGF in the diagnosis and prediction of preeclampsia

Guryeva V.M., Travkina A.A., Matveev M.O., Morokhotova L.S., Budykina T.S., Kotov Yu.B., Semenova T.A.

1) Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia; 2) Federal Research Center, M.V. Keldysh Institute of Applied Mathematics, Russian Academy of Sciences, Moscow, Russia; 3) National Research Nuclear University, Moscow Engineering and Physical Institute, Moscow, Russia
The diagnosis of preeclampsia in clinical practice causes certain difficulties due to the non-specificity of symptoms, the polymorphism of the clinical picture, and the discrepancy between the magnitude of clinical symptoms and the severity of multiple organ dysfunction. Therefore, the accurate diagnosis and prediction of preeclampsia is of great importance for practical obstetrics. The paper presents the results of the basic studies devoted to the clinical interpretation of the sFlt-1/PlGF ratio for the diagnosis and prediction of preeclampsia and shows the informative value and significance of the ratio for the objectification of the diagnosis of preeclampsia, as well as the possibility of predicting this obstetric complication according to sFlt-1/PlGF data. It shows the experience of using sFlt-1/PlGF in the obstetric service in the Moscow Region and formulates indications for the study of sFlt-1/PlGF in clinical practice and approaches to its interpretation.
Conclusion. The application of sFlt-1/PlGF allows the differential diagnosis of preeclampsia with an exacerbation or a manifestation of a number of somatic diseases that occur with similar clinical symptoms. The use of sFlt-1/PlGF provides an economic effect, by improving the routing and decreasing the number of severe perinatal and maternal outcomes, as well as reducing unjustified hospitalization. sFlt-1/PlGF is an informative marker for the diagnosis and prediction of preeclampsia and its adverse outcomes and can be recommended for use in clinical practice.

Keywords

preeclampsia
pregnancy
angiogenic factors
antiangiogenic factors
sFlt1/PlGF level

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Received 12.07.2021

Accepted 14.07.2021

About the Authors

Vera M. Guryeva, Dr. Med. Sci., Leading Researcher, Moscow Regional Scientific Research Institute of Obstetrics and Gynaecology.
Tel.: +7(926) 862-17-28; +7(495)623-00-97. E-mail: helgin99@gmail.com. 101000, Russia, Moscow, Pokrovka str., 22а.
Arina A. Travkina, PhD, Senior Researcher, Moscow Regional Scientific Research Institute of Obstetrics and Gynaecology.
Tel.: +7(917)573-22-93; +7(495)625-08-52. E-mail: arinamamba@mail.ru. 101000, Russia, Moscow, Pokrovka str., 22а.
Maxim O. Matveev, graduate student, Moscow Regional Scientific Research Institute of Obstetrics and Gynaecology.
Tel.: +7(968)210-00-62; +7(495)623-00-97. E-mail: max-mix@mail.ru. 101000, Russia, Moscow, Pokrovka str., 22а.
Ludmila S. Morokhotova, PhD, doctor, Moscow Regional Scientific Research Institute of Obststrics and Gynecology.
Tel.: +7(916)352-10-93; +7(495)625-08-52. E-mail: ludrikm1982@gmail.com. 101000, Russia, Moscow, Pokrovka str., 22а.
Yury B. Kotov, Dr. Sci. (Physics and Mathematics), Leading Researcher, Keldysh Institute of Applied Mathematics RAS.
Tel.: +7(919)773-27-22. E-mail: kobylazabyla11@yandex.ru. 125047, Russia, Moscow, Miusskaya sqr., 4.
Tatyana A. Semenova, PhD (Physics and Mathematics), Associate Professor, National Research Nuclear University, Moscow Engineering Physics Institute.
Tel.: +7(985)250-83-14. E-mail: kotsem@voxnet.ru. 115409, Russia, Moscow, Kashirskoye shosse, 31.

For citation: Guryeva V.M., Travkina A.A., Matveev M.O., Morokhotova L.S., Budykina T.S., Kotov Yu.B., Semenova T.A. Clinical significance of sFlt-1/PlGF in the diagnosis and prediction of preeclampsia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 7: 195-200 (in Russian).
https://dx.doi.org/10.18565/aig.2021.7.195-200

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