Clinical value of changes of the transmigration activity of leukocytes in the diagnosis of severe preeclampsia
Aim. To identify additional criteria for the diagnosis of severe preeclampsia (PE) in pregnant women based on an investigation of the expression of the early adhesion molecules, chemokine receptors, and markers of endothelial dysfunction in venous blood neutrophils and monocytes. Material and methods. One hundred and fifty patients with PE (74 with moderate PE, 76 with severe PE) and 70 women with a physiological course of pregnancy were tested for venous blood neutrophils and monocytes expressing adhesion molecules CD62L, CD11b, chemokine receptors CCR2 and CX3CR1, and the number of circulating endothelial cells (CECs). Results. When compared with women having uneventful pregnancy and patients with moderate PE, patients with severe PE had significantly lower levels of CD62L+neutrophils, but higher levels of CX3CR1+monocytes and neutrophils, and a greater number of CECs. The diagnostic thresholds for these parameters are informative in the diagnosis of PE severity. Conclusion. Measuring the relative levels of CD62L+, CX3CR1+ neutrophils and the number of CECs in the blood can be used for stratifying severity of PE with greater accuracy.Panova I.A., Kudryashova A.V., Rokotyanskaya E.A., Malyshkina A.I., Pareyshvili V.V., Bogatova I.K.
Keywords
pregnancy
preeclampsia
venous blood
diagnostic criteria
adhesion molecules
chemokine receptors
desquamated endotheliocytes
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Received 08.12.2017
Accepted 22.12.2017
About the Authors
Panova, Irina A., doctor of medical sciences, assistant professor, head of Department of obstetrics and gynecology, V.N. Gorodkov Ivanovo Research Instituteof Maternity and Childhood, Ministry of Health of Russia. 153045, Russia, Ivanovo, Pobedy str. 20. Tel.: +74932351862. E-mail:ia_panova@mail.ru
Kudryashova, Anna V., doctor of biological sciences, senior researcher of the laboratory of clinical immunology, V.N. Gorodkov Ivanovo Research Institute
of Maternity and Childhood, Ministry of Health of Russia. 153045, Russia, Ivanovo, Pobedy str. 20. Tel.: +74932336928. E-mail:niimid.immune@mail.ru
Rokotyanskaya Elena A., candidate of medical Sciences, assistant Professor of the Department of Obstetrics and Gynecology, Neonatology, Anesthesiology and Reanimatology, V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia.
153045, Russia, Ivanovo, Pobedy str. 20. Tel.: +74932351862. E-mail: rokotyanskaya.ea@mail.ru
Malyshkina Anna Ivanovna, doctor of medical sciences, Director, V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia.
153045, Russia, Ivanovo, Pobedy str. 20. Tel.: +74932338320. E-mail: ivniimid@inbox.ru
Pareyshvili Violetta Vasilevna, doctor of medical sciences, Professor of the Department of Obstetrics and Gynecology, Neonatology, Anesthesiology and Reanimatology,
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia.
153045, Russia, Ivanovo, Pobedy str. 20. Tel.: +74932351862. E-mail: ivniimid@inbox.ru
Bogatova Irina Konstantinovna, doctor of medical sciences, Professor, Chief Researcher of the Department of Obstetrics and Gynecology,
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia.
153045, Russia, Ivanovo, Pobedy str. 20. Tel.: +74932351862. E-mail: ivniimid@inbox.ru
For citation: Panova I.A., Kudryashova A.V., Rokotyanskaya E.A., Malyshkina A.I., Pareyshvili V.V., Bogatova I.K. Clinical value of changes of the transmigration activity of leukocytes in the diagnosis of severe preeclampsia.Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (8): 77-84. (in Russian)
https://dx.doi.org/10.18565/aig.2018.8.77-84
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