Clinical experience of successful treatment for radiation-induced breast angiosarcomas

Lubennikova E.V., Abramov M.E., Gutorov S.L., Trofimova O.P., Vishnevskaya Ya.V., Amosova V.A., Vyshinskaya G.V., Borisova E.I., Litvinov R.P., Valiev R.K., Frolova M.A., Petrovsky A.V.

N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia
Background. Radiation-induced breast angiosarcomas are an extremely rare disease characterized by a low response to available treatment options and by an unfavorable prognosis. The diagnosis is complex and requires histological and immunohistochemical verification.
Description. This paper describes three clinical cases of patients treated for radiation-induced angiosarcomas in the N.N. Blokhin National Research Center of Oncology.
Conclusion. The diagnosis and treatment of radiation-induced sarcomas remains a complex issue in modern oncology. The inclusion of these patients in clinical trials and even in the descriptions of individual clinical cases seems to be important steps towards finding an effective treatment for this pathology.

Keywords

angiosarcoma
breast cancer
breast sarcoma

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Received 01.11.2019

Accepted 29.11.2019

About the Authors

Elena V. Lubennikova, PhD, oncologist, oncology department of medicinal methods of treatment (chemotherapy) №3, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail lubennikova@yandex.ru, phone: +79150809357. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Michael E. Abramov, PhD, oncologist, oncology department of medicinal methods of treatment (chemotherapy) №3, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail abramovm67@mail.ru, phone: +79258229830.
115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Sergei L. Gutorov, MD, oncologist, oncology department of medicinal methods of treatment (chemotherapy) №3, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail s1gutorov@gmail.com, phone: +79031990606. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Oxana P. Trofimova, MD, oncologist, department of radiology Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail dr.trofimova@mail.ru, phone: +79031492976. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Yana V. Vishnevskaya, PhD, oncologist, pathology department, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, yana_vishn@list.ru; phone: +79161417563,115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Victoria A. Amosova, oncologist, surgical department №13, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, amosova_@mail.ru; phone: +79296560529, 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Galina V Vishinskaya, MD, oncologist, oncology department of medicinal methods of treatment (chemotherapy) №3, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, galina@userhost.ru , phone: +79250299641. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Elena I. Borisova, PhD, oncologist, oncology department of medicinal methods of treatment (chemotherapy) №3, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail: doctorborisova@ya.ru, phone: +79031991939. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Roman P. Litvinov, PhD, oncologist, surgical department №13, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail: litvinio-roman@mail.ru, phone: +79169997929. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Ramis K. Valiev, PhD, head of surgical department №13, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail: radiosurgery@bk.ru, phone: +79263592060. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Mona A. Frolova, PhD, oncologist, oncology department of medicinal methods of treatment (chemotherapy) №2, Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, e-mail: drfrolova@yandex.ru, phone: +79031990675. 115478 Russian Federation, Moscow, Kashirskoe sh., 23.
Alexander V. Petrovsky, PhD, Deputy Director of Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation, phone: +79035882480, alexpetrovsky@hotmail.com; 115478 Russian Federation, Moscow, Kashirskoe sh., 23.

For citation: Lubennikova E.V., Abramov M.E., Gutorov S.L., Trofimova O.P., Vishnevskaya Ya.V., Amosova V.A. , Vyshinskaya G.V., Borisova E.I., Litvinov R.P., Valiev R.K., Frolova M.A., Petrovsky A.V. Clinical experience of successful treatment for radiation-induced breast angiosarcomas.
Akusherstvo i Ginekologiya/Obstetrics and gynecology. 2019; 12: 207-15. (In Russian).
https://dx.doi.org/10.18565/aig.2019.12.207-215

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