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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2020№4
Use of cryopreserved embryos in...

Use of cryopreserved embryos in assisted reproductive technology programs

DOI
https://dx.doi.org/10.18565/aig.2020.4.195-200

Petrosyan Ya.A., Frolova A.M., Syrkasheva A.G.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Overall success rates for cryopreserved embryo transfer have increased over the past few years. The paper gives data on the higher efficiency of cryo protocols versus fresh in vitro fertilization (IVF) protocols. It demonstrates the greater contribution of cryopreserved embryo transfer to the total number of live births over the past decades. Moreover, clinical and embryological tactics during the IVF program using cryopreserved embryos are not clearly defined. The effectiveness of assisted embryological techniques in the transfer of cryopreserved embryos has not been studied. There is a high variability in the protocols for preparing the endometrium for cryotransfer, including differences in dose, routes of administration, duration of use of drugs, and the first day of progesterone administration. Despite a large number of studies in this area, all of them are retrospective. In addition, the cost-effectiveness of the widespread use of cyclic hormone therapy has not been investigated. All of the above necessitates further study of this problem.

Keywords

cryopreserved embryos
assisted reproductive technologies
in vitro fertilization
economic efficiency
progesterone
Full text (in Russian)

References

  1. Gook D.A., Edgar D.H. Cryopreservation of female reproductive potential. Best Pract. Res. Clin. Obstet. Gynaecol. 2019; 55: 23-36. https://dx.doi.org/10.1016/j.bpobgyn.2018.08.005.
  2. Pandian Z., Templeton A., Serour G., Bhattacharya S. Number of embryos for transfer after IVF and ICSI: a cochrane review. Hum. Reprod. 2005; 20(10): 2681-7.
  3. Edgar D.H., Gook D.A. A critical appraisal of cryopreservation (slow cooling versus vitrification) of human oocytes and embryos. Hum. Reprod. Update. 2012; 18(5): 536-54. https://dx.doi.org/10.1093/humupd/dms016.
  4. Долгушина Н.В., Ибрагимова Э.О., Романов А.Ю., Бурменская О.В., Макарова Н.П., Шафеи Р.А., Сыркашева А.Г. Предикторы эффективности спонтанного хетчинга бластоцист человека в программах вспомогательных репродуктивных технологий. Акушерство и гинекология. 2018; 2: 88-95. [Dolgushina N.V., Ibragimova E.O., Romanov A.Yu., Burmenskaya O.V., Makarova N.P., Shafei R.A., Syrkasheva A.G. Predictors of spontaneous human blastocyst hatching in ART programs. Obstetrics and Gynecology/Akusherstvo i ginekologiya. 2018; (2): 88-95. (in Russian).] https://dx.doi.org/10.18565/aig.2018.2.88-95.
  5. Groenewoud E.R., Cantineau A.E.P., Kollen B.J., Macklon N.S., Cohlen B.J. What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. Hum. Reprod. Update. 2017; 23(2): 255-61. https://dx.doi.org/10.1093/humupd/dmw046.
  6. Rienzi L., Gracia C., Maggiulli R., LaBarbera A.R., Kaser D.J., Ubaldi F.M. et al. Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance. Hum. Reprod. Update. 2017; 23(2): 139-55. https://dx.doi.org/10.1093/humupd/dmw038.
  7. Kaye L., Will E.A., Bartolucci A., Nulsen J., Benadiva C., Engmann L. Pregnancy rates for single embryo transfer (SET) of day 5 and day 6 blastocysts after cryopreservation by vitrification and slow freeze. J. Assist. Reprod. Genet. 2017; 34(7): 913-9. https://dx.doi.org/10.1007/s10815-017-0940-4.
  8. Somoskoi B., Kriston R., Cseh S., Konc J., Kanyo K. Cryopreservation of embryos and oocytes in human assisted reproduction. Biomed. Res. Int. 2014; 2014: 307268. https://dx.doi.org/10.1155/2014/307268.
  9. Kleinhans F.W., Mazur P. Comparison of actual vs. synthesized ternary phase diagrams for solutes of cryobiological interest. Cryobiology. 2007; 54(2): 212-22. https://dx.doi.org/10.1016/j.cryobiol.2007.01.007.
  10. Паращук В.Ю., Луцкий А.С., Грищенко Н.Г. Эффективность разных протоколов подготовки эндометрия при переносе витрифицированных/отогретых эмбрионов. Здоровье женщины. 2017; 2: 30. [Parashchuk V.Y., Lutsky A.S., Gryshchenko N.G. The effectiveness of different protocols of preparation of the endometrium when transferring vitrified/ warmed embryos.[ Health of Woman/ Zdorov’e zhenshchiny. 2017; 2: 30. (in Russian).]
  11. Li Z., Wang Y.A., Ledger W., Edgar D.H., Sullivan E.A. Clinical outcomes following cryopreservation of blastocysts by vitrification or slow freezing: a population-based cohort study. Hum. Reprod. 2014; 29(12): 2794-801. https://dx.doi.org/10.1093/humrep/deu246.
  12. Zeng M., Su S., Li L. The effect of laser-assisted hatching on pregnancy outcomes of cryopreserved-thawed embryo transfer: a meta-analysis of randomized controlled trials. Lasers Med. Sci. 2018; 33(3): 655-66. https://dx.doi.org/10.1007/s10103-017-2372-x.
  13. Ибрагимова Э.О., Долгушина Н.В., Сыркашева А.Г., Романов А.Ю., Языкова О.И., Макарова Н.П. Роль вспомогательного хетчинга в программах лечения бесплодия методами вспомогательных репродуктивных технологий: обзор литературы. Гинекология. 2016; 18(2): 44-7. [Ibragimova E.O., Dolgushina N.V., Syrkasheva A.G., Romanov A.Yu., Yazikova O.I., Makarova N.P. The role of assisted hatching in in vitro fertilization cycles: a literature review. Ginecology/Ginekologiya. 2016; 18(2): 44-7.(in Russian).]
  14. Syrkasheva A.G., Dolgushina N.V., Romanov A.Y., Burmenskaya O.V.,Makarova N.P., Ibragimova E.O., Kalinina E.A., Sukhikh G.T. Cell and genetic predictors of human blastocyst hatching success in assisted reproduction. Zygote. 2017; 25(5): 631-6. https://dx.doi.org/10.1017/S0967199417000508.
  15. Drakopoulos P., Mat C., Polyzos N.P., Santos-Ribeiro S., van de Vijver A., Van Landuyt L. et al. The impact of elevated progesterone on the initiation of an artificially prepared frozen embryo transfer cycle: a case series. Curr. Pharm. Biotechnol. 2017; 18(8): 619-21. https://dx.doi.org/10.2174/1389201018666170808125834.
  16. Quenby S., Brosens J.J. Human implantation: a tale of mutual maternal and fetal attraction. Biol. Reprod. 2013; 88(3): 81. https://dx.doi.org/10.1095/biolreprod.113.108886.
  17. Demir B., Dilbaz S., Cinar O., Ozdegirmenci O., Dede S., Dundar B., Goktolga U. Estradiol supplementation in intracytoplasmic sperm injection cycles with thin endometrium. Gynecol. Endocrinol. 2013;29(1): 42-5. https://dx.doi.org/ 10.3109/09513590.2012.705381.
  18. Kasius A., Smit J.G., Torrance H.L., Eijkemans M.J.C., Mol B.W., Opmeer B.C., Broekmans F.J. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis. Hum. Reprod. Update. 2014; 20(4): 530-41. https://dx.doi.org/10.1093/humupd/dmu011.
  19. Bu Z., Wang K., Dai W., Sun Y. Endometrial thickness significantly affects clinical pregnancy and live birth rates in frozen-thawed embryo transfer cycles. Gynecol. Endocrinol. 2016; 32(7): 524-8. https://dx.doi.org/10.3109/09513590.2015.1136616.
  20. Mahajan N., Kaur S., Alonso M.R. Window of implantation is significantly displaced in patients with adenomyosis with previous implantation failure as determined by endometrial receptivity assay. J. Hum. Reprod. Sci. 2018; 11(4): 353-8. https://dx.doi.org/ 10.4103/jhrs.JHRS_52_18.
  21. Park C.W., Choi M.H., Yang K.M., Song I.O. Pregnancy rate in women with adenomyosis undergoing fresh or frozen embryo transfer cycles following gonadotropin-releasing hormone agonist treatment. Clin. Exp. Reprod. Med. 2016; 43(3): 169-73. https://dx.doi.org/10.5653/cerm.2016.43.3.169.
  22. Halasz M., Szekeres-Bartho J. The role of progesterone in implantation and trophoblast invasion. J. Reprod. Immunol. 2013; 97(1): 43-50. https://dx.doi.org/10.1016/j.jri.2012.10.011.
  23. Kalem Z., Kalem M.N., Gurgan T. Methods for endometrial preparation in frozen-thawed embryo transfer cycles. J. Turk. Ger. Gynecol. Assoc. 2016; 17(3): 168-72. https://dx.doi.org/10.5152/jtgga.2016.15214.
  24. Kalem Z., Kalem M.N., Bakirarar B., Kent E., Gurgan T. Natural cycle versus hormone replacement therapy cycle in frozen-thawed embryo transfer. Saudi Med. J. 2018; 39(11): 1102-8. https://dx.doi.org/10.15537/smj.2018.11.23299.
  25. Bjuresten K., Landgren B.M., Hovatta O., Stavreus-Evers A. Luteal phase progesterone increases live birth rate after frozen embryo transfer. Fertil. Steril. 2011; 95(2): 534-7. https://dx.doi.org/10.1016/j.fertnstert.2010.05.019.
  26. Available at: https://www.focusonreproduction.eu/article/ESHRE-News-Freeze-all-2. 2019

Received 18.06.2019

Аccepted 21.06.2019

About the Authors

Yana A. Petrosyan, PhD student of the IVF Department. National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. E-mail: Yana_petrosyan86@mail.ru
4, Oparina str, Moscow, 117997, Russian Federation
Alexandra M. Frolova, embryologist of IVF Department. National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Tel.: +7(495) 438-77-00. E-mail: a_frolova@oparina4.ru
4, Oparina str, Moscow, 117997, Russian Federation
Anastasia G. Syrkasheva, M.D., Ph.D., Senior Researcher of the IVF Department/ National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Tel.: +7(926)363-17-20. E-mail: a_syrkasheva@oparina4.ru
4, Oparina str, Moscow, 117997, Russian Federation

For reference: Petrosyan Ya.A., Frolova A.M., Syrkasheva A.G. Use of cryopreserved embryos in assisted reproductive technology programs.
Akusherstvo i Ginekologiya (Obstetrics and Gynecology). 2020; 4: 195-200. (in Russian).
https://dx.doi.org/10.18565/aig.2020.4.195-200

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