Use of cryopreserved embryos in assisted reproductive technology programs

Petrosyan Ya.A., Frolova A.M., Syrkasheva A.G.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Overall success rates for cryopreserved embryo transfer have increased over the past few years. The paper gives data on the higher efficiency of cryo protocols versus fresh in vitro fertilization (IVF) protocols. It demonstrates the greater contribution of cryopreserved embryo transfer to the total number of live births over the past decades. Moreover, clinical and embryological tactics during the IVF program using cryopreserved embryos are not clearly defined. The effectiveness of assisted embryological techniques in the transfer of cryopreserved embryos has not been studied. There is a high variability in the protocols for preparing the endometrium for cryotransfer, including differences in dose, routes of administration, duration of use of drugs, and the first day of progesterone administration. Despite a large number of studies in this area, all of them are retrospective. In addition, the cost-effectiveness of the widespread use of cyclic hormone therapy has not been investigated. All of the above necessitates further study of this problem.


cryopreserved embryos
assisted reproductive technologies
in vitro fertilization
economic efficiency


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  26. Available at: 2019

Received 18.06.2019

Аccepted 21.06.2019

About the Authors

Yana A. Petrosyan, PhD student of the IVF Department. National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. E-mail:
4, Oparina str, Moscow, 117997, Russian Federation
Alexandra M. Frolova, embryologist of IVF Department. National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Tel.: +7(495) 438-77-00. E-mail:
4, Oparina str, Moscow, 117997, Russian Federation
Anastasia G. Syrkasheva, M.D., Ph.D., Senior Researcher of the IVF Department/ National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Tel.: +7(926)363-17-20. E-mail:
4, Oparina str, Moscow, 117997, Russian Federation

For reference: Petrosyan Ya.A., Frolova A.M., Syrkasheva A.G. Use of cryopreserved embryos in assisted reproductive technology programs.
Akusherstvo i Ginekologiya (Obstetrics and Gynecology). 2020; 4: 195-200. (in Russian).

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