The use of aromatase inhibitors for rapid relief of ovarian hyperstimulation symptoms occurring with an in vitro fertilization program
Background. Despite the rather low incidence of severe ovarian hyperstimulation syndrome (OHSS) in IVF programs, this complication during its severe course negatively affects the health of young women, requires intensive and long-term treatment, and leads to pregnancy complications. In this connection, the issues of rapid relief of OHSS symptoms are extremely relevant, especially in patients planning to start gonadotoxic therapy immediately after ovarian stimulation and oocyte retrieval.Martirosyan Ya.O., Nazarenko T.A., Korneeva I.E., Biryukova A.M.
Case report. There are two clinical cases describing and comparing the efficiency of using aromatase inhibitors and gonadotropin-releasing hormone antagonists (GnRH-ant) for the rapid relief of ovarian hyperstimulation symptoms.
Conclusion. The use of aromatase inhibitors versus GnRH-ant after transvaginal puncture contributes to a more rapid relief of the developed symptoms of ovarian hyperstimulation. It should be noted that the developed procedure is more cost effective than the use of GnRH-ant.
Keywords
ovarian hyperstimulation syndrome
aromatase inhibitors
GnRH antagonist
References
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Received 03.09.2020
Accepted 21.10.2020
About the Authors
Yana O. Martirosyan, junior researcher of the Scientific and Educational Center for ART with the Clinical Division named after F. Paulsen, Academician V.I. KulakovNational Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
Tel.: +7(925)124-99-99. E-mail: marti-yana@yandex.ru. ORCID: 0000-0002-9304-4410. 117997, Russian, Moscow, Ac. Oparina str., 4.
Tatiana A. Nazarenko, MD, PhD, Head of the Institute of Reproductive Technologies, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
Tel.: +7(915)322-08-79. E-mail: t.nazarenko@mail.ru. ORCID: 0000-0002-5823-1667. 117997, Russian, Moscow, Ac. Oparina str., 4.
Irina E. Korneeva, PhD, Head of SEC for ART named after F. Paulsen, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. Tel.: +7(495)438-26-22. E-mail: i_korneeva@oparina4.ru. ORCID: 0000-0002-8124-7659.
117997, Russian, Moscow, Ac. Oparina str., 4.
Almina M. Birukova, MD, Candidate of Medical Sciences, doctor is in charge of clinical work of the Scientific and Educational Center for ART with the Clinical Division named after F. Paulsen, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Health of Russia. E-mail: alma21@list.ru. 117997, Russian, Moscow, Ac. Oparina str., 4.
For citation: Martirosyan Ya.O., Nazarenko T.A., Korneeva I.E., Biryukova A.M. The use of aromatase inhibitors for rapid relief of ovarian hyperstimulation symptoms occurring with an in vitro fertilization program.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 11: 232-236 (in Russian).
https://dx.doi.org/10.18565/aig.2020.11.232-236
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