Incidence of endometrial hyperplastic processes in infertile women treated with in vitro fertilization
Objective: To clarify the frequency and pattern of intrauterine pathology in a non-selective cohort of patients participating in assisted reproductive technologies (ART) programs.Ershova I.Yu., Krasnopolskaya K.V., Orazov M.R., Fedorov A.A., Shostenko L.V.
Materials and methods: The frequency of intrauterine pathology was explored in 973 patients aged 23 to 44 years who had participated in ART programs. The diagnosis was finally verified with office or routine hysteroscopy and histomorphological examination. The incidence of endometrial hyperplastic processes (EHPs) in assessing its relationship to the use of previous treatment with ART was determined separately in groups of patients younger and older than 35 years.
Results: Intrauterine pathology was found in 38% of all the patients involved in ART programs. In patients with initially suspected uterine factor infertility, its frequency increased up to 68%. The pattern of verified intrauterine pathology predominated with EHPs, accounting for 44%.
Conclusion: In the non-selective population of patients participating in ART programs, the women with intrauterine pathology showed a preponderance of EHPs in its pattern, which manifested themselves as glandular hyperplasia and endometrial polyps.
Keywords
infertility
endometrial hyperplasia
ART programs
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Received 02.03.2022
Accepted 20.05.2022
About the Authors
Irina Yu. Ershova, PhD, Researcher at the Department of Reproduction, Moscow Regional Research Institute of Obstetrics and Gynecology,101000, Russia, Moscow, Pokrovka str., 22a; obstetrician-gynecologist, PRIOR CLINIC, 101000, Russia, Moscow, Potapovskiy pereulok, 4 b. 1, +7(495)980-40-28,
i3236987@gmail.com, https://orchid.org/0000-0001-9327-0656
Ksenia V. Krasnopolskaya, Corresponding Member of the RAS, Dr. Med. Sci., Professor, Head of the Department of Reproductology, Moscow Regional Research Institute of Obstetrics and Gynecology, 101000, Russia, Moscow, Pokrovka str., 22a; Head of the Department of High Reproductive Technologies, obstetrician-gynecologist,
PRIOR CLINIC, 101000, Russia, Moscow, Potapovskiy pereulok, 4 b. 1, +7(495)980-40-28, guzmoniiag@gmail.com, https://orchid.org/0000-0002-1275-9220
Mekan R. Orazov, Dr. Med. Sci., Professor, Professor at the Department of Obstetrics and Gynecology with a Course of Perinatology, RUDN University, +7(915)237-52-92, omekan@mail.ru, https://orcid.org/0000-0002-5342-8129, 117198, Russia, Moscow, Miklukho-Maklaya str., 10/3
Аnton А. Fedorov, Dr. Med. Sci., Leading Researcher at the Endoscopyc Surgery Department, Moscow Regional Research Institute of Obstetrics and Gynecology,
+7(495)625-73-32, gyn_endoscopy@mail.ru, 101000, Russia, Moscow, Pokrovka str., 22a.
Lidiya V. Shostenko, obstetrician-gynecologist, postgraduate student at the Department of Reproduction, Moscow Regional Scientific Research Institute of Obstetrics and Gynecology, +7(916)216-94-83, lidsonnn@gmail.com, https://orcid.org/0000-0001-5002-9344, 101000, Russia, Moscow, Pokrovka str., 22a.
Authors' contributions: Krasnopolskaya K.V. – concept and design of the investigation; Ershova I.Yu., Fedorov A.A. – material collection and processing; Shostenko L.V. – data processing; Krasnopolskaya K.V., Orazov M.R., Ershova I.Yu. – writing the text; Ershova I.Yu., Shostenko L.V. – editing.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
Ethical Approval: The investigation has been approved by the Ethics Committee of the Moscow Regional Research Institute of Obstetrics and Gynecology.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Ershova I.Yu., Krasnopolskaya K.V., Orazov M.R., Fedorov A.A., Shostenko L.V.
Incidence of endometrial hyperplastic processes in infertile women treated with in vitro fertilization.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 7: 114-120 (in Russian)
https://dx.doi.org/10.18565/aig.2022.7.114-120
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