Repeated implantation failures in an IVF program: Immunological aspects
Objective. To carry out a systematic analysis of the data available in modern literature on the immunological aspects of repeated implantation failures in an IVF program, as well as on current personalized immunotherapies to overcome repeated implantation failures.Amyan T.S., Perminova S.G., Krechetova L.V., Vtorushina V.V., Mityurina E.V.
Material and methods. The review includes the data of foreign and Russian papers published in 2010-2016 and found in Pubmed on this topic. These articles have become the basis for this review; however, for better understanding of the topic, the authors have expanded the search and included older articles that are widely cited.
Conclusion. There is substantial evidence that the impaired expression of nonclassical HLA molecules, cytokine imbalance, and changes in the number and activity of NK cells may contribute to reproductive dysfunction. A more complete understanding of hormonal modulation of the immune microenvironment of the endometrium will be able to elaborate new personalized therapeutic approaches to preventing repeated implantation failures.
Keywords
repeated implantation failures
nonclassical HLA molecules
NK cells
T regulatory cells
cytokine profile
Th1/Th2 balance
peripheral blood mononuclear cells
corticotropin-releasing hormone
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Received 26.08.2016
Accepted 02.09.2016
About the Authors
Amyan Tatiana S., a graduate student of the 1st year of study department of conservation and restoration of reproductive function, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4.Tel.: +79261632833. E-mail: amyantanya@rambler.ru
Perminova Svetlana G., MD, a leading researcher department of conservation and restoration of reproductive function, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79162021687. E-mail: perisvet@list.ru
Krechetova Lubov V., PhD, Senior Research Fellow, Head of the Laboratory Laboratory of Clinical Immunology, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: k_l_v_@mail.ru
Vtorushina Valentina V., PhD, doctor of clinical laboratory diagnostics, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: vtorushina@inbox.ru
Mityurina Elena V., Candidate of Medical Sciences, department of conservation and restoration of reproductive function, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4
For citations: Amyan T.S., Perminova S.G., Krechetova L.V., Vtorushina V.V., Mityurina E.V. Repeated implantation failures in an IVF program: Immunological aspects. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (1): 5-12. (in Russian)
http://dx.doi.org/10.18565/aig.2017.1.5-12
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