Gigantomastia: clinical cases, ultrasound characteristics

Sencha A.N., Gus A.I., Rodionov V.V., Shmakov R.G., Bikeev Yu.V., Kometova V.V., Gailish Yu.P.

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
The review highlights the issues showing the possibility of diagnosing gigantomastia, a rare breast disease of unknown origin and uncertain prognosis, and that of using the methods for its treatment and prognosis.
Material and methods. The review includes the results of cases of foreign and Russian meta-analyses found in Pubmed on this topic. The authors give their own observations, the clinical examples of the results of diagnosis and treatment, the use of the up-to-date ultrasound imaging technologies for different types of gigantomastia.
Results. The data obtained in the meta-analyses of studies, as well as the diagnostic characteristics of different types of gigantomastia were generalized, and the results of the authors’ own observations were analyzed. Ultrasound examination was shown to play a role in the primary, differential diagnosis and dynamic monitoring of patients with this pathology.
Conclusion. The findings, the above results, and their analysis just now and in the short term can be used as criteria for the diagnosis of gigantomastia in the clinical practice of physicians, mammologists, obstetricians/gynecologists, ultrasound diagnosticians, radiologists, endocrinologists, and oncologists, to largely determine further treatment policy and to predict outcomes.

Keywords

gigantomastia
breast
gestational form
ultrasound study
mastectomy
juvenile fibroadenoma

References

1. Dancey A., Khan M., Dawson J., Peart F. Gigantomastia - a classification and review of the literature. J. Plast. Reconstr. Aesth. Surg. 2008; 61: 493-502.

2. Moussaoui A., Kouach J., Ennouhi A., Babahabib A., Benabdejlil Y., Moussaoui D. et al. Idiopathic recurrent gigantomastia: a case report. J. Surg. 2014; 2(4): 54-7.

3. Тютюнник В.Л., Шифман Е.М., Параконная А.А., Балушкина А.А. Макромастия, манифистировавшая при беременности. Клинические наблюдения с двусторонней мастэктомией и благоприятным исходом. Акушерство и гинекология. 2012; 6: 81-4. [Tyutyunnik V.L., Shifman E.M., Parakonnaya A.A., Balushkina A.A. Macromastia of pregnancy: Clinical cases of bilateral mastectomy and a good outcome. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2012; 6: 81-4. (in Russian)]

4. Hoppe I.C., Patel P.P., Singer-Granick C.J., Granick M.S. Virginal mammary hypertrophy: a meta-analysis and treatment algorithm. Plast. Reconstr. Surg. 2011; 127(6): 2224-31.

5. Antevski B.M., Smilevski D.A., Stojovski M.Z., Filipovski V.A., Banev S.G. Extreme gigantomastia in pregnancy: Case report and review of literature. Arch. Gynecol. Obstet. 2007; 275(2): 149-53.

6. Ezem B.U., Osuagwu C.C., Opara K.A. Gestational gigantomastia with complete resolution in a Nigerian woman. BMJ Case Rep. 2011; Feb 15. pii: bcr0120102632.

7. Rezai S., Nakagawa J.T., Tedesco J., Chadee A., Gottimukkala S., Mercado R., Henderson C.E. Gestational gigantomastia complicating pregnancy: a case report and review of the literature. Сase Rep. Obstet. Gynecol. 2015; 2015: Article ID 892369.

8. Swelstad M.R., Swelstad B.B., Rao V.K., Gutowski K.A. Management of gestational gigantomastia. Plast. Reconstr. Surg. 2006; 118(4): 840-8.

9. Rahman G.A., Adigun I.A., Yusuf I.F. Macromastia: a review of presentation and management. Niger. Postgrad. Med. J. 2010; 17(1): 45-9.

10. Малыгин Е.Н., Бутина М.Н. Проблема макромастии: клиника, диагностика, лечение. Гинекология. 1999; 1: 10-4. [Malygin E.N., Butina M.N. The problem of macromastia: clinic, diagnosis, treatment. Ginekologiya. 1999; 1: 10-4. (in Russian)]

11. Wolner-Hanssen P., Palmer B., Sjoberg N.O., Astedt B. Gigantomastia. Acta Obstet. Gynecol. Scand. 1981; 60: 525-7.

12. Cho M.J., Yang J.H., Choi H.G., Kim W.S., Yu Y.B., Park K.S. An idiopathic gigantomastia. Ann. Surg. Treat. Res. 2015; 88(3): 166-9.

13. Lanzon A.E., Navarra S.V. Gigantomastia in a patient with systemic Lupus erythematosus successfully treated by reduction mammoplasty. Lupus. 2009;18(14): 1309-12.

14. Sakai T., Fujimori M., Tominaga Y., Kanai T., Ito K., Shingu K. et al. A case of unilateral gravid macromastia in 23-year-old Japanese woman associated with elevated serum CA19-9. Breast Cancer. 2005; 12(3): 238-42.

15. Agarwal N., Kriplani A., Gupta A., Bhatla N. Management of gigantomastia complicating pregnancy. A case report. J. Reprod. Med. 2002; 47(10): 871-4.

16. Сенча А.Н., Фазылова С.А., Евсеева Е.В., Гус А.И. Ультразвуковое исследования молочных желез. М.: ГЭОТАР-Медиа; 2017. 360с. [Sencha A.N., Fazylova S.A., Evseeva E.V., Gus A.I. Ultrasound examination of mammary glands. Moscow: GEOTAR-Media; 2017. 360p. (in Russian)]

17. Воскобойников В.В., Ищенко А.Л., Фирсов А.В., Кац Л.Е., Бельцевич Д.Г. Сочетание макромастии и миастении. Клиническое наблюдение. Эндокринная хирургия. 2014; 3: 35-8. [Voskoboinikov V.V., Ishchenko A.L., Firsov A.V., Katz L.E., Beltsevich D.G. The combination of macromastia and myasthenia gravis. Clinical observation. Endokrinnaya hirurgiya. 2014; 3: 35-8. (in Russian)]

18. Пароконная А.А., Нечушкин М.И., Горобец Е.С., Козаченко В.П., Любченко Л.Н., Тютюнник В.А., Твердикова М.А. Макромастия и миастения на фоне беременности. Клиническое наблюдение. Проблемы репродукции. 2008; 6: 91-3. [Parokonnaya A.A., Nechushkin M.I., Gorobets E.S., Kozachenko V.P., Lyubchenko L.N., Tyutyunnik V.A., Tverdikova M.A. Macromastia and myasthenia gravis during pregnancy. Clinical observation. Problemyi reproduktsii. 2008; 6: 91-3. (in Russian)]

19. Dem A., Wone H., Faye M.E., Dangou J.M., Touré P. Bilateral gestational macromastia: case report. J. Gynecol. Obstet. Biol. Reprod. 2009; 38(3): 254-7.

20. Scarabin C., Koskas M., Bornes M., Azria E., Luton D. Gigantomastia and vulvar lactating adenoma in a patient with myasthenia during pregnancy. Am. J. Obstet. Gynecol. 2010; 203(4): e5-8.

21. Lewison E.F., Jones G.S., Trimble F.H., da Lima L.C. Gigantomastia complicating pregnancy. Surg. Gynecol. Obstet. 1960; 110: 215-23.

22. Rausky J., Burin des Roziers B., Daoud G., Cartier S. Gigantomastia complicating pregnancy. A case report. J. Gynecol. Obstet. Biol. Reprod. 2011; 40(4): 367-70.

23. Tarallo M., Cigna E., Fino P., Lo Torto F., Scuderi N. Macromastia surgical therapy. Ann. Ital. Chir. 2011; 82(3): 191-5.

Received 09.06.2017

Accepted 23.06.2017

About the Authors

Sencha Alexander, MD, head of the department of visual diagnostics, Medical Research Center of Obstetrics, Gynecology, and Perinatology named
after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79688449015. E-mail: senchavyatka@mail.ru
Gus Alexander Iosifovich, MD, Professor, Head of the Department of ultrasound and functional diagnostics, Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79852319744. E-mail: aleksandr_gus@mail.ru
Rodionov Valery V., MD, head of the department of breast pathology, Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79272710492. E-mail: dr.valery.rodionov@gmail.com
Shmakov Roman Georgievich, MD, Ph.D., chief physician, Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79272710492
Bikeyev Yury Vasilievich, doctor of the department of ultrasound and functional diagnostics, Medical Research Center of Obstetrics, Gynecology, and Perinatology named
after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79037130303. E-mail: yu.bikeev@gmail.com
Kometova Vlada Vladimirovna, Ph.D., Senior Researcher, Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79051837783. E-mail: vladakometova@gmail.com
Gailish Yuri Petrovich, doctor of the Department of Breast Pathology, Medical Research Center of Obstetrics, Gynecology, and Perinatology named
after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79037130303. E-mail: y_gaylish@oparina4.ru

For citations: Sencha A.N., Gus A.I., Rodionov V.V., Shmakov R.G., Bikeev Yu.V., Kometova V.V., Gailish Yu.P. Gigantomastia: clinical cases, ultrasound characteristics. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (1): 113-20. (in Russian)
https://dx.doi.org/10.18565/aig.2018.1.113-120

Similar Articles

By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.