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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2025№9
Genetic factors in the development...

Genetic factors in the development of endometrial hyperplasia

DOI
https://dx.doi.org/10.18565/aig.2025.121

Churnosov V.I., Ponomarenko I.V., Churnosov M.I.

Belgorod State National Research University, Belgorod, Russia

Endometrial hyperplasia is a gynecological disease characterized by uneven proliferation of the endometrium with an increased gland-to-stroma ratio compared to the normal endometrium. Genetic factors play a significant role in the development of endometrial hyperplasia. The article presents current data on the genetic factors that contribute to this disease. The genetic studies have demonstrated associations with the development of endometrial hyperplasia of certain groups of candidate genes: growth factor genes (TGFß-1, FGFR2, IGF1, EGF), cytokines (TNFα, Ltα, TNFR1, ТNFR2, RANTES, I-TAC, MIP1β, MCP1, SDF1, IL-8, RАNТES), cytochromes (CYP2D6, CYP19A1), lipid metabolism (APOE, FTO), menarche (UGT2B4, LIN28B, ZNF483, LHCGR, FSHB, F13A1, BSX, TMEM38B, 3q13.32, COMT, KISS1, FTO), estrogen receptors (ESR2), oncogenes (AKT1, KRAS, EGFR, PIK3CA, BRAF, NRAS, CTNNB1, PTEN, ARID1A). In addition, a number of studies have shown a link between endometrial hyperplasia and the expression of estrogen receptors, cyclooxygenase-2, and a number of oncogenic microRNAs (miR-18a, miR-210, miR-221, and miR-222). It should be noted that the influence of genetic factors on the development of endometrial hyperplasia has been studied in fragments; the number of associative studies is extremely small, and genome-wide studies of endometrial hyperplasia have not been conducted.
Conclusion: Today, there is a critical need to continue further genetic and epidemiological studies of endometrial hyperplasia.

Authors’ contributions: Churnosov V.I. – literature search and analysis, data summary, writing the text of the manuscript; Ponomarenko I.V. – developing the concept of the article, editing the text of the manuscript; Churnosov M.I. – reviewing, final editing.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was supported by the Russian Science Foundation Grant No. 25-25-00034, 
https://rscf.ru/project/25-25-00034/.
For citation: Churnosov V.I., Ponomarenko I.V., Churnosov M.I. 
Genetic factors in the development of endometrial hyperplasia. 
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (9): 40-45 (in Russian)
https://dx.doi.org/10.18565/aig.2025.121

Keywords

endometrial hyperplasia
candidate genes
genetic factors
Full text (in Russian)

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Received 06.05.2025

Accepted 20.08.2025

About the Authors

Vladimir I. Churnosov, PhD student at the Department of Biomedical Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, vchurnosov@yandex.kz, https://orcid.org/0009-0007-8519-4594
Irina V. Ponomarenko, Dr. Med. Sci., Professor at the Department of Medical and Biological Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, ponomarenko_i@bsuedu.ru, https://orcid.org/0000-0002-5652-0166
Mikhail I. Churnosov, Dr. Med. Sci., Head of the Department of Medical and Biological Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, churnosov@bsuedu.ru, https://orcid.org/0000-0003-1254-6134
Corresponding author: Irina V. Ponomarenko, ponomarenko_i@bsuedu.ru

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