About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
Reviewing
Procedure for reviewingReviewers 2023-2024
About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
Reviewing
Procedure for reviewingReviewers 2023-2024
Logout
Obstetrics and Gynegology2024№3
Risk factors for uterine fibroids

Risk factors for uterine fibroids

DOI
https://dx.doi.org/10.18565/aig.2023.275

Ponomarenko M.S., Reshetnikov E.A., Ponomarenko I.V., Churnosov M.I.

Belgorod State National Research University, Belgorod, Russia

Uterine fibroids are the most common benign tumors in women. Among other gynecological conditions, the prevalence of uterine fibroids is high, ranking second only to inflammatory diseases of the female reproductive system. This disease has a significant impact on the female reproductive health, and it also decreases the quality of life. In addition, uterine fibroids have a negative economic effect on health systems around the world; this impact is estimated at hundreds of billions of dollars annually. According to the literature, risk factors play an important role in the development of this disease.
The analysis of the literature data showed that the risk factors for uterine fibroids are numerous and may include heredity, vitamin D3 deficiency, race (African Americans), obesity, diabetes mellitus, hypertension, early menarche, absence of childbirth in the patient’s history, alcohol, eating habits, stress, low physical activity.
Conclusion: Despite the large amount of evidence on the issue of risk factors for uterine fibroids available in the literature, not all the mechanisms underlying the relationship of certain risk factors with the disease are currently clear and therefore it is necessary to carry out further research on this issue.

Authors’ contributions: Ponomarenko M.S. – search and analysis of literature, summarizing the data, writing the text of the article; Ponomarenko I.V. – editing the text of the article; Reshetnikov E.A. – development of the concept and outline of the article; Churnosov M.I. – reviewing, final editing of the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Ponomarenko M.S., Reshetnikov E.A., Ponomarenko I.V., Churnosov M.I. Risk factors for uterine fibroids. 
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (3): 20-27 (in Russian)
https://dx.doi.org/10.18565/aig.2023.275

Keywords

uterine fibroids
risk factors
Full text (in Russian)

References

  1. Yang Q., Ciebiera M., Bariani M.V., Ali M., Elkafas H., Boyer T.G. et al. Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment. Endocr. Rev. 2022; 43(4): 678-719. https://dx.doi.org/110.1210/endrev/bnab039.
  2. Coutinho L.M., Assis W.A., Spagnuolo-Souza A., Reis F.M. Uterine fibroids and pregnancy: how do they affect each other? Reprod. Sci. 2022; 29(8): 2145-51. https://dx.doi.org/10.1007/s43032-021-00656-6.
  3. Don E.E., Mijatovic V., Huirne J.A.F. Infertility in patients with uterine fibroids: a debate about the hypothetical mechanisms. Hum. Reprod. 2023; 38(11): 2045-54. https://dx.doi.org/10.1093/humrep/dead194.
  4. Stewart E.A., Nowak R.A. Uterine fibroids: hiding in plain sight. Physiology (Bethesda). 2022; 37(1): 16-27. https://dx.doi.org/10.1152/physiol.00013.2021.
  5. Lou Z., Huang Y., Li S., Luo Z., Li C., Chu K. et al. Global, regional, and national time trends in incidence, prevalence, years lived with disability for uterine fibroids, 1990-2019: an age-period-cohort analysis for the global burden of disease 2019 study. BMC Public Health. 2023; 23(1): 916. https://dx.doi.org/10.1186/s12889-023-15765-x.
  6. Pavone D., Clemenza S., Sorbi F., Fambrini M., Petraglia F. Epidemiology and risk factors of uterine fibroids. Best Pract. Res. Clin. Obstet. Gynaecol. 2018; 46: 3-11. https://dx.doi.org/110.1016/j.bpobgyn.2017.09.004.
  7. Islam M.S., Akhtar M.M., Segars J.H., Alkatout I. et al. Vitamin D deficiency and uterine fibroids: an opportunity for treatment or prevention? Fertil. Steril. 2021; 115(5): 1175-6. https://dx.doi.org/10.1016/j.fertnstert.2021.02.040.
  8. Machado-Lopez A., Simón C., Mas A. Molecular and cellular insights into the development of uterine fibroids. Int. J. Mol. Sci. 2021; 22(16): 8483. https://dx.doi.org/10.3390/ijms22168483.
  9. Qu Y., Chen L., Guo S., Liu Y., Wu H. Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study. Front. Endocrinol. (Lausanne). 2023; 14: 1133260. https://dx.doi.org/10.3389/fendo.2023.1133260.
  10. Пономаренко И.В., Чурносов М.И. Современные представления об этиопатогенезе и факторах риска лейомиомы матки. Акушерство и гинекология. 2018; 8: 27-32. [Ponomarenko I.V., Churnosov M.I. Contemporary ideas about etiopathogenesis and risk factors of uterine leiomyoma. Obstetrics and Gynecology. 2018; (8): 27-32. (in Russian)]. https://dx.doi.org/10.18565/aig.2018.8.27-32.
  11. Koltsova A.S., Efimova O.A., Pendina A.A. A view on uterine leiomyoma genesis through the prism of genetic, epigenetic and cellular heterogeneity. Int. J. Mol. Sci. 2023; 24(6): 5752. https://dx.doi.org/10.3390/ijms24065752.
  12. Пономаренко И.В., Полоников А.В., Чурносов М.И. Полиморфные локусы гена LHCGR, ассоциированные с развитием миомы матки. Акушерство и гинекология. 2018; 10: 86-91. [Ponomarenko I.V., Polonikov A.V., Churnosov M.I. Polymorphic loci of the LHCGR gene associated with the development of uterine fibroids. Obstetrics and Gynecology. 2018; (10): 86-91. (in Russian)] https://dx.doi.org/10.18565/aig.2018.10.86-91.
  13. Ponomarenko I., Reshetnikov E., Polonikov A., Verzilina I., Sorokina I., Yermachenko A. et al. Candidate genes for age at menarche are associated with uterine leiomyoma. Front. Genet. 2021; 11: 512940. https://dx.doi.org/10.3389/fgene.2020.512940.
  14. Ponomarenko M.S., Reshetnikov E.A., Churnosova M.M., Reshetnikova Y.N., Churnosov V.I., Ponomarenko I.V. Comorbidity and syntropy of benign proliferative diseases of the female reproductive system: non-genetic, genetic, and epigenetic factors (review). Research Results in Biomedicine. 2023: 9(4): 544-56. https://dx.doi.org/10.18413/2658-6533-2023-9-4-0-9.
  15. Combs A., Singh B., Nylander E., Islam M.S., Nguyen H.V., Parra E. et al. systematic review of vitamin D and fibroids: pathophysiology, prevention, and treatment. Reprod. Sci. 2023; 30(4): 1049-64. https://dx.doi.org/10.1007/s43032-022-01011-z.
  16. Singh V., Barik A., Imam N. Vitamin D3 level in women with uterine fbroid: An observational Study in Eastern Indian Population. J. Obstet. Gynaecol. India. 2019; 69(2): 161-5. https://dx.doi.org/10.1007/s13224-018-1195-4.
  17. Li S., Chen B., Sheng B., Wang J., Zhu X. The associations between serum vitamin D, calcium and uterine fibroids in Chinese women: a case-controlled study. J. Int. Med. Res. 2020; 48(5): 300060520923492. https://dx.doi.org/10.1177/0300060520923492.
  18. Ciebiera M., Ali M., Prince L., Zgliczyński S., Jakiel G., Al-Hendy A. The significance of measuring vitamin D serum levels in women with uterine fibroids. Reprod. Sci. 2021; 28(8): 2098-2109. https://dx.doi.org/10.1007/s43032-020-00363-8.
  19. Lima M.S.O., da Silva B.B., de Medeiros M.L., Dos Santos A.R., do Nascimento Brazil E.D., Filho W.M.N.E. et al. Evaluation of vitamin D receptor expression in uterine leiomyoma and nonneoplastic myometrial tissue: a cross-sectional controlled study. Reprod. Biol. Endocrinol. 2021; 19(1): 67. https://dx.doi.org/10.1186/s12958-021-00752-x.
  20. Sheng B., Song Y., Liu Y., Jiang C., Zhu X. Association between vitamin D and uterine fibroids: a study protocol of an open-label, randomised controlled trial. BMJ Open. 2020; 10(11): e038709. https://dx.doi.org/10.1136/bmjopen-2020-038709.
  21. Vergara D., Catherino W.H., Trojano G., Tinelli A. Vitamin D: mechanism of action and biological effects in uterine fibroids. Nutrients. 2021; 13(2): 597. https://dx.doi.org/10.3390/nu13020597.
  22. Elkafas H., Badary O., Elmorsy E., Kamel R., Yang Q., Al-Hendy A. Endocrine-disrupting chemicals and vitamin D deficiency in the pathogenesis of uterine fibroids. J. Adv. Pharm, Res. 2021; 5(2): 260-75. https://dx.doi.org/10.21608/aprh.2021.66748.1124.
  23. Ali M., Shahin S.M., Sabri N.A., Al-Hendy A., Yang Q. Hypovitaminosis D exacerbates the DNA damage load in human uterine fibroids, which is ameliorated by vitamin D3 treatment. Acta Pharmacol. Sin. 2019; 40(7): 957-70. https://dx.doi.org/10.1038/s41401-018-0184-6.
  24. Corachán A., Ferrero H., Aguilar A., Garcia N., Monleon J., Faus A. et al. Inhibition of tumor cell proliferation in human uterine leiomyomas by vitamin D via Wnt/β-catenin pathway. Fertil. Steril. 2019; 111(2): 397-407. https://dx.doi.org/10.1016/j.fertnstert.2018.10.008.
  25. Suneja A., Faridi F., Bhatt S., Guleria K., Mehndiratta M., Sharma R. Effect of Vitamin D3 Supplementation on Symptomatic Uterine Leiomyoma in Women with Hypovitaminosis D J. Midlife Health. 2021; 12(1): 53-60. https://dx.doi.org/10.4103/jmh.JMH_90_19.
  26. Davari T.F., Feizabad E., Vasheghani Farahani M., Amuzegar H., Moradi B., Samimi Sadeh S. The effect of vitamin D deficiency on overgrowth of uterine fibroids: A Blinded Randomized Clinical Trial. Int. J. Fertil. Steril. 2021; 15(2): 95-100. https://dx.doi.org/10.22074/IJFS.2020.134567.
  27. El Sabeh M., Borahay M.A. The future of uterine fibroid management: a more preventive and personalized paradigm. Reprod. Sci. 2021; 28(11): 3285-8. https://dx.doi.org/10.1007/s43032-021-00618-y.
  28. Harmon Q.E., Patchel S.A., Denslow S., LaPorte F., Cooper T., Wise L.A. et al. Vitamin D and uterine fibroid growth, incidence, and loss: a prospective ultrasound study. Fertil. Steril. 2022; 118(6): 1127-36. https://dx.doi.org/10.1016/j.fertnstert.2022.08.851.
  29. Markowska A., Kurzawa P., Bednarek W., Gryboś A., Mardas M., Krzyżaniak M. et al. Immunohistochemical expression of vitamin D receptor in uterine fibroids. Nutrients. 2022; 14(16): 3371. https://dx.doi.org/10.3390/nu14163371.
  30. Arjeh S., Darsareh F., Asl Z.A., Azizi Kutenaei M. Effect of oral consumption of vitamin D on uterine fibroids: A randomized clinical trial. Complement. Ther. Clin. Pract. 2020; 39: 101159. https://dx.doi.org/10.1016/j.ctcp.2020.101159.
  31. Biesalski H.K. Obesity, vitamin D deficiency and old age a serious combination with respect to coronavirus disease-2019 severity and outcome. Curr. Opin. Clin. Nutr. Metab. Care. 2021; 24(1): 18-24. https://dx.doi.org/10.1097/MCO.0000000000000700.
  32. Dimakopoulos I., Magriplis E., Mitsopoulou A.V., Karageorgou D., Bakogianni I., Micha R. et al. Association of serum vitamin D status with dietary intake and sun exposure in adults. Clin. Nut. ESPEN. 2019; 34: 23-31. https://dx.doi.org/10.1016/j.clnesp.2019.09.008.
  33. Bahrami A., Sadeghnia H.R., Tabatabaeizadeh S.A., Bahrami-Taghanaki H., Behboodi N., Esmaeili H. et al. Genetic and epigenetic factors influencing vitamin D status. J. Cell. Physiol. 2018; 233(5): 4033-443. https://dx.doi.org/10.1002/jcp.26216.
  34. Saponaro F., Saba A., Zucchi R. An update on vitamin D metabolism. Int. J. Mol. Sci. 2020; 21(18): 6573. https://dx.doi.org/10.3390/ijms21186573.
  35. Xie S., Jiang M., Liu H., Xue F., Chen X., Zhu X. Association of vitamin D anabolism-related gene polymorphisms and susceptibility to uterine leiomyomas. Front. Genet. 2022; 13: 844684. https://dx.doi.org/10.3389/fgene.2022.844684.
  36. Hellwege J.N., Jeff J.M., Wise L.A., Gallagher C.S., Wellons M., Hartmann K.E. et al. Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum. Genet. 2017; 136(11-12): 1497-8. https://dx.doi.org/10.1007/s00439-017-1846-z.
  37. Morhason-Bello I.O., Adebamowo C.A. Epidemiology of uterine fibroid in black African women: a systematic scoping review. BMJ Open. 2022; 12(8): e052053. https://dx.doi.org/10.1136/bmjopen-2021-052053.
  38. Baird D.D., Patchel S.A., Saldana T.M., Umbach D.M., Cooper T., Wegienka G. et al. Uterine fibroid incidence and growth in an ultrasound-based, prospective study of young African Americans. Am. J. Obstet. Gynecol. 2020; 223(3): 402.e1-402.e18. https://dx.doi.org/10.1016/j.ajog.2020.02.016.
  39. Keaton J.M., Jasper E.A., Hellwege J.N., Jones S.H., Torstenson E.S., Edwards T.L. et al. Evidence that geographic variation in genetic ancestry associates with uterine fibroids. Hum. Genet. 2021; 140(10): 1433-40. https://dx.doi.org/10.1007/s00439-021-02322-y.
  40. Chuang T.D., Quintanilla D., Boos D., Khorram O. Differential expression of super-enhancer-associated long non-coding rnas in uterine leiomyomas. Reprod. Sci. 2022; 29(10): 2960-76 https://dx.doi.org/10.1007/s43032-022-00981-4.
  41. Venkatesh S.S., Ferreira T., Benonisdottir S., Rahmioglu N., Becker C.M., Granne I. et al. Obesity and risk of female reproductive conditions: A Mendelian randomisation study. PLoS Med. 2022; 19(2): e1003679. https://dx.doi.org/10.1371/journal.pmed.1003679.
  42. Alsudairi H.N., Alrasheed A.T., Dvornyk V. Estrogens and uterine fibroids: an integrated view. Research Results in Biomedicine. 2021; 7(2): 156-63. https://dx.doi.org/10.18413/2658-6533-2021-7-2-0-6.
  43. Qu Y., Chen L., Guo S., Liu Y., Wu H. Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study. Front. Endocrinol. (Lausanne). 2023; 14: 1133260. https://dx.doi.org/10.3389/fendo.2023.1133260.
  44. Qin H., Lin Z., Vásquez E., Luan X., Guo F., Xu L. Association between obesity and the risk of uterine fibroids: a systematic review and meta-analysis. J. Epidemiol. Community Health. 2021; 75(2): 197-204. https://dx.doi.org/10.1136/jech-2019-213364.
  45. Afrin S., Ramaiyer M., Begum U.A.M., Borahay M.A. Adipocyte and Adipokines Promote a Uterine Leiomyoma Friendly Microenvironment. Nutrients. 2023; 15(3): 715. https://dx.doi.org/10.3390/nu15030715.
  46. Afrin S., El Sabah M., Manzoor A., Miyashita-Ishiwata M., Reschke L., Borahay M.A. Adipocyte coculture induces a pro-inflammatory, fibrotic, angiogenic, and proliferative microenvironment in uterine leiomyoma cells. Biochim. Biophys. Acta Mol. Basis Dis. 2023; 1869(1): 166564. https://dx.doi.org/10.1016/j.bbadis.2022.166564.
  47. Reschke L., Afrin S., El Sabah M., Charewycz N., Miyashita-Ishiwata M., Borahay M.A. Leptin induces leiomyoma cell proliferation and extracellular matrix deposition via JAK2/STAT3 and MAPK/ERK pathways. F S Sci. 2022; 3(4): 383-391. https://dx.doi.org/10.1016/j.xfss.2022.05.001.
  48. Chen Y., Xiong N., Xiao J., Huang X., Chen R., Ye S. et al. Association of uterine fibroids with increased blood pressure: a cross-sectional study and meta-analysis. Hypertens. Res. 2022; 45(4): 715-21. https://dx.doi.org/10.1038/s41440-022-00856-w.
  49. Fischer N.M., Nieuwenhuis T.O., Singh B., Yenokyan G., Segars J.H. Angiotensin-converting enzyme inhibitors reduce uterine fibroid incidence in hypertensive women. J. Clin. Endocrinol. Metab. 2021; 106(2): e650-e659. https://dx.doi.org/10.1210/clinem/dgaa718.
  50. Ye M., Huang W., Chen F., Chen W., Zhu X. Dynamic volume variation of uterine leiomyomas during pregnancy. Int. J. Gynaecol. Obstet. 2023; 161(2): 417-22. https://dx.doi.org/10.1002/ijgo.14467.
  51. Kwas K., Nowakowska A., Fornalczyk A., Krzycka M., Nowak A., Wilczyński J. et al. Impact of contraception on uterine fibroids. Medicina (Kaunas). 2021; 57(7): 717. https://dx.doi.org/10.3390/medicina57070717.
  52. Stewart E.A., Cookson C.L., Gandolfo R.A., Schulze-Rath R. Epidemiology of uterine fibroids: a systematic review. BJOG. 2017; 124(10): 1501-12. https://dx.doi.org/10.1111/1471-0528.14640.
  53. Chiaffarino F., Cipriani S., Ricci E., La Vecchia C., Chiantera V., Bulfoni A. et al. Alcohol consumption and risk of uterine myoma: A systematic review and meta-analysis. PLoS One. 2017; 12(11): e0188355. https://dx.doi.org/10.1371/journal.pone.0188355.
  54. Takala H., Yang Q., El Razek A.M.A., Ali M., Al-Hendy A. Alcohol consumption and risk of uterine fibroids. Curr. Mol. Med. 2020; 20(4): 247-58. https://dx.doi.org/10.2174/1566524019666191014170912.
  55. Kim S., Han K., Choi S.Y., Yang S.Y., Choi S.H., Yim J.Y. et al. Alcohol consumption and the risk of new-onset uterine leiomyomas: a nationwide population-based study in 2.5 million Korean women aged 20 to 39 years. Am. J. Obstet. Gynecol. 2023; 229(1): 45.e1-45.e18. https://dx.doi.org/10.1016/j.ajog.2023.03.041.
  56. Wise L.A., Laughlin-Tommaso S.K. Epidemiology of uterine fibroids: from menarche to menopause. Clin. Obstet. Gynecol. 2016; 59(1): 2-24. https://dx.doi.org/10.1097/GRF.0000000000000164.
  57. Wesselink A.K., Wegienka G., Coleman C.M., Geller R.J., Harmon Q.E., Upson K. et al. A prospective ultrasound study of cigarette smoking and uterine leiomyomata incidence and growth. Am. J. Obstet. Gynecol. 2023; 229(2): 151.e1-151.e8. https://dx.doi.org/10.1016/j.ajog.2023.04.041.
  58. Whitcomb B.W., Purdue-Smithe A.C., Szegda K.L., Boutot M.E., Hankinson S.E., Manson J.E. et al. Cigarette smoking and risk of early natural menopause. Am. J. Epidemiol. 2018; 187(4): 696-704. https://dx.doi.org/10.1093/aje/kwx292.
  59. Szydłowska I., Nawrocka-Rutkowska J., Brodowska A., Marciniak A., Starczewski A., Szczuko M. Dietary natural compounds and vitamins as potential cofactors in uterine fibroids growth and development. Nutrients. 2022; 14(4): 734. https://dx.doi.org/10.3390/nu14040734.
  60. Davis C.P., Garzia N.A., Cushing-Haugen K., Terry K.L., Chiu Y.H., Sandoval-Insausti H. et al. Fruit and vegetable consumption, pesticide residue intake from consumption of fruits and vegetables, and risk of uterine fibroids. F S Sci. 2023; 4(1): 90-9. https://dx.doi.org/10.1016/j.xfss.2022.12.001.
  61. Ciebiera M., Szymańska-Majchrzak J., Sentkowska A., Kilian K., Rogulski Z., Nowicka G. et al. Alpha-tocopherol serum levels are increased in caucasian women with uterine fibroids: A Pilot Study. Biomed. Res. Int. 2018; 2018: 6793726. https://dx.doi.org/10.1155/2018/6793726.
  62. Orta O.R., Terry K.L., Missmer S.A, Harris H.R. Dairy and related nutrient intake and risk of uterine leiomyoma: a prospective cohort study. Hum. Reprod. 2020; 35(2): 453-63. https://dx.doi.org/10.1093/humrep/dez278.
  63. Tinelli A., Vinciguerra M., Malvasi A., Andjić M., Babović I., Sparić R. Uterine fibroids and diet. Int. J. Environ. Res. Public Health. 2021; 18(3): 1066. https://dx.doi.org/10.3390/ijerph18031066.
  64. Qin H., Lin Z., Vásquez E., Luan X., Guo F., Xu L. High soy isoflavone or soy-based food intake during infancy and in adulthood is associated with an increased risk of uterine fibroids in premenopausal women: a meta-analysis. Nutr. Res. 2019; 71: 30-42. https://dx.doi.org/10.1016/j.nutres.2019.06.002.
  65. Vandenplas Y., Hegar B., Munasir Z., Astawan M., Juffrie M., Bardosono S. et al. The role of soy plant-based formula supplemented with dietary fiber to support children's growth and development: An expert opinion. Nutrition. 2021; 90: 111278. https://dx.doi.org/10.1016/j.nut.2021.111278.
  66. Langton C.R., Harmon Q.E., Upson K., Baird D.D. Soy-based infant formula feeding and uterine fibroid development in a Prospective Ultrasound Study of Black/African-American Women. Environ. Health Perspect. 2023; 131(1): 17006. https://dx.doi.org/10.1289/EHP11089.
  67. Hazimeh D., Massoud G., Parish M., Singh B., Segars J., Islam M.S. Green tea and benign gynecologic disorders: a new trick for an old beverage? Nutrients. 2023; 15(6): 1439. https://dx.doi.org/10.3390/nu15061439.
  68. Qin H., Lin Z., Vásquez E., Xu L. The association between chronic psychological stress and uterine fibroids risk: A meta-analysis of observational studies. Stress Health. 2019; 35(5): 585-94. https://dx.doi.org/10.1002/smi.2895.

Received 27.11.2023

Accepted 19.02.2024

About the Authors

Marina S. Ponomarenko, graduate student of the Department of Biomedical Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod,
Pobedy str., 85, +7(4722)30-13-83, ponomarenkomc@yandex.ru, https://orcid.org/0009-0009-0312-0829
Evgeny A. Reshetnikov, Dr. Sci. (Bio), Professor of the Department of Medical and Biological Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, reshetnikov@bsu.edu.ru, http://orcid.org/0000-0002-5429-6666
Irina V. Ponomarenko, Dr. Sci. (Med), Professor of the Department of Medical and Biological Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, ponomarenko_i@bsu.edu.ru, https://orcid.org/0000-0002-5652-0166
Mikhail I. Churnosov, Dr. Sci. (Med), Head of the Department of Medical and Biological Disciplines, Belgorod State National Research University, 308015, Russia, Belgorod, Pobedy str., 85, +7(4722)30-13-83, churnosov@bsu.edu.ru, http://orcid.org/0000-0003- 1254-6134
Corresponding author: Irina V. Ponomarenko, ponomarenko_i@bsu.edu.ru

Similar Articles

№9 / 2022
Kapustin R.V., Kopteeva E.V., Alekseenkova E.N., Tsybuk E.M., Arzhanova O.N., Kogan I.Yu.
Risk factors for shoulder dystocia during labor in women with diabetes mellitus
№10 / 2024
Artymuk N.V., Marochko T.Yu., Artymuk D.A., Apresyan S.V., Kolesnikova N.B., Atalyan A.V., Shibelgut N.M., Batina N.A.
Risk factors and protective factors for refractory postpartum hemorrhage
№8 / 2022
Baev O.R., Prikhodko A.M., Ziganshina M.M., Evgrafova A.V., Khomyakova E.V.
Antenatal and intrapartum risk factors associated with fetal hypoxia in labor
№1 / 2024
Tskhay V.B., Pashov A.I., Rachkovskaya V.V.
The problem of differential diagnosis of leiomyosarcoma in patients planning surgical treatment for uterine fibroids
№2 / 2024
Krot I.F., Rukhlyada N.N., Romanova L.A., Reznik V.A., Sergienko O.I., Chikhladze B.U., Vartanyan R.A.
Myomectomy during cesarean section
By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.