Etiopathogenetic mechanisms of uterine fibroids development

Ponomarenko M.S., Reshetnikov E.A., Ponomarenko I.V., Churnosov M.I.

Belgorod State National Research University, Belgorod, Russia

Uterine fibroids are the most common benign tumors in women. However, despite the high incidence of uterine fibroids among reproductive-aged women, its negative impact on a woman’s quality of life, and health care costs for the treatment of patients with uterine tumors, there is currently no unified understanding of the etiopathogenesis of this disease. The modern data on the causes and mechanisms of uterine fibroids development are considered in the article. Uterine fibroids have a complex, multifactorial nature. Genetic, epigenetic factors, dysregulation of key signaling pathways involved in cell proliferation, apoptosis, extracellular matrix proliferation, as well as reactions to steroid hormones play an important role in the development and growth of myoma nodes.
Conclusion: Modern views on the etiopathogenesis of uterine fibroids indicate that this disease has a complex, multifactorial nature. The development of this disease involves genetic and epigenetic mechanisms, reactions to steroid hormones, dysregulation of key signaling pathways, etc. However, in spite of significant progress in understanding of uterine fibroids pathophysiology, today there are still more questions than answers.

Authors’ contributions: Ponomarenko M.S. – search and analysis of literature, summarizing the data, writing the text of the article; Ponomarenko I.V. – editing the text of the article; Reshetnikov E.A. – development of the concept and outline of the article; Churnosov M.I. – reviewing, final editing of the article.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Ponomarenko M.S., Reshetnikov E.A., Ponomarenko I.V., Churnosov M.I. Etiopathogenetic mechanisms of uterine fibroids development.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2024; (1): 34-41 (in Russian)


uterine fibroids


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Received 18.10.2023

Accepted 14.12.2023

About the Authors

Marina S. Ponomarenko, graduate student of the Department of Biomedical Disciplines, Belgorod State National Research University, +7(4722)30-13-83,,, 308015, Russia, Belgorod, Pobedy str., 85.
Evgeny A. Reshetnikov, Dr. Bio. Sci., Professor of the Department of Medical and Biological Disciplines, Belgorod State National Research University, +7(4722)30-13-83,,, 308015, Russia, Belgorod, Pobedy str., 85.
Irina V. Ponomarenko, Dr. Med. Sci., Professor of the Department of Medical and Biological Disciplines, Belgorod State National Research University, +7(4722)30-13-83,,, 308015, Russia, Belgorod, Pobedy str., 85.
Mikhail I. Churnosov, Dr. Med. Sci., Head of the Department of Medical and Biological Disciplines, Belgorod State National Research University, +7(4722)30-13-83,,, 308015, Russia, Belgorod, Pobedy str., 85.
Corresponding author: Irina V. Ponomarenko,

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