Дифференцированный подход к выбору терапии у женщин с аномальными маточными кровотечениями
Objective. To review published scientific papers in order to analyze an evidence base for a strategy for choosing therapy in women with abnormal uterine bleeding (AMC), obesity, and smoking.Соловьева А.В., Ермоленко К.С.
Material and methods. Foreign and Russian articles published in the past 7 years and selected in Pubmed were used.
Results. The types of AMC were analyzed in relation to its etiological factors. Different methods for treating patients with uterine bleeding varying in severity were comparatively analyzed.
Conclusion. It is appropriate to concomitantly use dydrogesterone and tranexamic acid in phase 2 of the menstrual cycle during 3-4 menstrual cycles in women who smoke and/or in those with obesity and AMC.
Keywords
abnormal uterine bleeding
smoking
obesity
dydrogesterone
tranexamic acid
Supplementary Materials
References
1. Munro M.G., Critchley H.O., Fraser I.S. The FIGO classification of causes of abnormal uterine bleeding in the reproductive years. Fertil. Steril. 2011; 95(7): 2204-8.
2. Duckitt K., Collins S. Menorrhagia. BMJ Clin Evid. 2012; 2012: pii: 0805. Available at: www. ncbi. nlm. nih.gov
3. Радзинский В.Е., ред. Неразвивающаяся беременность. 2-е изд. М.: ГЭОТАР-Медиа; 2016. 176с. [Radzinsky V.E., ed. Non-developing pregnancy. 2nd ed. Moscow: GEOTAR-Media; 2016. 176p. (in Russian)]
4. Соловьева А.В., Оленев А.С., Гаче В., Хорольский В.А., Кузнецова О.А. Анемии у женщин репродуктивного возраста. Вопросы гинекологии, акушерства и перинатологии. 2016; 15(4): 59-63. [Solovyeva A.V., Olenev A.S., Gache V., Khorolsky V.A., Kuznetsova O.A. Anemia in women of reproductive age. Voprosy ginekologii, akusherstva i perinatologii. 2016; 15(4): 59-63. (in Russian)]
5. Singh S., Best C., Dunn S., Leyland N., Wolfman W.L.; CLINICAL PRACTICE – GYNAECOLOGY COMMITTEE. Abnormal uterine bleeding in pre-menopausal women. J. Obstet. Gynaecol. Can. 2013; 35(5):473-5.
6. Farquhar C., Brown J. Oral contraceptive pill for heavy menstrual bleeding. Cochrane Database Syst. Rev. 2009; (4): CD000154.
7. Heavy menstrual bleeding: assessment and management. Clinical guideline (CG44). Published date: January 2007. Last updated: August 2016. Available at: https://www.nice.org.uk/guidance/cg44
8. Trivedi N., Chauhan N., Vaidya V. Effectiveness and safety of dydrogesterone in regularization of menstrual cycle: a post-marketing study. Gynecol. Endocrinol. 2016; 32(8): 667-71.
9. Васюкова О. В., Конь И.А., Ларионова З. Г., Леонтьева И.В., Павловская Е.В., Порядина Г.И., Розанов В.Б., Стародубова А.В., Щербакова М.Ю. Рекомендации по диагностике, лечению и профилактике ожирения у детей и подростков. Александров А.А., Петеркова В.А., ред. М.: Практика; 2015. [Vasyukova O.V., Kon I.A., Larionova Z.G., Leontieva I.V., Pavlovskaya E.V., Poryadina G.I., Rozanov V.B., Starodubova A.V., Scherbakova M.Yu. Recommendations for the diagnosis, treatment and prevention of obesity in children and adolescents. Alexandrov A.A., Peterkova V.A., ed. Moscow: Praktika; 2015. (in Russian)]
10. Кузнецова И.В., Успенская Ю.Б., Ведзижева Э.Р., Васильева И.В. Ожирение и женская фертильность. Акушерство и гинекология: новости, мнения, обучение. 2015; 3: 109-17. [Kuznetsova I.V., Uspenskaya Yu.B., Vedzizheva E.R., Vasilieva I.V. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie.. 2015; 3: 109-17. (in Russian)]
11. Думановская М.Р., Чернуха Г.Е., Асатурова А.В., Коган Е.А. Частота выявления и структура гиперплазии эндометрия в различные возрастные периоды. Акушерство и гинекология. 2015; 3: 40-4. [Dumanovskaya M.R., Chernukha G.E., Asaturova A.V., Kogan E.A. The detection rate and pattern of endometrial hyperplasia in different age periods. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2015; (3): 40-4. (in Russian)]
12. Санта-Мария Фернандес Д.О., Кузнецова И.В., Гитель Е.П. Комплексная терапия нарушений менструального цикла у пациенток раннего репродуктивного возраста с избыточной массой тела и ожирением. Эффективная фармакотерапия. 2015; 5: 26-32. [Santa Maria Fernández D.O., Kuznetsova I.V., Gitel E.P. Complex therapy of menstrual cycle disorders in patients of early reproductive age with excessive body weight and obesity. Effektivnaya farmakoterapiya. 2015; 5: 26-32. (in Russian)]
13. Pomp E.R., le Cessie S., Rosendaal F.R., Doggen C.J. Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations. Br. J. Haematol. 2007; 139(2): 289-96.
14. Trussell J., Jordan B. Reproductive health risks in persperctive. Contraception. 2006; 73(5): 437-9.
15. Shindler A.E. Progestational effects of dydrogesterone in vitro, in vivo and on the human endometrium. Maturitas. 2009; 65(Suppl. 1): S3-11.
16. Carlson M.J., Thiel K.W., Yang S., Leslie KK. Catch it before it kills: progesterone, obesity, and the prevention of endometrial cancer. Discov. Med. 2012; 14(76): 215-22.
17. Heavy menstrual bleeding: Then and now. Gynaecol. Perinatol. 2018; 1.2:130-9.
Received 08.12.2017
Accepted 22.12.2017
About the Authors
Solovyeva Alina Viktorovna, MD Professor of the Department of Obstetrics Gynecology with a course of perinatology, Peoples’ Friendship University of Russia,Ministry of Education and Science of Russia. 117198, Russia, Moscow, Miklukho-Maklaya str. 8. Tel.: +79854477928
Ermolenko Kristina Stanislavovna, Candidate of Medical Science, Assistant of the Department of Obstetrics of Gynecology and Perinatology,
Peoples’ Friendship University of Russia, Ministry of Education and Science of Russia. 117198, Russia, Moscow, Miklukho-Maklaya str. 8. Tel.: +79197664984
For citations: Solovyeva A.V., Ermolenko K.S. Differentiated approach
to choosing therapy for women with abnormal uterine bleeding.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (3): 157-60. (in Russian)
https://dx.doi.org/10.18565/aig.2018.3.157-160
Similar Articles
