Indocyanine green (ICG) for the detection of sentinel lymph nodes in patients with endometrial cancer
Aim. To investigate the effectiveness of the ICG fluorescence technique in the detection of sentinel lymph nodes (SLN) in patients with endometrial cancer (EC).Ibragimov Z.N., Mikaya N.A.,.Trifanov Yu.N, Gorodnova T.V., Kotiv Kh.B., Yakovleva M.G., Lavrinovich O.E., Bondarev N.E., Sidoruk A.A., Smirnova O.A., Guseinov K.D., Bakhidze E.V., Meshkova I.E., Bakaeva E.Kh., Shikhzadaeva M.G., Ul’rikh E.A., Urmancheeva A.F., Berlev I.V., Belyaev A.M.
Materials and methods. The study comprised 100 patients with morphologically and clinically verified stage T1a-1bNxM0 EC, who were managed at the Petrov National Medical Research Center of Oncology of Minzdrav of Russia from September 2015 to September 2017.
Results. The use of ICG resulted in the detection of 220 SLNs in the whole study cohort (n = 100). Ninety (90%) patients were found to have bilateral SLNs. In 9/100 (9%), staining was detected only on one side. Only in one case, no SLNs were identified. The sensitivity, specificity, and accuracy of the method were 100%, 93%, and 93%, respectively. Numerous studies confirm the fact that in patients with EC, intraoperative detection, biopsy and morphological examination of SLNs contribute to a better assessment of regional lymphatic collectors, more accurate staging of the disease, and a patient-tailored surgery, which in turn can increase the overall survival of patients with EC.
Conclusion. The use of the ICG fluorescence technique for the detection of SLNs in patients with EC allows effective and safe staging of the disease.
Keywords
corpus uteri cancer
sentinel lymph node
ICG
fluorescence
References
- Берлев И.В., Ульрих Е.А., Ибрагимов З.Н., и др. Возможности детекции сигнальных лимфатических узлов при раке эндометрия радиоизотопным и флуоресцентным (ICG) методами. Вопросы онкологии. 2017; 2: 304–8. [Berlev I.V., Ulrikh E.A., Ibragimov Z.N. Possibilities of detection of sentinel lymph nodes in endometrial cancer by radioisotope and fluorescent (ICG) methods. Voprosy onkologii.2017; 2: 304–8. (In Russ.)]. eLIBRARY ID: 29114517
- Shepherd E.S., Lowe D.A. Targeted selective trachelo-colpectomy for preservation of fertility in a young woman with vaginal clear cell carcinoma. J Obstet Gynaecol. 2010; 30(4): 420–1. doi: 10.3109/01443611003681428.
- Vidal F., et al. Evaluation of the sentinel lymph node algorithm with blue dye labeling for early- stage endometrial cancer in a multicentric setting. Int. J. Gynecol. Cancer. 2013: 23: 1237–43. doi: 10.1097/IGC.0b013e31829b1b98
- Morton D.L., et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch. Surg. 1992; 127: 392–9. doi: 10.1001/archsurg.1992.01420040034005
- Kadkhodayan S., et al. Lymphatic mapping and sentinel node biopsy in endometrial cancer a feasibility study using cervical injection of radiotracer and blue dye. Nucl Med Rev Cent East Eur. 2014; 17: 55–8. doi: 10.5603/NMR.2014.0017
- Krag D.N., et al. Technical outcomes of sentinel lymph-node resection and conventional axillary- lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial. Lancet Oncol. 2007; 8: 881–8. doi: 10.1016/S1470-2045(07)70278-4
- Zavagno G., et al. A randomized clinical trial on sentinel lymph node biopsy versus axillary lymph node dissection in breast cancer: results of the Sentinella. GIVOM trial. Ann. Surg. 2008; 247: 207–10. doi: 10.1097/SLA.0b013e31812e6a73
- Kim C.H., Soslow R.A., Park K.J. Pathologic ultrastaging improves micrometastasis detection in sentinel lymph nodes during endometrial cancer staging. Gynecol Cancer. 2013; 23(5): 964–70. doi: 10.1097/IGC.0000000000000159
- Bosquet G.J., et al. Cytokeratin staining of resected lymph nodes may improve the sensitivity of surgical staging for endometrial cancer. Gynecol. Oncol. 2003; 91: 518–25. doi: 10.1016/j.ygyno.2003.08.026
Received 20.12.2019
Accepted 26.12.2019
About the Authors
Zaur N. Ibragimov, Oncologist, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Pesochny-2, St.-Petersburg,197758, Russia. Tel.: (007)-(812)-596-84-21, Fax: (007)-(812)-596-89-47. E-mail: oncl@rion.spb.ru; SPIN-код: 1566-1789, AuthorID: 919303.
Nikolay A. Mikaya, Oncologist, PhD, Head of department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47, E-mail: nmikaya@mail.ru; AuthorID: 383329. Pesochny-2, St.-Petersburg, 197758, Russia.
Yuri N. Trifanov, Oncologist, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Pesochny-2, St.-Petersburg,
197758, Russia. Tel.: (007)-(812)-596-84-21, Fax: (007)-(812)-596-89-47. E-mail: oncl@rion.spb.ru
Tatiana V. Gorodnova, Oncologist, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47. E-mail: t.gorodnova@mail.ru; SPIN-код автора в РИНЦ: 2661-9106; ORCID: 0000-0003-1719-7498. Pesochny-2, St.-Petersburg, 197758, Russia.
Khristina B. Kotiv, Oncologist, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47. E-mail: oncl@rion.spb.ru. Pesochny-2, St.-Petersburg, 197758, Russia.
Maria G. Yakovleva, Resident at the Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Pesochny-2, St.-Petersburg,
197758, Russia. Tel.: (007)-(812)-596-84-21, Fax: (007)-(812)-596-89-47. E-mail: mersend@mail.ru; ORCID: 0000-0002-1593-6771
Olga E. Lavrinovich, Oncologist, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47, E-mail: olgalav1973@mail.ru; SPIN-код: 7239-5933, AuthorID: 854658. Pesochny-2, St.-Petersburg, 197758, Russia.
Nikolay E. Bondarev, ncologist, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47. E-mail: oncl@rion.spb.ru; SPIN-код: 4788-1510, AuthorID: 277962. Pesochny-2, St.-Petersburg, 197758, Russia.
Anna A. Sidoruk, Oncologist, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47. E-mail: sidoruk_ann@mail.ru; SPIN-код: 5191-8792, AuthorID: 203398. Pesochny-2, St.-Petersburg, 197758, Russia.
Olga A. Smirnova, Oncologist, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47.E-mail: ssmirnova.oa@gmail.com; SPIN-код: 9309-7703; AuthorID: 1019011. Pesochny-2, St.-Petersburg, 197758, Russia.
Konstantin Dz. Guseynov, Oncologist, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47. E-mail: oncl@rion.spb.ru. Pesochny-2, St.-Petersburg, 197758, Russia.
Elena V. Bakhidze, Oncologist, MD, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47. E-mail: oncl@rion.spb.ru; SPIN-код: 5191-8792, AuthorID: 203398. Pesochny-2, St.-Petersburg, 197758, Russia.
Iryna E. Meshkova, Oncologist, PhD, Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21, Fax: (007)-(812)-596-89-47.E-mail: meshkova.62@bk.ru. Pesochny-2, St.-Petersburg, 197758, Russia.
Elvina K. Bakaeva, Resident at the Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47. E-mail: oncl@rion.spb.ru. Pesochny-2, St.-Petersburg, 197758, Russia.
Marianna G. Shikhzadaeva, Resident at the Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21,
Fax: (007)-(812)-596-89-47. E-mail: oncl@rion.spb.ru. Pesochny-2, St.-Petersburg, 197758, Russia.
Elena A. Ulrikh, M.D., Ph.D., Leading Researcher at the Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology;
Tel.: (007)-(812)-596-84-21, Fax: (007)-(812)-596-89-47, Professor at the Department of Oncology of North-Western State Medical University na I.I. Mechnikov,
St.-Petersburg. E-mail: elenaulrikh@yandex.ru; SPIN-код: 1110-1844, AuthorID: 668989. Pesochny-2, St.-Petersburg, 197758, Russia.
Adel F. Urmancheeva, M.D., Ph.D., Professor, Leading Researcher at the Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology;
Tel.: (007)-(812)-596-84-21, Fax: (007)-(812)-596-89-47, Professor at the Department of Oncology of North-Western State Medical University na I.I. Mechnikov,
St.-Petersburg E-mail: adaurm@mail.ru; SPIN-код: 4169-6011, AuthorID: 668976. Pesochny-2, St.-Petersburg, 197758, Russia.
Igor V. Berlev, M.D., Ph.D., Professor, Нead of Department of Gynecological Oncology in the N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21, Fax: (007)-(812)-596-89-47, Нead of Department of Gynecology of North-Western State Medical University na I.I. Mechnikov, St.-Petersburg. E-mail: iberlev@gmail.com; AuthorID: 274121; ORCID: 0000-0001-6937-2740. Pesochny-2, St.-Petersburg, 197758, Russia.
Alexey M. Belyaev Professor, M.D., Ph.D., Нead of N.N.Petrov Research Institute of Oncology; Tel.: (007)-(812)-596-84-21, Fax: (007)-(812)-596-89-47, Нead of Department of Oncology of North-Western State Medical University na I.I. Mechnikov, St.-Petersburg. E-mail: oncl@rion.spb.ru; SPIN-код: 9445-9473, AuthorID: 273109
Pesochny-2, St.-Petersburg, 197758, Russia.
For citation: Ibragimov Z.N., Mikaya N.A., Trifanov Yu.N., Gorodnova T.V., Kotiv Kh.B., Yakovleva M.G., Lavrinovich O.E., Bondarev N.E., Sidoruk A.A., Smirnova O.A., Guseinov K.D., Bakhidze E.V., Meshkova I.E., Bakaeva E.Kh., Shikhzadaeva M.G., Ul’rikh E.A., Urmancheeva A.F., Berlev I.V., Belyaev A.M. Indocyanine green (icg) for the detection of sentinel lymph nodes in patients with endometrial cancer.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 1(Suppl): 105-11 (in Russian)
https://dx.doi.org/10.18565/aig.2020.1suppl.105-111
Similar Articles
