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Obstetrics and Gynegology2021№3
Vitamin D deficiency and women’s...

Vitamin D deficiency and women’s reproductive health

DOI
https://dx.doi.org/10.18565/aig.2021.3.189-195

Artymuk N.V., Tachkova O.A.

Kemerovo State Medical University, Ministry of Health of Russia, Kemerovo, Russia
Vitamin D deficiency is recorded in various populations in 80–83% of people, more often in women than in men. There is a significant influence of vitamin D deficiency on the risk of gynecological diseases, reproductive disorders, pregnancy complications and negative outcomes. Vitamin D deficiency has been proved to be associated with spermatogenesis disorders, hypogonadism, and fertility disorders in men. Women have shown the relationship between low levels of vitamin D in the blood serum and irregular menstruation, reduced ovarian reserve, and incidence of such diseases as endometriosis, fibroids, polycystic ovary syndrome, breast cancer. D-status significantly affects female fertility and live birth rates in assisted reproduction. Hypovitaminosis D in pregnant women is associated with a high incidence of miscarriages, preeclampsia, gestational diabetes, bacterial vaginosis, as well as disorders of fetal growth and neurodevelopmental disorders in the newborn. The experimental model showed the anti-inflammatory, antiproliferative, antifibrotic and pro-apoptotic effects of vitamin D.
Conclusion. The review of the modern literature suggests that it is necessary to maintain the optimal level of vitamin D3 in the blood serum in women at all stages of life. Further studies are needed to assess the effects of vitamin D supplements during pregnancy, especially in terms of the risk of maternal adverse events.

Keywords

vitamin D deficiency
vitamin D insufficiency
D-status
fertility
reproductive health
Full text (in Russian)

References

  1. Cashman K.D. Vitamin D requirements for the future-lessons learned and charting a path forward. Nutrients. 2018; 10(5): 533. https://dx.doi.org/10.3390/nu10050533.
  2. Cashman K.D., Ritz C., Kiely M. Odin collaborators. Improved dietary guidelines for vitamin D: Application of individual participant data (IPD)-level meta-regression analyses. Nutrients. 2017; 9(5): 469. https://dx.doi.org/10.3390/nu9050469.
  3. Pilz S., Zittermann A., Obeid R., Hahn A., Pludowski P., Trummer C. et al. The role of vitamin D in fertility and during pregnancy and lactation: a review of clinical data. Int. J. Environ. Res. Public Health. 2018; 15(10): 2241. https://dx.doi.org/10.3390/ijerph15102241.
  4. Souberbielle J.C. Epidemiology of vitamin-D deficiency. Geriatr. Psychol. Neuropsychiatr. Vieil. 2016; 14(1): 7-15. https://dx.doi.org/10.1684/pnv.2016.0589.
  5. Jiang W., Wu D.B., Xiao G.B., Ding B., Chen E.Q. An epidemiology survey of vitamin D deficiency and its influencing factors. Med. Clin. (Barcelona). 2020; 154(1): 7-12. https://dx.doi.org/10.1016/j.medcli.2019.03.019.
  6. Бочкарникова А.Г., Тришкин А.Г., Пустотина О.А., Мозес В.Г. «D-статус» пациенток с репродуктивными нарушениями. Фундаментальная и клиническая медицина. 2018; 3(3): 6-11. [Bochkarnikova A.G., Trishkin A.G., Pustotina O.A., Mozes V.G. "D-status" of patients with reproductive disorders. Fundamental and clinical medicine. 2018; 3(3): 6-11. (in Russian)].
  7. Heyden E.L., Wimalawansa S.J. Vitamin D: Effects on human reproduction, pregnancy, and fetal well-being. J. Steroid Biochem. Mol. Biol. 2018; 180: 41-50. https://dx.doi.org/10.1016/j.jsbmb.2017.12.011.
  8. Agarwal S., Kovilam O., Agrawal D.K. Vitamin D and its impact on maternal-fetal outcomes in pregnancy: A critical review. Crit. Rev. Food Sci. Nutr. 2018; 58(5): 755-69. https://dx.doi.org/10.1080/10408398.2016.1220915.
  9. Arslan S., Akdevelioğlu Y. The relationship between female reproductive functions and vitamin D. J. Am. Coll. Nutr. 2018; 37(6): 546-51. https://dx.doi.org/10.1080/07315724.2018.1431160.
  10. Nandi A., Sinha N., Ong E., Sonmez H., Poretsky L. Is there a role for vitamin D in human reproduction? Horm. Mol. Biol. Clin. Investig. 2016; 25(1): 15-28. https://dx.doi.org/10.1515/hmbci-2015-0051.
  11. Cyprian F., Lefkou E., Varoudi K., Girardi G. Immunomodulatory effects of vitamin D in pregnancy and beyond. Front. Immunol. 2019; 10: 2739. https://dx.doi.org/10.3389/fimmu.2019.02739.
  12. Jukic A.M., Steiner A.Z., Baird D.D. Lower plasma 25-hydroxyvitamin D is associated with irregular menstrual cycles in a cross-sectional study. Reprod. Biol. Endocrinol. 2015; 13: 20. https://dx.doi.org/10.1186/s12958-015-0012-5.
  13. Jukic A.M., Steiner A.Z., Baird D.D. Association between serum 25-hydroxyvitamin D and ovarian reserve in premenopausal women. Menopause. 2015; 22(3): 312-6. https://dx.doi.org/10.1097/GME.0000000000000312.
  14. Kalaitzopoulos D.R., Lempesis I.G., Athanasaki F., Schizas D., Samartzis E.P., Kolibianakis E.M., Goulis D.G. Association between vitamin D and endometriosis: a systematic review. Hormones (Athens). 2020; 19(2): 109-21. https://dx.doi.org/10.1007/s42000-019-00166-w.
  15. Giampaolino P., Della Corte L., Foreste V., Bifulco G. Is there a relationship between vitamin D and endometriosis? An overview of the literature. Curr. Pharm. Des. 2019; 25(22): 2421-7. https://dx.doi.org/10.2174/1381612825666190722095401.
  16. Delbandi A.A., Torab M., Abdollahi E., Khodaverdi S., Rokhgireh S., Moradi Z. et al. Vitamin D deficiency as a risk factor for endometriosis in Iranian women. J. Reprod. Immunol. 2021; 143: 103266. https://dx.doi.org/10.1016/j.jri.2020.103266.
  17. Mehdizadehkashi A., Rokhgireh S., Tahermanesh K., Eslahi N., Minaeian S., Samimi M. The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis. Gynecol. Endocrinol. 2021 Jan 29: 1-6. https://dx.doi.org/10.1080/09513590.2021.1878138.
  18. Qiu Y., Yuan S., Wang H. Vitamin D status in endometriosis: a systematic review and meta-analysis. Arch. Gynecol. Obstet. 2020; 302(1): 141-52. https://dx.doi.org/10.1007/s00404-020-05576-5.
  19. Nodler J.L., DiVasta A.D., Vitonis A.F., Karevicius S., Malsch M., Sarda V. et al. Supplementation with vitamin D or ω-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): a double-blind, randomized, placebo-controlled trial. Am. J. Clin. Nutr. 2020; 112(1): 229-36. https://dx.doi.org/10.1093/ajcn/nqaa096.
  20. Baek J.C., Jo J.Y., Lee S.M., Cho I.A., Shin J.K., Lee S.A. et al. Vitamin D and endometriosis: Is there a correlation with disease severity? Clin. Exp. Reprod. Med. 2020; 47(3): 235-6. https://dx.doi.org/10.5653/cerm.2019.03342.r1.
  21. Mohammadi R., Tabrizi R., Hessami K., Ashari H., Nowrouzi-Sohrabi P., Hosseini-Bensenjan M., Asadi N. Correlation of low serum vitamin-D with uterine leiomyoma: a systematic review and meta-analysis. Reprod. Biol. Endocrinol. 2020; 18(1): 85. https://dx.doi.org/10.1186/s12958-020-00644-6.
  22. Judson I., Messiou C. Vitamin D deficiency in the pathogenesis of leiomyoma and intravascular leiomyomatosis: A case report and review of the literature. Gynecol. Oncol. Rep. 2020; 35: 100681. https://dx.doi.org/10.1016/j.gore.2020.100681.
  23. Mitro S.D., Zota A.R. Vitamin D and uterine leiomyoma among a sample of US women: Findings from NHANES, 2001–2006. Reprod. Toxicol. 2015; 57: 81-6. https://dx.doi.org/10.1016/j.reprotox.2015.05.013.
  24. Ciebiera M., Włodarczyk M., Ciebiera M., Zaręba K., Łukaszuk K., Jakiel G. Vitamin D and uterine fibroids-review of the literature and novel concepts. Int. J. Mol. Sci. 2018; 19(7): 2051. https://dx.doi.org/10.3390/ijms19072051.
  25. Othman E.R., Ahmed E., Sayed A.A., Hussein M., Abdelaal I.I., Fetih A.N. et al. Human uterine leiomyoma contains low levels of 1, 25 dihdroxyvitamin D3, and shows dysregulated expression of vitamin D metabolizing enzymes. Eur. J. Obstet. Gynecol. Reprod. Biol. 2018; 229: 117-22. https://dx.doi.org/10.1016/j.ejogrb.2018.08.018.
  26. Corachán A., Ferrero H., Escrig J., Monleon J., Faus A., Cervelló I., Pellicer A. Long-term vitamin D treatment decreases human uterine leiomyoma size in a xenograft animal model. Fertil. Steril. 2020; 113(1): 205-16. e4. https://dx.doi.org/10.1016/j.fertnstert.2019.09.018.
  27. Ghanavatinejad A., Rashidi N., Mirahmadian M., Rezania S., Mosalaei M., Ghasemi J., Zarnani A.H. Vitamin D3 controls TLR4- and TLR2-mediated inflammatory responses of endometrial cells. Gynecol. Obstet. Invest. 2021 Feb 4: 1-10. https://dx.doi.org/10.1159/000513590.
  28. Gupta A., Villa A., Feldman S., Citow B., Sroussi H. Site and sex-specific differences in the effect of vitamin D on human papillomavirus infections: analyses of NHANES 2009-2014. Sex. Transm. Infect. 2021; 97(1): 75-6. https://dx.doi.org/10.1136/sextrans-2020-054466.
  29. Phuthong S., Settheetham-Ishida W., Natphopsuk S., Ishida T. Genetic polymorphisms of vitamin D receptor gene are associated with cervical cancer risk in Northeastern Thailand. Asian Pac. J. Cancer Prev. 2020; 21(10): 2935-9. https://dx.doi.org/10.31557/APJCP.2020.21.10.2935.
  30. Grant W.B. Review of recent advances in understanding the role of vitamin D in reducing cancer risk: breast, colorectal, prostate, and overall cancer. Anticancer Res. 2020; 40(1): 491-9. https://dx.doi.org/10.21873/anticanres.13977.
  31. Pejovic T., Joshi S., Campbell S., Thisted S., Xu F., Xu J. Association between vitamin D and ovarian cancer development in BRCA1 mutation carriers. Oncotarget. 2020; 11(45): 4104-14. https://dx.doi.org/10.18632/oncotarget.27803.
  32. Blasiak J., Pawlowska E., Chojnacki J., Szczepanska J., Fila M., Chojnacki C. Vitamin D in triple-negative and BRCA1-deficient breast cancer-implications for pathogenesis and therapy. Int. J. Mol. Sci. 2020; 21(10): 3670. https://dx.doi.org/10.3390/ijms21103670.
  33. Voutsadakis I.A. Vitamin D receptor (VDR) and metabolizing enzymes CYP27B1 and CYP24A1 in breast cancer. Mol. Biol. Rep. 2020; 47(12): 9821-30. https://dx.doi.org/10.1007/s11033-020-05780-1.
  34. Voutsadakis I.A. Vitamin D baseline levels at diagnosis of breast cancer: A systematic review and meta-analysis. Hematol. Oncol. Stem Cell Ther. 2020 Sep 26: S1658-3876(20)30147-3. https://dx/doi.org/10.1016/j.hemonc.2020.08.005.
  35. Kanstrup C., Teilum D., Rejnmark L., Bigaard J.V., Eiken P., Kroman N., Tjønneland A., Mejdahl M.K. 25-Hydroxyvitamin D at time of breast cancer diagnosis and breast cancer survival. Breast Cancer Res. Treat. 2020; 179(3): 699-708. https://dx.doi.org/10.1007/s10549-019-05486-4.
  36. Carlberg C., Muñoz A. An update on vitamin D signaling and cancer. Semin. Cancer Biol. 2020 May 30: S1044-579X(20)30114-0. https://dx.doi.org/10.1016/j.semcancer.2020.05.018.
  37. Menichini D., Facchinetti F. Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review. Gynecol. Endocrinol. 2020; 36(1): 1-5. https://dx.doi.org/10.1080/09513590.2019.1625881.
  38. Ostadmohammadi V., Jamilian M., Bahmani F., Asemi Z. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. J. Ovarian Res. 2019; 12(1): 5. https://dx.doi.org/10.1186/s13048-019-0480-x.
  39. Trummer C., Schwetz V., Kollmann M., Wölfler M., Münzker J., Pieber T.R. et al. Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial. Eur. J. Nutr. 2019; 58(5): 2019-28. https://dx.doi.org/10.1007/s00394-018-1760-8.
  40. Chu J., Gallos I., Tobias A., Tan B., Eapen A., Coomarasamy A. Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis. Hum. Reprod. 2018; 33(1): 65-80. https://dx.doi.org/10.1093/humrep/dex326.
  41. Chu J., Gallos I., Tobias A., Robinson L., Kirkman-Brown J., Dhillon-Smith R. et al. Vitamin D and assisted reproductive treatment outcome: a prospective cohort study. Reprod. Health. 2019; 16(1): 106. https://dx.doi.org/10.1186/s12978-019-0769-7.
  42. Paffoni A., Somigliana E., Sarais V., Ferrari S., Reschini M., Makieva S. et al. Effect of vitamin D supplementation on assisted reproduction technology (ART) outcomes and underlying biological mechanisms: protocol of a randomized clinical controlled trial. The "supplementation of vitamin D and reproductive outcome" (SUNDRO) study. BMC Pregnancy Childbirth. 2019; 19(1): 395. https://dx.doi.org/10.1186/s12884-019-2538-6.
  43. Kiely M.E., Wagner C.L., Roth D.E. Vitamin D in pregnancy: Where we are and where we should go. J. Steroid Biochem. Mol. Biol. 2020; 201: 105669. https://dx.doi.org/10.1016/j.jsbmb.2020.105669.
  44. Voltas N., Canals J., Hernández-Martínez C., Serrat N., Basora J., Arija V. Effect of vitamin D status during pregnancy on infant neurodevelopment: The ECLIPSES study. Nutrients. 2020; 12(10): 3196. https://dx.doi.org/10.3390/nu12103196.
  45. Palacios C., Kostiuk L.K., Peña-Rosas J.P. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst. Rev. 2019; (7): CD008873. https://dx.doi.org/10.1002/14651858.CD008873.pub4.
  46. Gallo S., McDermid J.M., Al-Nimr R.I., Hakeem R., Moreschi J.M., Pari-Keener M. et al. Vitamin D supplementation during pregnancy: An evidence analysis center systematic review and meta-analysis. J. Acad. Nutr. Diet. 2020; 120(5): 898-924. e4. https://dx.doi.org/10.1016/j.jand.2019.07.002.
  47. Magnus M.C., Miliku K., Bauer A., Engel S.M., Felix J.F., Jaddoe V.W.V. et al. Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study. BMJ. 2018; 361: k2167. https://dx.doi.org/10.1136/bmj.k2167.
  48. Bialy L., Fenton T., Shulhan-Kilroy J., Johnson D.W., McNeil D.A., Hartling L. Vitamin D supplementation to improve pregnancy and perinatal outcomes: an overview of 42 systematic reviews. BMJ Open. 2020; 10(1): e032626. https://dx.doi.org/10.1136/bmjopen-2019-032626.
  49. Cooper C., Harvey N.C., Bishop N.J., Kennedy S., Papageorghiou A.T., Schoenmakers I. et al.; MAVIDOS Study Group. Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial. Lancet Diabetes Endocrinol. 2016; 4(5): 393-402. https://dx/doi.org/10.1016/S2213-8587(16)00044-9.
  50. Министерство здравоохранения Российской Федерации. Клинические рекомендации. Нормальная беременность. 2019. [Ministry of Health of the Russian Federation. Clinical recommendations. Normal pregnancy. 2019. (in Russian)].
  51. Гусев Е.И., Захарова И.Н., ред. Витамин D – смена парадигмы. М.: ТорусПресс; 2015. 464 с. [Gusev E.I., Zakharova I.N., ed. Vitamin D is a paradigm shift. M.: TorusPress. 2015; 464 p. (in Russian)].

Received 04.03.2021

Accepted 05.03.2021

About the Authors

Natalya V. Artymuk, MD, PhD, Professor, Head of the G.A. Ushakova Department of Obstetrics and Gynecology, Kemerovo State Medical University, Ministry of Health
of Russia. Tel.: +7(3842)73-48-56. E-mail: artymuk@gmail.com. ORCID: 0000-0001-7014-6492. 22a Voroshilova str., Kemerovo, 650056, Russian Federation.
Olga A. Tachkova, MD, PhD, Associate Professor, Department of Hospital Therapy and Clinical Pharmacology, Kemerovo State Medical University,
Ministry of Health of Russia. E-mail: ol.an.t@yandex.ru. ORCID: 0000-0002-6537-3460. 22a Voroshilova str., Kemerovo, 650056, Russian Federation.

For citation: Artymuk N.V., Tachkova O.A. Vitamin D deficiency and women’s reproductive health.
Akusherstvo i Ginekologiya / Obstetrics and gynecology. 2021; 3: 189-195 (in Russian)
https://dx.doi.org/10.18565/aig.2021.3.189-195

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