Fetal bradyarrythmia in obstetric practice: diagnosis, possibilities for therapeutic approaches, and prevention

Potapova A.A., Timoshina I.V., Khodzhaeva Z.S., Bockeria E.L.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Until recently, fetal arrhythmias have been a cause of stillbirths and neonatal and infant deaths in many cases, which has given rise to a new interdisciplinary direction in perinatology - fetal cardiology-arrhythmology. Unlike fetal tachyarrhythmias that are actively treatable, even timely therapy for bradycardia does not always provide a favorable outcome. In this connection, to predict and prevent fetal atrioventricular block are still the subject of active study. The review includes scientific publications (mainly systematic reviews and meta-analyses) by foreign and Russian authors over the past 10 years, which have been found in the Pubmed database and other available search systems: Cochrane, Web of Science, MEDLINE, and Google Scholar. The paper presents the modern ideas about the incidence and pathogenesis of fetal bradyarrhythmias and considers various therapeutic and preventive approaches.
Conclusion. Further clinical and laboratory studies are needed to develop a comprehensive examination of and optimal management tactics for pregnant women with different types of fetal bradyarrhythmias

Keywords

neonatal lupus
congenital atrioventricular heart block
fetal bradycardia
anti-Ro antibodies
anti-La antibodies

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Received 07.02.2020

Accepted 30.10.2020

About the Authors

Alyona A. Potapova, graduate student of high risk pregnancy department, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. E-mail: doc.PotapovaAA@yandex.ru 117997, Russia, Moscow, Ac. Oparina str., 4.
Irina V. Timoshina, Ph.D., Researcher of high risk pregnancy department, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russian Federation. E-mail: timoshinairina@yandex.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
Zulfiya S. Khodzhaeva, M.D., Professor, Deputy Director of obstetrics institute, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation. Tel.: +7(916)407-75-67. E-mail: zkhodjaeva@mail.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.
Ekaterina L. Bokeriya, M.D., Professor, Head of the department of pathology of newborn and premature babies, Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russian Federation. E-mail: e_bokeriya@oparina4.ru. 117997, Russia, Moscow, Ac. Oparina str., 4.

For citation: Potapova A.A., Timoshina I.V., Khodzhaeva Z.S., Bockeria E.L. Fetal bradyarrythmia in obstetric practice: diagnosis, possibilities for therapeutic approaches, and prevention.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 1: 12-17 (in Russian)
https://dx.doi.org/10.18565/aig.2021.1.12-17

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