Favorable outcome of the extremely severe course of the new coronavirus infection COVID-19 during pregnancy in the presence of overall lung damage, acute myocarditis, and myocardial infarction

DOI

https://dx.doi.org/10.18565/aig.2021.10.179-186

Voropaeva E.E., Ishchenko L.S., Mikhailova S.A., Aleksandrov D.I., Khaidukova Yu.V., Kazachkova E.A., Kazachkov E.L.
1) South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia; 2) Regional Clinical Hospital No. 2, Chelyabinsk, Russia

Background: The new coronavirus infection (NCI) COVID-19 in pregnant women occurs in various types from asymptomatic to extremely severe ones with the development of multiple organ failure and sepsis. SARS-CoV-2 infection occurs at the cellular level through viral binding to angiotensin-converting enzyme 2 (ACE2) receptors, the presence of which in the myocardium and vascular endothelial cells explains the mechanism of severe cardiovascular complications of NCI. The development of the latter has been demonstrated in few studies, whereas favorable outcomes for the mother and fetus in the presence of overall lung damage and acute coronary syndrome have not been reflected in the literature.
Case report: The article describes and analyzes the favorable outcome of extremely severe NCI Covid-19 in a pregnant woman with overall lung damage, the development of acute myocarditis and myocardial infarction in the postpartum period.
Conclusion: The timely referral of a pregnant woman with extremely severe NCI COVID-19 to the obstetric hospital of an infectious diseases hospital for patients with NCI COVID-19 for specialized medical care using a multidisciplinary approach, as well as the consideration of possible cardiac complications in this disease, their timely diagnosis and correction made it possible to effectively prevent an unfavorable outcome for the mother and fetus.

COVID-19

new coronavirus infection

pregnancy

overall lung damage

coagulopathy

acute myocarditis

myocardial infarction

Full text (in Russian)

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Received 27.04.2021

Accepted 18.06.2021

Ekaterina E. Voropaeva, Dr. Med. Sci., Associate Professor, Professor of the Department of Pathological Anatomy and Forensic Medicine, South Ural State
Medical University, Ministry of Health of the Russian Federation; Deputy Chief Physician for Obstetrics and Gynecology, Regional Clinical Hospital No. 2,
+7(351)217-70-42, katya_voropaeva@mail.ru, 64 Vorovsky str., Chelyabinsk, 454000, Russia.
Lyudmila S. Ishchenko, PhD, Associate Professor, Associate Professor of the Department of Obstetrics and Gynecology, South Ural State Medical University,
Ministry of Health of the Russian Federation, +7(351)741-22-83, +7(919)352-91-14, lyudalyn@mail.ru, 64 Vorovsky str., Chelyabinsk, 454000, Russia.
Svetlana A. Mikhailova, Dr. Med. Sci., Chief Physician of the Regional Clinical Hospital No. 2; Professor of the Department of Faculty Surgery, South Ural State
Medical University, Ministry of Health of the Russian Federation, +7(902)867-65-88, samih@bk.ru, 18 Gagarina str., Chelyabinsk, 454000, Russia.
Demyan I. Alexandrov, Head of the Department of Anesthesiology and Resuscitation No. 2, Regional Clinical Hospital No. 2, +7(351)217-70-42, dema_alex@mail.ru,
18 Gagarina str., Chelyabinsk, 454000, Russia.
Yulia V. Khaydukova, Head of the 2nd Obstetric Department, Regional Clinical Hospital No. 2, +7(351)217-70-42, jumi.06@mail.ru,
18 Gagarina str., Chelyabinsk, 454000, Russia.
Ella A. Kazachkova, Dr. Med. Sci., Professor, Professor of the Department of Obstetrics and Gynecology, South Ural State Medical University, Ministry of Health
of the Russian Federation, +7(912)478-62-90, doctorkel@narod.ru, 64 Vorovsky str., Chelyabinsk, 454000, Russia.
Evgeny L. Kazachkov, Dr. Med. Sci., Professor, Head of the Department of Pathological Anatomy and Forensic Medicine, South Ural State Medical University,
Ministry of Health of the Russian Federation, +7(351)232-01-45, doctorkel@narod.ru, 64 Vorovsky str., Chelyabinsk, 454000, Russia.
Corresponding author: Lyudmila S. Ishchenko, lyudalyn@mail.ru

Authors' contributions: Voropaeva E.E., Mikhailova S.A., Aleksandrov D.I., Khaidukova Yu.V. – material collection and processing; Voropaeva E.E., Ishchenko L.S. – analysis of the findings; writing the article; Kazachkov E.L. – review of publications on the topic of the article; Kazachkova E.A. – editing.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The publication has been prepared without sponsorship.
Patient Consent for Publication: The patient provided informed consent for the publication of her data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Voropaeva E.E., Ishchenko L.S., Mikhailova S.A., Aleksandrov D.I.,
Khaidukova Yu.V., Kazachkova E.A., Kazachkov E.L. Favorable outcome of the extremely severe course of the new coronavirus infection COVID-19 during pregnancy in the presence
of overall lung damage, acute myocarditis, and myocardial infarction.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 10: 179-186 (in Russian)
https://dx.doi.org/10.18565/aig.2021.10.179-186

Favorable outcome of the extremely severe course of the new coronavirus infection COVID-19 during pregnancy in the presence of overall lung damage, acute myocarditis, and myocardial infarction

Voropaeva E.E., Ishchenko L.S., Mikhailova S.A., Aleksandrov D.I., Khaidukova Yu.V., Kazachkova E.A., Kazachkov E.L.

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