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Obstetrics and Gynegology2020№4
Asthenozoospermia and proteomic factors regulating...

Asthenozoospermia and proteomic factors regulating sperm motility

DOI
https://dx.doi.org/10.18565/aig.2020.4.37-44

Shatylko T.V., Gamidov S.I., Frankevich V.E., Starodubtseva N.L., Gasanov N.G., Tambiev A.Kh.

1 Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia; 2 I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia
Asthenozoospermia is reduced sperm motility that is often found when testing semen from men of infertile couples. Asthenozoospermia can be caused by various diseases and lifestyle factors, but the specific pathogenetic mechanisms of impaired sperm motility remain not fully investigated. To date, data have been accumulated in proteomic studies, which indicate that numerous protein molecules that realize various biological functions are regulators of the motility of male germ cells. Further study of proteomic mobility regulators will more accurately identify the etiology of asthenozoospermia, objectify its diagnosis, and, in the future, develop targeted therapies for male infertility, which are aimed at increasing the number of motile spermatozoa in the ejaculate.

Keywords

asthenozoospermia
ejaculate proteome
male infertility
seminal plasma
Full text (in Russian)

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Received 29.01.2020

Accepted 07.02.2020

About the Authors

Taras V. Shatylko, candidate of medical science, urologist of andrology and urology department of National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Tel.: +7(927)620-49-25. E-mail: dialectic.law@gmail.com
4, Oparina str., Moscow, 117997, Russian Federation.
Safar I. Gamidov, doctor of medical science, chief urologist of National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, professor of obstetrics, gynecology and perinatology department of Sechenov University. Tel.: +7(495)531-44-44, E-mail: safargamidov@yandex.ru
4, Oparina str., Moscow, 117997, Russian Federation.
Vladimir E. Frankevich, candidate of physical and technical science, chief of department of systemic biology in reproduction of National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Tel.: +7(495)531-44-44, E-mail: v_frankevich@oparina4.ru
4, Oparina str., Moscow, 117997, Russian Federation.
Natalia L. Starodubtseva, candidate of biological science, chief of proteomics and metabolomics laboratory in human reproduction of National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Tel.: +7(495)531-44-44, E-mail: n_starodubtseva@oparina4.com
4, Oparina str., Moscow, 117997, Russian Federation.
Natig G. Gasanov, urologist of andrology and urology department of National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Tel.: +7(495)531-44-44, E-mail: natiqhasan@gmail.com
4, Oparina str., Moscow, 117997, Russian Federation.
Alikhan Kh. Tambiev, postgraduate student at the Department Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education of the Sechenov University. Tel.: +7(915)499-69-45, E-mail: dr.tambiev@gmail.com
2-4, Bolshaya Pirogovskaya str., Moscow, 119991, Russian Federation.

For citation: Shatylko T.V., Gamidov S.I., Frankevich V.E., Starodubtseva N.L., Gasanov N.G., Tambiev A.Kh. Asthenozoospermia and proteomic factors regulating sperm motility.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 3: 37-44. (In Russian).
https://dx.doi.org/10.18565/aig.2020.4.37-44

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