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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2020№8
Abnormal uterine bleeding in women...

Abnormal uterine bleeding in women of reproductive age and premenopause

DOI
https://dx.doi.org/10.18565/aig.2020.8.29-38

Solovyeva A.V., Chegus L.A.

1) Department of Obstetrics and Gynecology with Course of Perinatology, Medical Institute, Peoples’ Friendship University of Russia, Ministry of Education and Science of the Russian Federation, Moscow, Russia; 2) Department of Obstetrics and Gynecology, Khanty Mansiysk State Medical Academy, Khanty-Mansiysk, Khanty-Mansiysk Autonomous Okrug–Yugra, Russia
Abnormal uterine bleeding (AUB) occurs in 3–30% of women and its prevalence depends on the living standards of a patient and the state of health care in different countries. This is most common in women with obesity, polycystic ovary syndrome, in premature ovarian failure and during premenopause. The review describes the efficacy of medicines, the frequency of complications (for example, the risk of venous thromboembolism when taking combined oral contraceptives, depending on the type of progestogen), and contraindications. Progestogens are widely used for the treatment of AUB since they neutralize progesterone deficiency and anovulation and have anti-inflammatory effects. In Russia, dydrogesterone is a progestogen with registered indications, such as irregular menstruation, dysfunctional uterine bleeding, endometriosis, secondary amenorrhea, premenstrual syndrome, and hormone replacement therapy.
Conclusion. Dydrogesterone therapy has been shown to be significantly effective in normalizing irregular menstrual cycles, including this in randomized controlled trials. Considering that dydrogesterone is a metabolically neutral drug; it lacks androgenic, glucocorticoid, mineralocorticoid, and antigonadotropic effects; it does not aggravate insulin resistance and dyslipidemic disorders or affect the hemostatic system; it can be recommended for a wide population of women with AUB.

Keywords

abnormal uterine bleeding
diagnosis
treatment
dydrogesterone
Full text (in Russian)

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Received 17.05.2020

Accepted 03.08.2020

About the Authors

Alina V. Solovyeva, MD, professor of the Department of Obstetrics Gynecology with a course of perinatology, Peoples’ Friendship University of Russia,
Ministry of Education and Science of Russia. E-mail: av_soloveva@mail.ru. ORCID: 0000-0001-6711-1563.
117198, Russia, Moscow, Miklukho-Maklaya str., 8.
Larisa A. Chegus, PhD, MD, Department of Obstetrics and Gynecology, BI «Khanty Mansiysk State Medical Academy». E-mail: lchegus@mail.ru.
ORCID: 0000-0002-9698-8038. 628011, Russia, Khanty Mansiysk city, Yamskaya str., 12/91.

For citation: Solovyeva A.V., Chegus L.A. Abnormal uterine bleeding in women of reproductive age and premenopause.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 8: 29-38 (in Russian).
https://dx.doi.org/10.18565/aig.2020.8.29-38

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