Androgen deficiency in women of different ages: diagnosis and treatment

Romanov A.Yu., Gavisova A.A., Dolgushina N.V.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
The paper analyzes the data available in the literature on the female metabolism of androgens and their effect on folliculogenesis and oogenesis and sexual function in women of different ages. It covers the problems with the diagnosis of androgen deficiency and the causes of the latter. The use of androgens as therapy in the assisted reproductive technology programs for adrenal insufficiency and in postmenopause has been investigated. Further investigations should be aimed to define clear indications for androgen therapy, the most appropriate administration route, and dosage.


androgen deficiency
androgen therapy
adrenal insufficiency
dehydroepiandrosterone sulfate
assisted reproductive technology
in vitro fertilization


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Received 18.11.2019

Accepted 29.11.2019

About the Authors

Andrey Yu. Romanov, postgraduate student, specialist of R&D Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, Tel. +7 (903)158-94-00. E-mail:
4 . Oparina str., Moscow, 117997, Russian Federation
Alla A. Gavisova, Ph.D., Senior Researcher of the 1st Gynecology Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, E-mail: 4 . Oparina str., Moscow, 117997, Russian Federation.
Nataliya V. Dolgushina, M.D., Ph.D., Professor, Head of R&D Department, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation E-mail: 4 . Oparina str., Moscow, 117997, Russian Federation

For reference: Romanov A.Yu., Gavisova A.A., Dolgushina N.V.
Androgen deficiency in women of different ages: diagnosis and treatment.
Akusherstvo i Ginekologiya/ Obstetrics and Gynecology. 2020; 5: 58-64 (In Russian).

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