Obstetric and neonatal outcomes of assisted reproductive technology programs using donor oocytes

Mamedova T.R., Syrkasheva A.G., Dolgushina N.V.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow
The higher infertile marriage rate in economically developed countries has necessitated the emergence and development of assisted reproductive technologies (ART). It should be noted that to date, more than 23% of the ART programs have been implemented in women aged 40 years and older. At the same time, the effectiveness of ART techniques using autologous oocytes (AOs) in this age group of patients is about 10%, whereas this indictor for women 45 years of age and older decreases to 1% or less. Over the past 15 years, the number of ART cycles using donor oocytes (DOs) has been steadily increasing. The most common pregnancy complications after cycles using DOs are preterm birth, hypertensive disorders, and preeclampsia. In recent years, there have been data in the literature that the frequency of obstetric complications is higher in patients with DOs than in those with AOs, even after taking confounders into account. That is, the use of DOs is an independent risk factor for obstetric complications. This review of the literature presents current views on the obstetric and neonatal outcomes of ART cycles using DOs.

Keywords

assisted reproductive technologies
donor oocytes
pregnancy complications
preeclampsia
premature birth
hypertensive disorders

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Received 19.11.2019

Accepted 29.11.2019

About the Authors

Tamella R. Mamedova, M. D., PhD student of the IVF Department
National Research Center for Obstetrics, Gynecology and Perinatology. E-mail: mamedovat91@gmail.com
4 Oparin str, 117997, Moscow, Russia
Anastasia G. Syrkasheva, M.D., Ph.D., Senior Researcher of the IVF Department
National Research Center for Obstetrics, Gynecology and Perinatology. Теl.: +7 (926)363-17-20. E-mail: a_syrkasheva@oparina4.ru
4 Oparin str, 117997, Moscow, Russia
Nataliya V. Dolgushina, M.D., Ph.D., M.P.H., Professor, Deputy Director, Head of R&D Department Kulakov NMRC OGP, Ministry of Healthcare of the Russian Federation.
Tel.: +7 (495) 438-49-77. E-mail: n_dolgushina@oparina4.ru.
4 Oparin str, 117997, Moscow, Russia

For citation: Mamedova T.R., Syrkasheva A.G., Dolgushina N.V. Obstetric and neonatal outcomes of assisted reproductive technology programs using donor oocytes.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 4: 31-36. (In Russian).
https://dx.doi.org/10.18565/aig.2020.4.31-36

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