About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
Reviewing
Procedure for reviewingReviewers 2023-2024
ISSN 0300-9092 (Print)
ISSN 2412-5679 (Online)
About
The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
ArchiveEthical StandardsSubscription
For authors
InstructionsInformed consent policyContract offerEASE GuidelinesICJME CriteriaWAME Recommendations on ChatGPT and Chatbots in Relation to Scholarly Publications
Reviewing
Procedure for reviewingReviewers 2023-2024
Logout
Obstetrics and Gynegology2026№5

Comparative analysis of clinical characteristics in Syrian women with uterine fibroids stratified by body mass index

DOI
https://dx.doi.org/10.18565/aig.2025.335

Alali O.M., Khaddam W.M., Churnosov M.I.

1) Belgorod State National Research University, Belgorod, Russia; 2) Homs University, Homs, Syria

Objective. To compare the clinical characteristics of Syrian women with uterine fibroid (UF) stratified by body mass index (BMI).
Materials and methods. 500 Syrian women with UF, ages 22–83, were included. They were split into three groups according to their BMI: 174 patients had BMI<25 kg/m2, 166 patients had BMI 25–29.99 kg/m2, and 160 patients had BMI≥30 kg/m2. A questionnaire of 65 items was used to gather data on the clinical characteristics and risk factors for the onset of UF. To analyze data was used SPSS version 30.
Results. Indicated that the rise in BMI of the participants was accompanied by a statistically significant increase in each of the age due to an increase in the proportion of women over 50 years of age, the elapsed time from the last birth, the number of births, the summary number of children, the usage an intrauterine device as a contraceptive method, and the incidence of hypertension, diabetes, and endometrial hyperplasia, moreover undergoing myomectomy and hysterectomy. While a statistically significant decrease was observed for the age at the first birth and age at first menstruation with a rise in BMI of these participants. The characteristics of fibromatous nodes in women with BMI 25–29.99 kg/m2 are their predominantly intramural location and large size, whereas in women with BMI<25 kg/m2 and BMI≥30 kg/m2, the nodes were mostly located subserosally and had smaller sizes. Similarly, women with BMI<25 kg/m2 often have pedunculated nodes and a combination of subserosal and intramural nodes, and women with BMI≥30 kg/m2 have submucosal nodes.
Conclusion. This study showed that Syrian women with different BMIs have distinct clinical characteristics of UFs. That will provide further insight into how they are affected by variations in BMI, and consequently, how these variations influence the risk and prevalence of UFs, which is helpful in their diagnosis, prevention, and symptom relief.

Authors' contributions. Alali O.M., Khaddam W.M., Churnosov M.I. – conception and design of the study; Alali O.M. – data collection and analysis, manuscript drafting; Churnosov M.I. – manuscript editing.
Conflicts of interest. The authors have no conflicts of interest to declare.
Funding. There was no funding for this study.
Ethical Approval. The study was reviewed and approved by the Research Ethics Committee of the Belgorod State National Research University.
Patient Consent for Publication. All patients provided informed consent for the publication of their data.
Authors' Data Sharing Statement. The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.
For citation: Alali O.M., Khaddam W.M., Churnosov M.I. Comparative analysis of 
clinical characteristics in Syrian women with uterine fibroids stratified by body mass index.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (5): 121-132 (in Russian)
https://dx.doi.org/10.18565/aig.2025.335

Keywords

uterine fibroid
leiomyoma
body mass index
obesity
overweight
risk factor
Full text (in Russian)

References

  1. Алали О.М., Чурносов М.И. Полногеномные исследования миомы матки. Акушерство и гинекология. 2023; 7: 28-38. [Alali O.M., Churnosov M.I. Genome-wide studies of uterine leiomyomas. Obstetrics and Gynecology. 2023; (7): 28-38 (in Russian)]. https://dx.doi.org/10.18565/aig.2023.156
  2. Ponomarenko I., Reshetnikov E., Polonikov A., Verzilina I., Sorokina I., Yermachenko A. et al. Candidate genes for age at menarche are associated with uterine leiomyoma. Front. Genet. 2021; 11: 512940. https://dx.doi.org/10.3389/fgene.2020.512940
  3. Алали О.М., Хаддам В.М., Чурносов М.И. Клинические характеристики сирийских женщин с лейомиомой матки. Акушерство и гинекология. 2025; 7: 76-83. [Alali O.M., Khaddam W.M., Churnosov M.I. Сlinical characteristics of Syrian women with uterine leiomyoma. Obstetrics and Gynecology. 2025; (7): 76-83 (in Russian)]. https://dx.doi.org/10.18565/aig.2025.59
  4. Пономаренко И.В., Полоников А.В., Чурносов М.И. Полиморфные локусы гена LHCGR, ассоциированные с развитием миомы матки. Акушерство и гинекология. 2018; 10: 86-91. [Ponomarenko I.V., Polonikov A.V., Churnosov M.I. Polymorphic LHCGR gene loci associated with the development of uterine fibroids. Obstetrics and Gynecology. 2018; (10): 86-91 (in Russian)]. https://dx.doi.org/10.18565/aig.2018.10.86-91
  5. Qin H., Lin Z., Vásquez E., Luan X., Guo F., Xu L. Association between obesity and the risk of uterine fibroids: a systematic review and meta-analysis. J. Epidemiol. Community Health. 2021; 75: 197-204. https://doi.org/10.1136/jech-2019-213364
  6. Maghraby N., El Noweihi A.M., El-Melegy N.T., Mostafa N.A., Abbas A.M., El-Deek H.E. et al. Increased expression of fibroblast activation protein is associated with autophagy dysregulation and oxidative stress in obese women with uterine fibroids. Reprod. Sci. 2021; 29(2): 1-2. https://dx.doi.org/10.1007/s43032-021-00810-0
  7. Alali O.M., Churnosov M.I. The etiopathogenesis of uterine leiomyomas: a review. Gynecology. 2023; 25(1): 22-30. https://dx.doi.org/10.26442/20795696.2023.1.201827
  8. Пономаренко М.С., Решетников Е.А., Пономаренко И.В., Чурносов М.И. Факторы риска развития миомы матки. Акушерство и гинекология. 2024; 3: 20-7. [Ponomarenko M.S., Reshetnikov E.A., Ponomarenko I.V., Churnosov M.I. Risk factors for the development of uterine fibroids. Obstetrics and Gynecology. 2024; (3): 20-7 (in Russian)]. https://dx.doi.org/10.18565/aig.2023.275
  9. Sharami S.H., Fallah Arzpeyma S., Shakiba M., Montazeri S., Milani F., Kazemi S. et al. Relationship of uterine fibroids with lipid profile, anthropometric characteristics, subcutaneous and preperitoneal fat thickness. Arch. Iran. Med. 2019; 22(12): 716-21.
  10. Pan H., Qin F., Deng F. Clinical value of body mass index and waist-hip ratio in clinicopathological characteristics and prognosis of uterine leiomyomata. Evid. Based Complement. Alternat. Med. 2021; 2021: 8156288. https://dx.doi.org/10.1155/2021/8156288
  11. Пономаренко М.С., Решетников Е.А., Пономаренко И.В., Чурносов М.И. Этиопатогенетические механизмы развития миомы матки. Акушерство и гинекология. 2024; 1: 34-41. [Ponomarenko M.S., Reshetnikov E.A., Ponomarenko I.V., Churnosov M.I. Etiopathogenetic mechanisms of uterine fibroids development. Obstetrics and Gynecology. 2024; (1): 34-41 (in Russian)]. https://dx.doi.org/10.18565/aig.2023.241
  12. Gürbüz T., Yardımcı O., Udum S., Günay T. The relationship between body mass index and clinical complications among patients undergoing myomectomy. J. Surg. Med. 2020; 4(11): 1027-30. https://dx.doi.org/10.28982/josam.805122
  13. Lee J.E., Song S., Cho E., Jang H.J., Jung H., Lee H.Y. et al. Weight change and risk of uterine leiomyomas: Korea Nurses’ Health Study. Cur. Med. Res. Opin. 2018; 34(11): 1913-9. https://dx.doi.org/10.1080/03007995.2018.1462783
  14. Haan Y.C., Diemer F.S., Van der Woude L., Van Montfrans G.A., Oehlers G.P., Brewster L.M. The risk of hypertension and cardiovascular disease in women with uterine fibroids. J Clin Hypertens (Greenwich). 2018; 20(4): 718-26. https://dx.doi.org/10.1111/jch.13253
  15. Пономаренко И.В., Чурносов М.И. Современные представления об этиопатогенезе и факторах риска лейомиомы матки. Акушерство и гинекология. 2018; 8: 27-32. [Ponomarenko I.V., Churnosov M.I. Current views on the etiopathogenesis and risk factors of uterine leiomyoma. Obstetrics and Gynecology. 2018; (8): 27-32 (in Russian)]. https://dx.doi.org/10.18565/aig.2018.8.27-32
  16. Muawad R., Dabbagh R., Sabr Y. Association of health and lifestyle factors with uterine fibroids among Saudi women: a case–control study. J. Taibah Univ. Med. Sci. 2022; 17(6): 1039-46. https://dx.doi.org/10.1016/j.jtumed.2022.06.005
  17. Keizer A.L., Semmler A., Kok H.S., van Kesteren P.J., Huirne J.A., Hehenkamp W.J. Modifiable prognostic factors in uterine fibroid development: a systematic review of literature. J. Obstet. Gynaecol. 2024; 44(1): 2288225. https://dx.doi.org/10.1080/01443615.2023.2288225
  18. Donnez J., Dolmans M.M. Uterine fibroid management: from the present to the future. Hum. Reprod. Update. 2016; 22(6): 665-86. https://dx.doi.org/10.1093/humupd/dmw023
  19. Wise L.A., Laughlin-Tommaso S.K. Epidemiology of uterine fibroids – from menarche to menopause. Clin. Obstet. Gynecol. 2016; 59(1): 2-24. https://dx.doi.org/10.1097/GRF.0000000000000164
  20. Ponomarenko M.S., Reshetnikov E.A., Churnosova M.M., Reshetnikova Y.N., Churnosov V.I., Ponomarenko I.V. Comorbidity and syntropy of benign proliferative diseases of the female reproductive system: non-genetic, genetic, and epigenetic factors (review). Research Results in Biomedicine. 2023; 9(4): 544-56. https://dx.doi.org/10.18413/2658- 6533-2023-9-4-0-9
  21. Stewart E.A., Cookson C.L., Gandolfo R.A., Schulze‐Rath R. Epidemiology of uterine fibroids: a systematic review. BJOG. 2017; 124(10): 1501-12. https://dx.doi.org/10.1111/1471-0528.14640
  22. Nwonuma C., Irokanulo E., Bamgboye F., Akinduko A., Okeniyi F., Eigbe C. Uterine fibroid: risk factors and therapeutic interventions. In: International conference on science, engineering and business for driving sustainable development goals (SEB4SDG), 2024 Apr. 2-4. Omu-aran;2024: 1-10.
  23. Shabahat Ahmed A., Kiran Sharif M.A. Prevalence and clinical characteristics of uterine fibroids in women of reproductive age in district hyderabad. The Research of Medical Science Review. 2025; 3(1): 635-47.
  24. Pavone D., Clemenza S., Sorbi F., Fambrini M., Petraglia F. Epidemiology and risk factors of uterine fibroids. Best Pract. Res. Clin. Obstet. Gynaecol. 2018; 46: 3-11. https://dx.doi.org/10.1016/J.BPOBGYN.2017.09.004
  25. Zapata L.B., Whiteman M.K., Tepper N.K., Jamieson D.J., Marchbanks P.A., Curtis K.M. Intrauterine device use among women with uterine fibroids: a systematic review. Contraception. 2010; 82(1): 41-55. https://dx.doi.org/10.1016/j.contraception.2010.02.011
  26. Пономарева Т.А. Генетические варианты глобулина, связывающего половые гормоны, и гормональный профиль больных генитальным эндометриозом. Научные результаты биомедицинских исследований. 2025; 11(1): 75-90. [Ponomareva T.A. Genetic variants of sex hormone-binding globulin and hormonal profile in patients with genital endometriosis. Research Results in Biomedicine. 2025; 11(1): 75-90 (in Russian)]. https://dx.doi.org/10.18413/2658-6533-2025-11-1-0-4
  27. Ponomarenko M.S. The relationship between the genetic determinants of SHBG and the hormonal profile of patients with uterine fibroids. Research Results in Biomedicine. 2025; 11(4): 628-42. https://dx.doi.org/10.18413/2658-6533-2025-11-4-0-3
  28. Alsudairi H.N., Alrasheed A.T., Dvornyk V. Estrogens and uterine fibroids: an integrated view. Research Results in Biomedicine. 2021; 7(2): 156-63. https://dx.doi.org/10.18413/2658-6533-2021-7-2-0-6
  29. Чурносов В.И. Ассоциации полиморфных локусов генов-кандидатов с уровнем половых гормонов у больных гиперплазией эндометрия. Научные результаты биомедицинских исследований. 2025;11(2):243-262. [Churnosov V.I. Associations of polymorphic loci of candidate genes with the level of sex hormones in patients with endometrial hyperplasia. Research Results in Biomedicine. 2025; 11(2): 243-62 (in Russian)]. https://dx.doi.org/10.18413/2658-6533-2025-11-2-0-3
  30. Harmon Q.E., Patchel S., Denslow S., Wegienka G., Baird D.D. Body mass index and uterine fibroid development: a prospective study. The Journal of Clinical Endocrinology & Metabolism. 2024; 109(11): e2016-23. https://dx.doi.org/10.1210/clinem/dgae036
  31. Bray M.J., Torstenson E.S., Jones S.H., Edwards T.L., Edwards D.R. Evaluating risk factors for differences in fibroid size and number using a large electronic health record population. Maturitas. 2018; 114: 9-13. https://dx.doi.org/10.1016/j.maturitas.2018.05.003
  32. Ponomarenko M., Reshetnikov E., Churnosova M., Aristova I., Abramova M., Novakov V. et al. Genetic variants linked with the concentration of sex hormone-binding globulin correlate with uterine fibroid risk. Life (Basel). 2025; 15(7): 1150. https://dx.doi.org/10.3390/life15071150

Received 18.11.2025

Accepted 28.04.2026

About the Authors

Ola Mohamad Alali, PhD student, Belgorod State National Research University, 85 Pobedy str., 308015, Belgorod, Russia, alali@bsuedu.ru,
https://orcid.org/0000-0003-4370-6719
Walid Khaddam, Doctor of Microbiology, Homs University, Homs, Syria, wkhaddam@homs-univ.edu.sy, https://orcid.org./0000-0001-6771-2211
Mikhail I. Churnosov, Dr. Med. Sci., Professor, Head of the Department of Medical and Biological Disciplines, Belgorod National Research University, 85 Pobedy str.,
308015, Belgorod, Russia, churnosov@bsuedu.ru, https://orcid.org/ 0000-0003-1254-6134

Similar Articles

№12 / 2024
Tikhomirov A.L., Orazov M.R., Melkozerova O.A., Smetnik A.A., Ermakova E.I., Katkova N.Yu., Bezhenar V.F., Antropova E.Yu., Rymashevsky A.N., Mikhelson A.A., Baranova E.S., Grigorian A.E.
Efficacy and safety of mifepristone in patients with uterine fibroids
№10 / 2025
Rudyakova V.S., Khripun I.A., Kuzmenko N.A.
Modern aspects of preconception care and management of pregnant women with obesity and diabetes mellitus
№1 / 2025
Rosyuk E.A., Oboskalova T.A., Zornikov D.L., Ten A.R., Askerova M.G., Sevostyanova O.Yu., Soloviev D.V., Kudimov A.A., Bikbulatova E.R., Averchenkova E.A.
Clinical and medical history characteristics of pregnant women with different cervical cytology results
№7 / 2025
Dikke G.B., Dukhanin A.S.
Myoinositol and D-chiroinositol in the treatment of patients with anovulatory infertility associated with metabolic disorders: debatable issues
№7 / 2024
Babaeva N.I., Atalyan A.V., Dmitriev V.Ya., Suturina L.V.
Risk factors for uterine fibroids: a bibliometric analysis
By continuing to use our site, you consent to the processing of cookies that ensure the proper functioning of the site.