Use of multicomponent biomimetic materials of extracellular matrix in regenerative medicine: from biology to clinical practice
Boris D.A., Apolikhina I.A.
Chronic dystrophic processes – genitourinary syndrome of menopause (GSM), stress urinary incontinence (SUI), lichen sclerosus, post-radiation and post-operative cicatricial skin changes – represent a significant medical and social problem leading to a persistent decrease in the quality of life. Such traditional treatment methods as local hormonal therapy or surgical interventions often affect symptomatic alterations and have a number of limitations and side effects. Implementation of the principles of regenerative medicine offers opportunities for pathogenetic treatment by activating the body's own reparative processes. In the modern paradigm, the key tool of this approach is multicomponent biomimetic materials of the extracellular matrix (ECM), reproducing its structure and function.
In this article we analyze the ECM line of multicomponent biomimetic materials produced in Russia (injectable biopolymer hydrogels) for the treatment of urogynecological pathologies. The composition, mechanisms of biomimetic action, and strategy for personalized modification selection depending on the clinical scenario are also discussed in detail. According to available clinical data, hydrogels are highly effective in restoring tissue trophism in GSM, as a regenerating agent for mild to moderate SUI, and in the treatment of sclerotic and cicatricial processes. Here we also touch upon safety issues, regulatory aspects, and prospects for technology development, including the creation of combined cell-engineered formations.
Conclusion: Multicomponent biomimetic hydrogels are a promising class of agents for minimally invasive, pathogenetically substantiated correction of a wide range of chronic degenerative diseases in urogynecology.
Authors’ contributions: Boris D.A., Apolikhina I.A. – study design, data collection, relevant publications’ review, manuscript writing.
Conflicts of interest: The authors declare no conflicts of interest.
Funding: The study had no sponsorship support.
For citation: Boris D.A., Apolikhina I.A. Use of multicomponent biomimetic materials of extracellular matrix
in regenerative medicine: from biology to clinical practice.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (7): 176-181 (in Russian)
https://dx.doi.org/10.18565/aig.2026.08
Keywords
regenerative medicine
extracellular matrix
biomimetic
hydrogel
genitourinary syndrome of menopause
stress urinary incontinence
lichen sclerosus
cicatricial skin changes
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Received 16.01.2026
Accepted 06.04.2026
About the Authors
Daiana A. Boris, PhD, obstetrician-gynecologist, doctor of ultrasound diagnostics, Senior Researcher at the Department of Aesthetic Gynecology and Rehabilitation, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow,Ac. Oparin str., 4, dayana_boris@mail.ru, SPIN: 4832-0643, https://orcid.org/0000-0002-0387-4040
Inna A. Apolikhina, Dr. Med. Sci., Professor, Head of the Department of Aesthetic Gynecology and Rehabilitation, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ac. Oparin str., 4; Professor, Department of Obstetrics, Gynecology, Perinatology and Reproductology, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), i_apolikhina@oparina4.ru,
SPIN: 6282-7435, https://orcid.org/0000-0002-4581-6295
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