Photodynamic therapy as a contemporary treatment approach to Asherman’s syndrome

DOI

https://dx.doi.org/10.18565/aig.2025.379

Pasman N.P., Selyunina N.A., Panova S.V., Karpets I.O., Sayapina S.I., Veretelnikova T.V., Shifon S.A., Zhdanova E.A., Serov V.N.
1) Novosibirsk National Research State University, Novosibirsk, Russia; 2) Pasman Clinic, Novosibirsk, Russia; 3) Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, Moscow, Russia

Objective: To assess the clinical and reproductive outcomes in patients with Asherman’s syndrome (AS) using hysteroscopic adhesiolysis (HA) in combination with photodynamic therapy (PDT).
Materials and methods: We analyzed case series of 16 patients aged 25–49 years (the median age – 31.6 years). The diagnosis of chronic endometritis was verified in the whole cohort of patients; 75% of patients experienced infertility. According to AFS classification Asherman’s syndrome stage I was in 43.8% of patients, stage II was in 37.5%, and stage III was in 18.8%. All patients underwent hysteroscopic adheolysis, endometrial biopsy, intracavitary photosensibilization with subsequent endometrial laser therapy (662 nm, ~30–40 J/cm²). Anti-adhesion barriers and hormonal balance support/IUD were used according to indications. Analysis of case series was performed according to the PROCESS guidelines.
Results: Menstrual function recovery was in 100% of patients after the first intervention. Repeat hysteroresectoscopy was performed in one patient due to recurrence of AS. Pregnancy occurred in 42% of patients within 2–9 months after HA in combination with or without PDT. No side effects of PDT were registered.
Conclusion: A combination of HA and PDT along with anti-adhesion barriers and hormonal balance support demonstrated positive dynamics of menstrual function recovery and promising reproductive outcomes in the small cohort of patients. Further randomized control trials as well as long-time observations are necessary to confirm the impacts of treatments on recurrence of AS/fertility.

Authors' contributions: Pasman N.M. – study concept and design, scientific editing of the manuscript; Selyunina N.A. – study design, manuscript editing; Panova S.V., Karpets I.O., Sayapina S.I. – colliection and analysis of published data and the clinical and anamnestic data, manuscript writing; Shifon S.A., Zhdanova E.A. – manuscript editing; Veretelnikova T.V. – submission of clinical and anmnestic data, and photographs; Serov V.N. – final editing of the manuscript.
Conflicts of interest: The authors declare that they have no conflicts of interest.
Funding: The study was carried out without any sponsorship.
Ethical Approval: The study was approved by the local Ethics Committee of V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia.
Patient Consent for Publication: The patients have signed informed consent for participation in the study and publication of their data.
Authors' Data Sharing Statement: The data supporting the findings of this study are available on request from the corresponding author after approval from the principal investigator.
For citation: Pasman N.P., Selyunina N.A., Panova S.V., Karpets I.O., Sayapina S.I.,
Veretelnikova T.V., Shifon S.A., Zhdanova E.A., Serov V.N. Photodynamic therapy as
a contemporary treatment approach to Asherman’s syndrome.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2026; (4): 143-148 (in Russian)
https://dx.doi.org/10.18565/aig.2025.379

Asherman’s syndrome

cyclic hormone therapy

anti-adhesion barriers

hysteroscopic adhesiolysis

photodynamic therapy

Full text (in Russian)

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Received 22.12.2025

Accepted 13.02.2026

Natalia M. Pasman, Dr. Med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Institute of Medicine and Medical Technologies, Faculty of Medicine and Psychology, Novosibirsk National Research State University, 630090, Russia, Novosibirsk, Pirogova str., 2, +7(913)916-25-91, https://orcid.org/0000-0002-6095-1954
Nadezhda A. Selyunina, obstetrician-gynecologist, Professor Pasman Clinic LLC; Teaching Assistant, Department of Obstetrics and Gynecology, Institute of Medicine and Medical Technologies, Novosibirsk National Research State University, 630090, Russia, Novosibirsk, Pirogova str., 2, Researcher ID Web of Science OAJ-2348-2025,
https://orcid.org/0009-0003-9958-6151
Sofya V. Panova, student at the Department of Obstetrics and Gynecology, Institute of Medicine and Medical Technologies, Faculty of Medicine and Psychology, Novosibirsk National Research State University, 630090, Russia, Novosibirsk, st. Pirogova, 2, https://orcid.org/0009-0005-6321-5652
Irina O. Karpets, student at the Department of Obstetrics and Gynecology, Institute of Medicine and Medical Technologies, Faculty of Medicine and Psychology, Novosibirsk National Research State University, 630090, Russia, Novosibirsk, Pirogova str., 2, https://orcid.org/0009-0008-6925-7388
Sofya I. Sayapina, student of the Department of Obstetrics and Gynecology, Institute of Medicine and Medical Technologies, Faculty of Medicine and Psychology, Novosibirsk National Research State University, 630090, Russia, Novosibirsk, Pirogova, 2, s.sayapina@g.nsu.ru, https://orcid.org/0009-0004-1174-1303
Tatyana V. Veretelnikova, obstetrician-gynecologist of the highest category, Professor Pasman Clinic LLC, Russia, Novosibirsk, https://orcid.org/0009-0007-1022-6985
Sofya A. Shifon, student at the Department of Obstetrics and Gynecology, Institute of Medicine and Medical Technologies, Faculty of Medicine and Psychology, Novosibirsk National Research State University, 630090, Russia, Novosibirsk, Pirogov str., 2, https://orcid.org/0009-0000-6461-5563
Elizaveta A. Zhdanova, student at the Department of Obstetrics and Gynecology, Institute of Medicine and Medical Technologies, Faculty of Medicine and Psychology, Novosibirsk National Research State University, 630090, Russia, Novosibirsk, Pirogova str., 2, https://orcid.org/0009-0001-9259-4840
Vladimir N. Serov, Dr. Med. Sci., Academician of the Russian Academy of Sciences, Professor, Chief Researcher, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia, 117997, Russia, Moscow, Ak. Oparina str., 4, +7(495)438-72-87,
https://orcid.org/0000-0001-6640-1235
Corresponding author: Sofya I. Sayapina, s.sayapina@g.nsu.ru

Photodynamic therapy as a contemporary treatment approach to Asherman’s syndrome

Pasman N.P., Selyunina N.A., Panova S.V., Karpets I.O., Sayapina S.I., Veretelnikova T.V., Shifon S.A., Zhdanova E.A., Serov V.N.

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