Bilateral lung lesion caused by benign metastasizing uterine myoma
Kotiv Kh.B., Khmelevskaia E.M., Nyuganen A.O., Okonechnikova D.V., Berlev I.V.
Background: Benign metastasizing leiomyoma is a rare condition characterized by the development of multiple slow-growing tumors composed of smooth muscle cells that form in atypical locations, primarily in lung tissue. These tumors are usually discovered after a considerable period of time following a myomectomy. This pathology is characterized by a mostly asymptomatic course, which makes it difficult to detect and often leads to accidental detection during examinations for other reasons. Despite the benign histological picture, the tumor can have a clinically aggressive course and can result in serious complications as well as increase in mortality.
Case report: The article presents a clinical case of bilateral lung lesion caused by benign metastasizing leiomyoma in a 50-year-old woman after myomectomy performed 11 years before. The disease was characterized by the latent course; the pulmonary metastases were accidentally detected during a routine examination. The therapeutic strategy included consistent surgical resections of the lesions in combination with surgical hormonal deprivation.
Conclusion: Due to the lack of approved clinical protocols for managing patients with benign metastasizing leiomyoma, it is very important to have a systematic description of such cases, since it may give an insight into the pathophysiological mechanisms and characteristics of this disease. Each clinical observation has a significant scientific value and makes it possible to obtain the information for developing the optimal treatment approaches and evaluating prognostic criteria.
Authors’ contributions: Kotiv Kh.B. – developing the design and concept of the study, critical review of the article for important intellectual content; Khmelevskaia E.M., Nyuganen A.O., Okonechnikova D.V. – developing the design of the study, preparing the draft of the manuscript; Berlev I.V. – critical review of the article for important intellectual content.
Conflicts of interest: The authors declare no possible conflicts of interest.
Funding: The study was conducted without sponsorship.
Patient Consent for Publication: The patient provided informed consent for the publication of their data and associated images.
For citation: Kotiv Kh.B., Khmelevskaia E.M., Nyuganen A.O., Okonechnikova D.V.,
Berlev I.V. Bilateral lung lesion caused by benign metastasizing uterine myoma.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025; (11): 195-200 (in Russian)
https://dx.doi.org/10.18565/aig.2025.53
Keywords
uterine myoma
benign metastasizing leiomyoma
lung metastases
References
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Received 28.02.2025
Accepted 17.06.2025
About the Authors
Khristina B. Kotiv, PhD, Researcher at the Department of Oncogynecology, N.N. Petrov NMRC of Oncology, Ministry of Health of Russia, 174644, Russia, St. Petersburg, Pesochny, Leningradskaya str., 68; Teaching Assistant at the Department of Obstetrics and Gynecology, I.I. Mechnikov NWSMU, Ministry of Health of Russia,191015, Russia, St. Petersburg, Kirochnaya str., 41, kotiv.onc@gmail.com, SPIN-code: 3049-8250, Scopus AuthorID: 57193895371, https://orcid.org/0000-0002-0486-2404
Ekaterina M. Khmelevskaia, student at the Faculty of General Medicine, I.I. Mechnikov NWSMU, Ministry of Health of Russia,
191015, Russia, St. Petersburg, Kirochnaya str., 41, khmelkate12@gmail.com, SPIN-code: 926-939, https://orcid.org/0009-0003-6928-3977
Anna O. Nyuganen, MD, Researcher at the Department of Pathomorphology, N.N. Petrov NMRC of Oncology, Ministry of Health of Russia, 174644, Russia, St. Petersburg, Pesochny, Leningradskaya str., 68, annanyuganen@gmail.com, SPIN-code: 2357-6059, https://orcid.org/0000-0003-2685-5093
Daria V. Okonechnikova, MD, doctor at the Radiology Department, N.N. Petrov NMRC of Oncology, Ministry of Health of Russia, 174644, Russia, St. Petersburg, Pesochny, Leningradskaya str., 68, okonechnikovad@gmail.com, SPIN-code: 2804-7854, https://orcid.org/0000-0001-9364-9332
Igor V. Berlev, Dr. Med. Sci., Head of the Department of Oncogynecology, N.N. Petrov NMRC of Oncology, Ministry of Health of Russia, 174644, Russia, St. Petersburg, Pesochny, Leningradskaya str., 68; Head of the Department of Obstetrics and Gynecology, I. I. Mechnikov NWSMU, Ministry of Health of Russia, 191015, Russia,
St. Petersburg, Kirochnaya str., 41, i.berliv@gmail.com, SPIN-code: 4169-6011, AuthorID: 668976, Scopus AuthorID: 6603322008, https://orcid.org/0000-0001-6937-2740
Corresponding author: Khristina B. Kotiv, kotiv.onc@gmail.com
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