Relationship between hypothyroidism and hyperprolactinemia

Shormanova L.Zh., Gabdiliashimova Z.T., Khamidullina Z.G., Akhmediyanova G.U.

Astana Medical University, Nur-Sultan, Kazakhstan
Thyroid diseases and hyperprolactinemia are now one of the most urgent problems that are of great medical and social significance. The literature describes concurrent primary hypothyroidism and hyperprolactinemia as Van Wyk-Ross-Hennes syndrome. The authors have analyzed the data available in the literature on hypothyroidism and hyperprolactinemia, in particular, their relationship to each other. The paper provides evidence supporting the relationship between hypothyroidism and elevated prolactin levels. Attention is focused on the presence of a causal relationship between hypothyroidism and the development of hyperprolactinemia. The paper includes publications available in the PubMed, Web of Science, Google Scholar, and eLIBRARY.RU databases by keywords.
Conclusion: This literature review indicates a close relationship between the levels of thyroid hormones and prolactin. However, a number of authors point to that hypothyroidism triggers higher prolactin levels, while other authors believe that hyperprolactinemia implies an increase in thyroid hormone levels. The above data indicate a long-term experience in studying this relationship and the lack of a consensus of opinion, which enables us to conclude that this issue is still open.




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Received 31.08.2022

Accepted 18.11.2022

About the Authors

Lyailya Zh. Shormanova, Doctoral Candidate, PhD; First-Year; Astana Medical University, Nur-Sultan, Kazakhstan, +77020007706,,, 49a, Beibitshilik St., Nur-Sultan (Astana) 010000, Republic of Kazakhstan.
Zarema T. Gabdiliashimova, MD; Associate Professor, Obstetrics and Gynecology Department One, Astana Medical University, Nur-Sultan, Kazakhstan,, 49a, Beibitshilik St., Nur-Sultan (Astana) 010000, Republic of Kazakhstan.
Gainyl U. Akhmediyanova, Cand. Med. Sci., Professor, Obstetrics and Gynecology Department One, Astana Medical University, Nur-Sultan, Kazakhstan,, 49a, Beibitshilik St., Nur-Sultan (Astana) 010000, Republic of Kazakhstan.
Zaituna G. Khamidullina, Cand. Med. Sci., PhD; Head, Obstetrics and Gynecology Department One, Astana Medical University, Nur-Sultan, Kazakhstan,, 49a, Beibitshilik St., Nur-Sultan (Astana) 010000, Republic of Kazakhstan.
Corresponding author: Lyailya Zh. Shormanova,

Authors’ contributions: All the authors have equally participated in writing this article. Shormanova L.Zh., Gabdiliashimova Z.T., Khamidullina Z.G., Akhmediyanova G.U. – material collection and processing; writing the text; editing.
Conflicts of interest: The authors declare that there are no conflicts of interest.
Funding: The investigation has been conducted without attracting funding from third parties and medical representatives.
For citation: Shormanova L.Zh., Gabdiliashimova Z.T., Khamidullina Z.G., Akhmediyanova G.U. Relationship between hypothyroidism and hyperprolactinemia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 12: 46-49 (in Russian)

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