Age and body mass index as factors of female infertility and negative results of assisted reproductive technologies

DOI

https://dx.doi.org/10.18565/aig.2021.2.21-26

Ruziguli A., Rukhliada N.N.
Department of Obstetrics and Gynecology, Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg, Russia

To improve the effectiveness of assisted reproductive technologies is a key problem in modern medicine. Therapeutic approaches to reducing the likelihood of not getting pregnant are inevitably associated with infertility-related risk factors. Women with good reproductive health mostly become mothers naturally, apart from being influenced by the male factor or resorting to medical decisions through personal reasons. Among the standard risk factors that lead to a decrease in the effectiveness of assisted reproductive technologies, there are obesity and late reproductive age. The paper considers the mechanisms for the negative effects of these features of the anamnesis and the ways to reduce/overcome their harmful effects on pregnancy. An analysis of information sources has identified the possibilities of increasing the effectiveness of the onset and preservation of induced pregnancy in the presence of the above risk factors. It has been found that it is necessary to organize a comprehensive preparation of a woman's health before reproductive intervention in order to normalize weight and the hormone background. Only a change in lifestyle and consolidation of new behavior can significantly reduce the negative impact of obesity on a woman's reproductive health. Treatment should be performed taking into account concomitant diseases, in particular diabetes mellitus, polycystic ovary syndrome, etc. The successes of pharmacological treatment for obesity in reducing the level of influence of infertility and in increasing the effectiveness of assisted reproductive technologies are analyzed separately.
Conclusion. It has been found that there are very few drugs that can be used to correct weight during pregnancy when planning due to side effects. Before planning a pregnancy at late reproductive age, there is a need for exhaustive analysis of the female reproductive system, including an evaluation of the ability to ovulate and the state of the endometrium. Exogenous hormonal background correction must be done. The negative effect of obesity or late reproductive age depends on many individual characteristics of the patient's history. Therefore, whether there is a prevalence of the influence of one or another factor in their combination remains unresolved and causes discussion.

obesity

body mass index

late reproductive age

assisted reproductive technologies

Full text (in Russian)

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Received 30.10.2020

Accepted 16.11.2020

Abuduwaili Ruziguli, postgraduate student, Department of Obstetrics and Gynecology, St. Petersburg State Pediatric Medical University, Ministry of Health of Russia.
Tel.: +7(911)817-55-35. E-mail: 2568141218@mail.ru. 194100, Russia, St. Petersburg, Litovskaya str., 2.
Nikolai N. Rukhliada, Dr. Med. Sci., Head of the Department of Obstetrics and Gynecology, St. Petersburg State Pediatric Medical University, Ministry of Health of Russia. Tel.: +7(911)817-55-35. E-mail: 2568141218@mail.ru. 194100, Russia, St. Petersburg, Litovskaya str., 2.

For citation: Ruziguli A., Rukhliada N.N. Age and body mass index as factors of female infertility and negative results of assisted reproductive technologies.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 2: 21-26 (in Russian)
https://dx.doi.org/10.18565/aig.2021.2.21-26

Age and body mass index as factors of female infertility and negative results of assisted reproductive technologies

Ruziguli A., Rukhliada N.N.

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