Possibilities for increasing the effectiveness of assisted reproductive technology programs using cumulus-oocyte complex-induced sperm selection
The data available in modern scientific literature on the role of cumulus cells and sperm selection using cumulus-oocyte complexes to improve the effectiveness of assisted reproductive technology (ART) programs were systematically analyzed. The review includes data from foreign articles found in the PubMed (https://pubmed.ncbi.nlm.nih.gov), which have been published over the past 10 years.Chistyakova A.V., Makarova N.P., Lobanova N.N., Smolnikova V.Yu.
The cumulus cells surrounding the oocyte during natural fertilization serve as a selective barrier that allows the selection of spermatozoa with a high potential for penetration through the oocyte membranes (zona pellucida, membrane) and with the subsequent activation of a female germ cell. The review presents modern techniques that can simulate natural fertilization in infertility treatment programs using ART methods. It describes the impact of sperm selection technology using the cumulus cells on the fertility rates of male gametes and the results of in vitro fertilization programs. The review notes the contradictory results of the effectiveness of this selection on the outcomes of ART programs, which, according to some authors, depend on the manipulations and methods for preparing plates for sperm selection and on the quality of the cumulus cells derived from the spouse.
Conclusion: The data accumulated to date confirm the feasibility and prospects of studying the effectiveness of various modern sperm selection techniques. Further studies are needed to assess the predictive value of the interaction of spermatozoa with cumulus cells on the effectiveness of ART programs and pregnancy outcomes. Further studies are needed to assess the predictive value of the sperm-cumulus cell interaction on the effectiveness of ART programs and pregnancy outcomes.
Keywords
assisted reproductive technologies
infertility
intracytoplasmic sperm injection (ICSI)
in vitro fertilization (IVF)
implantation
male infertility
spermatozoon
cumulus-oocyte complex
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Received 24.03.2022
Accepted 29.04.2022
About the Authors
Alina V. Chistyakova, PhD Student, Department of IVF named after Professor B.V. Leonov, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, alinadubinina_07@mail.ru, 117997, Russia, Moscow, Academician Oparin str., 4.Natalya P. Makarova, Dr. Bio. Sci., Leading Researcher, Department of IVF named after Professor B.V. Leonov, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, np_makarova@oparina4.ru, 117997, Russia, Moscow, Academician Oparin str., 4.
Natalia N., Lobanova, Junior Researcher, Department of IVF named after Professor B.V. Leonov, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, n_lobanova@oparina4.ru, 117997, Russia, Moscow, Academician Oparin str., 4.
Veronika Yu. Smolnikova, Dr. Med. Sci., Associate Professor, Leading Researcher, Department of IVF named after Professor B.V. Leonov, Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, v_smolnikova@oparina4.ru,
117997, Russia, Moscow, Academician Oparin str., 4.
Authors' contributions: Chistyakova A.V. – collection and analysis of literature data, processing of the starting material and writing the article; Makarova N.P. – collection and analysis of literature data, editing the manuscript of the article; Smolnikova V.Yu. – editing the manuscript, critical analysis.
Conflicts of interest: The authors declare that there are no possible conflicts of interest.
Funding: The investigation was conducted without attracting additional funding from third parties.
For citation: Chistyakova A.V., Makarova N.P., Lobanova N.N., Smolnikova V.Yu.
Possibilities for increasing the effectiveness of assisted reproductive technology programs
using cumulus-oocyte complex-induced sperm selection.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2022; 5: 30-34 (in Russian)
https://dx.doi.org/10.18565/aig.2022.5.30-34
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