Possibilities of a combined approach to treating endometriosis-associated infertility

Artymuk N.V., Danilova L.N., Tachkova O.A.

1) Kemerovo State Medical University, Kemerovo, Russia; 2) M.A. Podgorbunsky Kemerovo Regional Clinical Hospital of Emergency Medical Care, Kemerovo, Russia
Objective. To assess the clinical and socio-hygienic characteristics of patients with endometriosis-associated infertility and to comparatively evaluate the effectiveness and compliance of a combined approach to its treatment using gestagen (dienogest) and a gonadotropin-releasing hormone (GnRH) agonist.
Subjects and methods. The investigation enrolled 150 patients with histologically confirmed endometriosis-associated infertility, by excluding other causes of infertility. Study design: a randomized, open-label, monocentric trial. Group 1 consisted of 75 women who, after surgical treatment for endometriosis (ablation and/or excision), took the GnRH agonist buserelin or diphereline at a dose of 3.75 mg once every 28 days for 3 months intramuscularly (subcutaneously). Group 2 included 75 women who were postoperatively prescribed gestagen (dienogest) at a dose of 2 mg daily for 6 months continuously.
Results. The combined treatment of endometriosis-associated infertility via surgery, followed by the administration of both the GnRH agonist and dienogest, was highly effective in reducing the clinical manifestations of endometriosis, such as pelvic pains, dysmenorrhea, dyspareunia, and bleeding. The spontaneous pregnancy rate in both groups was similar (53.3% and 54.7%, respectively; p = 0.870). The patients receiving dienogest versus those taking the GnRH agonist were recorded to have a significantly lower frequency of adverse effects (16% and 92%, respectively), a tendency toward lower rates of undeveloped pregnancy (9.3% and 17.3%). and a higher rate of live births (90.7% and 82.7%; p = 0.489).
Conclusion. The use of gestagen in the combined therapy of patients with endometriosis-associated infertility and pelvic pain has advantages over that of the GnRH agonist due to their similar efficacy and the lower frequency of adverse effects.


endometriosis-associated infertility
gonadotropin-releasing hormone agonists
combined treatment for endometriosis


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Received 01.10.2019

Accepted 04.10.2019

About the Authors

Natalya V. Artymuk, MD, professor, head of the Department of Obstetrics and Gynecology named after Professor G.A. Ushakova of the Kemerovo State Medical University, chief freelance specialist of the Russian Ministry of Health in Obstetrics and Gynecology in the Siberian Federal District, president of the Kemerovo regional public organization “Association of Obstetricians and Gynecologists”, member of the Presidium of the Board of the Russian Society of Obstetricians and Gynecologists, 22a,
tel.: + 7 (3843) 734856, artymuk@gmail.com ORCID: 0000-0001-7014-6492
650056, Kemerovo, Voroshilov street, d.22a.
Larisa N. Danilova, Head of the Gynecological Department of the Kemerovo Regional Clinical Emergency Hospital named after M.A. Podgorbunsky. Phone: + 7 (3842) 392222, e-mail: lar.danilova@mail.ru, ORCID: 0000-0002-1272-401X
650000, Kemerovo, Ostrovsky street, 22.
Olga A. Tachkova, candidate of medical sciences, associate professor of the Department of Hospital Therapy and Clinical Pharmacology of Kemerovo State Medical University. Phone: +7 (3843) 734856 E-mail: ol.an.t@yandex.ru, ORCID 0000-0002-6537-3460
650056, Kemerovo, Voroshilov street, d.22a.

For citation: Artymuk N.V., Danilova L.N., Tachkova O.A. Possibilities of a combined approach to treating endometriosis-associated infertility.
Akusherstvo i Ginekologiya / Obstetrics and gynecology. 2019; 10: 148-56. (In Russian).

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