Impact of influenza vaccination on the course of pregnancy and on fetal and neonatal development
Objective. To carry out a systematic analysis of the data available in the current literature on the impact of influenza vaccination on the course of pregnancy and on fetal and neonatal development. To comparatively analyze the effects of subunit non-adjuvanted and subunit immunoadjuvant influenza vaccines on increases in the titer of antibodies against influenza virus strains in mother-neonate pairs with regard to the trimester of pregnancy.Khromova E.A., Akhmatova E.A., Kostinova A.M., Cherdantsev A.P., Savisko A.A., Akhmatova N.K.
Material and methods. The review includes the current and topical materials of foreign and Russian investigators from the MEDLINE database in the past 10 years.
Results. Inactivated subunit influenza vaccines administered in the second and third trimesters of pregnancy have been found to have no impact on the course of pregnancy, the development of a fetus and a baby within first 6 months of life and to result in the synthesis of antibodies that can protect not only the vaccinated women, but also their infants during the first 3 to 5 months of life.
Conclusion. Influenza vaccination with inactivated subunit vaccines in the second and third trimesters of pregnancy is a safe and effective method to protect both pregnant women and their babies against influenza.
Keywords
subunit non-adjuvanted and subunit immunoadjuvant influenza vaccines
pregnancy
fetus
neonates
References
1. Bektimirov T.A. Vaccine prophylaxis of influenza. Lechaschiy vrach. 2005; 9: 44-6. (in Russian)
2. Tarbayeva D.A., Kostinov M. P., Zagorodnyaya E.D., Iozefson S.A., Cherdantsev A.P. The obstetric and perinatal outcomes of acute respiratory infection-complicated pregnancy in the second trimester of pregnancy. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2012; (2): 67-71. (in Russian)
3. Tarbaeva D.A., Kostinov M.P., Iozefson S.A., Zagorodnyaya E.D. Clinical course and outcomes of influenza A (H1N1) 2009 in pregnant women. Zhurnal mikrobiologii, epidemiologii i immunobiologii. 2011; 4: 71-6. (in Russian)
4. Kuzmin V.N. The problem of the H1N1 flu virus and the features of the disease in women during pregnancy. Lechaschiy vrach. 2010; 1: 66-8. (in Russian)
5. Kostinov M.P., Cherdantsev A.P., Semenova S.S., Tarbaeva D.A., Savisko A.A., Serova O.F., Iozefson S.A., Ahmatova N.K., Kostinova T.A., Praulova D.A. Obstetric and perinatal outcomes after vaccination against influenza or respiratory infection. Ginekologiya. 2015; 17(4): 43-6. (in Russian)
6. Belokrinitskaya T.E., Tarbaeva D.A., Trubitsyina A.Yu., Chartorizhskaya N.N., Shapovalov K.G. Features of the swine flu in dead pregnant women and in cases that almost ended in a fatal outcome. Lechaschiy vrach. 2013; 3: 31-7. (in Russian)
7. Siston A.M., Rasmussen S.A., Honein M.A., Fry A.M., Seib K., Callaghan W.M. et al. Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States. JAMA. 2010; 303(15): 1517-25.
8. Ortiz J.R., Englund J.A., Neuzil K.M. Influenza vaccine for pregnant women in resource-constrained countries: A review of the evidence to inform policy decisions. Vaccine. 2011; 29(27): 4439-52.
9. Anzic Influenza Investigators. Australian Maternity Outcomes Surveillance System. Critical illness due to 2009 A/H1N1 influenza in pregnant and posrpartum women: population based cohort study. BMJ. 2010; 340: 1279-84. doi: https://doi.org/10.1136/bmj.c1279 (Published 19 March 2010)
10. Pebody R.G., McLean E., Zhao H., Cleary P., Bracebridge S., Foster K. et al. Pandemic influenza A (H1N1) 2009 and mortally in the United Kindom: risk factors for dears, April 2009 to March 2010. Euro Surveillance. 2010; 15(20): 1333-40.
11. Glezen W.P., Taber H.L., Frank L.A. Gruber W.C., Piedra P.A. Influenza virus infection in infants. Pediatr. Infect. Dis. J. 1997; 16(11): 1065-8.
12. Naleway A.L., Smith W.J., Mullooly J.P. Delivering influenza vaccine to pregnant women. Epidemiol. Rev. 2006; 28(1): 47-54.
13. On the approval of the national calendar of preventive vaccinations and the calendar of preventive vaccinations for epidemiological indications. Order of the Ministry of Health of the Russian Federation No. 125 n of 21.03.2014. (in Russian)
14. Cherdantsev A.P., Kostinov M.P., Kuselman A.I. Vaccine prophylaxis of influenza in pregnant women. A guide for doctors. Moscow; 2013. 35p. (in Russian)
15. Kostinov M.P., Cherdantsev A.P. Health status of infants born to vaccinated against influenza pregnant women. Pediatriya. Zhurnal im. G.N. Speranskogo. 2016; 95(1): 67-71. (in Russian)
16. Steinhoff M.C., Omer S.B., Roy E., Arifeen S.E., Raqib R., Altaye M. et al. Influenza immunization in pregnancy – antibody responses in mothers and infants. N. Engl. J. Med. 2010; 362(17): 1644-6.
17. Kostinov M.P., Cherdantsev A.P., Praulova D.A., Kostinova A.M. Vaccination against influenza is a safe way to protect pregnant women and newborns from the consequences of infection. Rossiyskiy vestnik akushera-ginekologa. 2015; 15(5): 69-74. (in Russian)
18. Note for guidance on harmonization of requirements for influenza vaccines (CPMP/BWP/214/96). Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_ guideline/2009/09/WC500003945.pdf
19. Kostinov M.P., Cherdantsev A.P., Shmitko A.D., Pakhomov D.V., Demina E.O. Duration of preservation of antibodies to the flu virus in the mother-child pairs during the vaccination of women depending on the trimester of pregnancy. Int. J. Biomed. 2015; 5(4): 179-83. doi: 10.21103/Article5(4).
20. Kostinov M.P., Cherdantsev A.P., Pakhomov D.V. Anti-influenza antibody level in Mother-infant pairs depending on trimester of vaccination of pregnant women using immunoadjuvant vaccine. J. Vaccines Vaccin. 2015; 6: 297. doi: http://dx.doi.org/10.4172/2157-7560.1000297.
21. Костинов М.П., Черданцев А.П., Сависько А.А. и др. Безопасность и иммуногенность вакцин против гриппа у беременных. М.: ГУ «НИИВС им. И.И. Мечникова» РАМН; 2011. [Kostinov M.P., Cherdantsev A.P., Savisko A.A. et al. Safety and immunogenicity of influenza vaccines in pregnant women. Moscow: GU «NIIVS im. I.I. Mechnikova» RAMN; 2011.
22. Cherdantsev A.P. Study of the clinical safety of vaccination against influenza in pregnant women. Meditsinskiy almanah. 2011; 4: 120-2. (in Russian)
23. Kostinov M.P., Cherdantsev A.P., Savisko A.A., Tarbaeva D.A., Soloveva I.L. True and false reactions to the introduction of a vaccine against influenza in pregnant women. Voprosyi ginekologii, akusherstva i perinatologii. 2011; 10(6): 44-9. (in Russian)
24. Steinhoff M.C., Omer S.B., Roy E., El Arifeen S., Raqib R., Dodd C. et al. Neonatal outcomes after influenza immunization during pregnancy: a randomized controlled trial. Can. Med. Assoc. J. 2012; 184(6): 645-53.
25. Kostinov M.P., Cherdantsev A.P. The clinical and immunological safety of inactivated immunologic adjuvant influenza subunit vaccine for pregnant women. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2016; (2): 64-69. (in Russian) http://dx.doi.org/10.18565/aig.2016.2.64-69
26. Jamieson D.J., Honein M.A., Rasmussen S.A., Williams J.L., Swerdlow D.L., Biggerstaff M.S. et al. H1N1influenza virus infection during pregnancy in the USA. Lancet. 2009; 374(9688): 451-8.
27. Makarova O.V., Aleshkina V.A., Savchenko T.N. Infections in obstetrics and gynecology. Moscow: MEDpress-inform; 2007. (in Russian)
Received 20.09.2016
Accepted 11.11.2016
About the Authors
Khromova Ekaterina Aleksandrovna, junior researcher, post-graduate student, I.I. Mechnikov Research Institute of Vaccines and Sera.105064, Russia, Moscow, Maly Kazenniy per. 5. E-mail: kate.khromova@mail.ru
Akhmatova Elina Altafovna, a student of the medical faculty of the Higher School of Economics, I.M. Sechenov First Moscow State Medical University,
Ministry of Health of Russia. 119992, Russia, Moscow, Malaya Trubetskaya str. 8, bld. 2. E-mail: ela.150@yandex.ru
Kostinova Aristika Mikhailovna, resident, Institute of Immunology, Federal Biomedical Agency of Russia.
115478, Russia, Moscow, Kashirskoye sh. 24. E-mail: aristica_kostino@mail.ru
Cherdantsev Alexander Petrovich, MD, Professor of the Department of Pediatrics, Ulyanovsk State University.
432017, Russia, Ulyanovsk, Lva Tolstogo str. 42. E-mail: a_cherdantsev@rambler.ru
Savisko Anna Alekseevna, Candidate of Medical Science, Associate Professor of the Department of Outpatient and Emergency Pediatrics, Rostov State Medical University, Ministry of Health of Russia. 344022, Russia, Rostov-on-Don, Suvorova str. 119. E-mail: Annsav@mail.ru
Akhmatova Nelli Kimovna, MD, Head of the Laboratory of Immune Regulation Mechanisms, I.I. Mechnikov Research Institute of Vaccines and Sera.
105064, Russia, Moscow, Maly Kazenniy per. 5. E-mail: anelly@mail.ru
For citations: Khromova E.A., Akhmatova E.A., Kostinova A.M.,
Cherdantsev A.P., Savisko A.A., Akhmatova N.K. Impact of influenza vaccination
on the course of pregnancy and on fetal and neonatal development.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (7): 12-7. (in Russian)
http://dx.doi.org/10.18565/aig.2017.7.12-7
Similar Articles
