Vitamins and trace elements in the prevention of minor malformations
Objective. To analyze the relationship between the provision of vitamins and trace elements during pregnancy and the so-called minor malformationsGromova O.A., Torshin I.Yu., Tetruashvili N.K.
Material and methods. The review presents the results of a systematic analysis of foreign and Russian studies of the associations between trace element deficiencies and the pathogenesis, incidence, and severity of fetal congenital malformations (CMFs).
Results. Trace element deficiencies during pregnancy are associated with obvious CMFs (syndactyly and other limb defects, impaired dentition, hernias, etc.) and CMF that manifested itself in early childhood (congenital heart defects, defects of the ureter, gallbladder, etc.). An analysis has shown that folates fall far short of being not the only trace element that is needed to prevent malformations, including the so-called minor ones (defects of the limbs, teeth, etc.). For example, zinc that regulates the activity of more than 1200 zinc-dependent proteins, as well as vitamin A and vitamin PP have no less an important role to play in the prevention of defects of dentition, fingers, auricles, lungs, diaphragm, and gallbladder. Deficiencies of zinc, vitamins A, E, D, and C and any of the B vitamins (including folates, pyridoxine and cyanocobalamin) stimulate the development of both minor and major malformations.
Conclusion. The data from basic researches and evidence-based medicine indicate that it is necessary to mandatorily use vitamin-mineral complexes, including all the above trace elements, for the effective primary prevention of any fetal malformations.
Keywords
minor congenital malformations
trace elements
elevit pronatal
Supplementary Materials
- Table. Known and congenital malformations associated with Zn -dependent signaling pathways functioning disorders
- Fig. 1. Different e VPR, which leads n arushenie activity of zinc-dependent protein Shh
- Fig. 2. The spatial structure of ubiquitin ligase (for example Ub-ligase CBL-type E3 ubiquitin ligase), the lack of activity is associated with's facial dysmorphism and retardation (Noonan syndrome, OMIM 613563). Showed zinc atom in the domain part of the "zinc finger» (PDB file 4a4b)
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Received 16.06.2017
Accepted 23.06.2017
About the Authors
Gromova Olga Alekseevna, MD, professor of Ivanovo State Medical Academy. 153000, Russia, Ivanovo, Sheremetiev pr. 8. Tel.: +74932301766.E-mail: unesco.gromova@gmail.com
Torshin Ivan Yurievich, candidate of physic-mathematical sciences, associate professor, Moscow Institute of Physics and Technology.
141700, Russia, Moscow Region, Dolgoprudny, Institutsky pereulok, 9. Tel.: +74991352489, +74932416525
Tetruashvili Nana Kartlosovna, Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy, Research Center for Obstetrics,
Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381183. E-mail: tetrauly@mail.ru
For citations: Gromova O.A., Torshin I.Yu., Tetruashvili N.K.
Vitamins and trace elements in the prevention of minor malformations.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (8): 10-20. (in Russian)
http://dx.doi.org/10.18565/aig.2017.8.10-20
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