Vitamin K-dependent protein periostin as a new marker for the quality of oocytes and embryos, and the effectiveness of assisted reproductive technologies program
Objective. To assess the role of the vitamin K-dependent protein periostin as a marker for the quality of oocytes and embryos and the outcome of an IVF/ICSI program.Khechumyan L.R., Kalinina E.A., Burmenskaya O.V., Donnikov A.E., Kulakova E.V.
Subjects and methods. The investigation enrolled 100 women who were eligible for inclusion. In accordance with the results of infertility treatment, the investigators formed two study groups: 1) 28 patients with a successful treatment outcome, of whom two patients were found to have a biochemical pregnancy; 2) 72 patients with a negative treatment result. All the women underwent determination of mean follicular fluid level of periostin and its mRNA expression in the epithelial cells of the cervical canal.
Results. A correlation was shown between the follicular fluid level of periostin and the quality of oocytes and embryos. The group of women who had immature oocytes showed an association of the follicular fluid level of periostin and its mRNA expression in the epithelial cells of the cervical canal with incipient pregnancy (28%) after an IVF/ICSI program.
Conclusion. The high follicular fluid level of periostin in the patients who had immature oocytes among those retrieved using the IVF/ICSI program is a predictive criterion of success of the program, which may reflect a relationship between the level of periostin and the degree of oocyte maturity.
Keywords
assisted reproductive technology
infertility
periostin
POSTN
in vitro fertilization
mRNA expression
embryo implantation
Supplementary Materials
- Fig . 1. The average level of periostine in the follicular fluid in patients depending on the presence of immature oocytes, the sex of the scientists in the stimulated cycle
- Fig . 2. mRNA expression level periostina cervical epithelial cells in patients having immature oocytes obtained in e stimulated cycle
- Table. Characteristics of patients in the study groups
References
1. Корсак В.С., Смирнова А.А., Шурыгина О.В. ВРТ в России. Отчет за 2013 год. Регистр ВРТ. СПб.: Российская Ассоциация Репродукции Человека; 2015: 26-9. [Korsak V.S., Smirnova A.A., Shurygina O.V. ART in Russia. The report for 2013. Register of ART. St. Petersburg: Russian Association of Human Reproduction; 2015: 26-9. (in Russian)]
2. Kupka M.S., Ferraretti A.P., de Mouzon J., Erb K., D’Hooghe T., Castilla J.A. et al. European IVF-Monitoring Consortium, for the European Society of Human Reproduction and Embryology. Assisted reproductive technology in Europe 2010: results generated from European registers by ESHRE Hum. Reprod. 2014; 29(10): 2099-113.
3. Martins W.P., Rocha I.A., Ferriani R.A., Nastri C.O. Assisted hatching of human embryos : a systematic review and meta-analysis of randomized controlled trials. Hum. Reprod. Update. 2011; 17(4): 438-53. doi: 10.1093/humupd/dmr012.
4. Gunby J., Daya S. Assisted reproductive technologies (ART) in Canada: 2002 results from the Canadian ART Register. Fertil. Steril. 2006; 86(5): 1356-64. doi: 10.1016/j.fertnstert.2006.04.030.
5. Кузьмичев Л., Смольникова В., Калинина Е., Дюжева Е. Принципы комплексной оценки и подготовки эндометрия у пациенток программ вспомогательных репродуктивных технологий. Акушерство и гинекология. 2010; 5: 32-6. [Kuzmichev L.N., Smolnikova V.Yu., Kalinina Ye.A., Dyuzheva Ye.V. The principles of complex evaluation and preparation of the endometrium in patients of assisted reproductive technology programs. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2010; (5): 32-6. (in Russian)]
6. Morelli M., Misaggib R., Di Cello A., Zuccalà V., Costanzo F., Zullo F., Quaresimain B. Tissue expression and serum levels of periostin during pregnancy: a new biomarker of embryo-endometrial cross talk at implantation. Eur. J. Obstet. Gynecol. Reprod. Biol. 2014; 175: 140-4.
7. Калинина Е.А., Донников А.Е., Владимирова И.В. Молекулярно- генетические предикторы овариального ответа, качества ооцитов и эмбрионов в программах вспомогательных репродуктивных технологий. Акушерство и гинекология. 2015; 3: 21-5. [Kalinina E.A., Donnikov A.E., Vladimirova I.V. Molecular genetic predictors of ovarian response, oocyte and embryo qualities in assisted reproductive technology programs. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2015; (3): 21-5. (in Russian)]
8. Bromer J.G., Seli E. Assessment of embryo viability in assisted reproductive technology shortcomings of current approaches and the emerging role of metabolomics. Curr. Opin. Obstet. Gynecol. 2008; 20(3): 234-41.
9. Di Cello A., Rania E., Di Sanzo M., Alviggi E., Rienzi L., Morelli M., Zullo F., Costanzo F. Periostin a new non-invasive parameter in addition to the morphologic criteria for evaluating oocyte/blastocyst quality and its impact on endometrial receptivity. In: Abstract book of the 31st ESHRE Annual Meeting, Lisbon, Portugal, 14-17 June 2015. Hum Reprod. 2015; 30(Suppl. 1): i1-i501. doi: 10.1093/humrep/30.Supplement_1.1.
10. Coutu D.L., Wu J.H., Monette A., Rivard G.E., Blostein M.D., Galipeau J. Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. J. Biol. Chem. 2008; 283(26): 17991-8001.
11. Achache H., Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum. Reprod. Update. 2006; 12(6): 731-46.
12. Acosta A.A., Elberger L., Borghi M., Calamera J.C., Chemes H., Doncel G.F. et al. Endometrial dating and determination of the window of implantation in healthy fertile women. Fertil. Steril. 2000; 73(4): 788-98.
13. Ng Y.H., Zhu H., Leung P.C. Twist modulates human trophoblastic cell invasion via regulation of N-cadherin. Endocrinology. 2012; 153(2): 925-36.
14. Hiroi H., Momoeda M., Nakazawa F., Koizumi M., Tsutsumi R., Hosokawa Y. et al. Expression and regulation of periostin/OSF-2 gene in rat uterus and human endometrium. Endocr. J. 2008; 55(1): 183-9.
Received 13.10.2017
Accepted 27.10.2017
About the Authors
Khechumyan Lusine Robertovna, graduate student of department of assisted reproductive technology in treating sterility, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954382501. E-mail: khechumyan_l@mail.ru
Kalinina Elena Anatolievna, MD, Associate Professor, The chief of department of assisted reproductive technology in treating sterility, National Medical Research
Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: e_kalinina@oparina4.ru
Burmenskaya Olga V., PhD, DSc, Senior Researcher of Molecular-Genetics Department, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954382292. E-mail: o_bourmenskaya@oparina4.ru
Donnikov Andrew Evgenievich, PhD, Senior Researcher of molecul-genetical laboratory, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: a_donnikov@oparina4.ru
Kulakova Elena Vladimirovna, PhD, Senior Researcher of department of assisted reproductive technology in treating sterility, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: evkulakova@mail.ru
For citations: Khechumyan L.R., Kalinina E.A., Burmenskaya O.V., Donnikov A.E., Kulakova E.V. Vitamin K-dependent protein periostin as a new marker for the quality of oocytes and embryos, and the effectiveness of assisted reproductive technologies program. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (4): 72-6. (in Russian)
https://dx.doi.org/10.18565/aig.2018.4.72-76
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