Vitamin K-dependent protein periostin as a new marker for the quality of oocytes and embryos, and the effectiveness of assisted reproductive technologies program

Khechumyan L.R., Kalinina E.A., Burmenskaya O.V., Donnikov A.E., Kulakova E.V.

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia, Moscow 117997, Ac. Oparina str. 4, Russia
Objective. To assess the role of the vitamin K-dependent protein periostin as a marker for the quality of oocytes and embryos and the outcome of an IVF/ICSI program.
Subjects and methods. The investigation enrolled 100 women who were eligible for inclusion. In accordance with the results of infertility treatment, the investigators formed two study groups: 1) 28 patients with a successful treatment outcome, of whom two patients were found to have a biochemical pregnancy; 2) 72 patients with a negative treatment result. All the women underwent determination of mean follicular fluid level of periostin and its mRNA expression in the epithelial cells of the cervical canal.
Results. A correlation was shown between the follicular fluid level of periostin and the quality of oocytes and embryos. The group of women who had immature oocytes showed an association of the follicular fluid level of periostin and its mRNA expression in the epithelial cells of the cervical canal with incipient pregnancy (28%) after an IVF/ICSI program.
Conclusion. The high follicular fluid level of periostin in the patients who had immature oocytes among those retrieved using the IVF/ICSI program is a predictive criterion of success of the program, which may reflect a relationship between the level of periostin and the degree of oocyte maturity.

Keywords

assisted reproductive technology
infertility
periostin
POSTN
in vitro fertilization
mRNA expression
embryo implantation

Supplementary Materials

  1. Fig . 1. The average level of periostine in the follicular fluid in patients depending on the presence of immature oocytes, the sex of the scientists in the stimulated cycle
  2. Fig . 2. mRNA expression level periostina cervical epithelial cells in patients having immature oocytes obtained in e stimulated cycle
  3. Table. Characteristics of patients in the study groups

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Received 13.10.2017

Accepted 27.10.2017

About the Authors

Khechumyan Lusine Robertovna, graduate student of department of assisted reproductive technology in treating sterility, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954382501. E-mail: khechumyan_l@mail.ru
Kalinina Elena Anatolievna, MD, Associate Professor, The chief of department of assisted reproductive technology in treating sterility, National Medical Research
Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: e_kalinina@oparina4.ru
Burmenskaya Olga V., PhD, DSc, Senior Researcher of Molecular-Genetics Department, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954382292. E-mail: o_bourmenskaya@oparina4.ru
Donnikov Andrew Evgenievich, PhD, Senior Researcher of molecul-genetical laboratory, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: a_donnikov@oparina4.ru
Kulakova Elena Vladimirovna, PhD, Senior Researcher of department of assisted reproductive technology in treating sterility, National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia.
117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74954381341. E-mail: evkulakova@mail.ru

For citations: Khechumyan L.R., Kalinina E.A., Burmenskaya O.V., Donnikov A.E., Kulakova E.V. Vitamin K-dependent protein periostin as a new marker for the quality of oocytes and embryos, and the effectiveness of assisted reproductive technologies program. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2018; (4): 72-6. (in Russian)
https://dx.doi.org/10.18565/aig.2018.4.72-76

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