Subclinical varicocele: criteria for diagnosis, a role in the development of male infertility, a modern approach to treatment

Akhvlediani N.D., Chernushenko A.S., Reva I.A., Pushkar D.Yu.

1) Department of Urology, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; 2) University Clinic “Kuskovo”, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Subclinical varicocele is characterized by the nonpalpable veins of the spermatic cord and the absence of visible scrotal changes at rest and during Valsalva maneuver. Pathologically dilated veins are identified using Doppler ultrasound. Correction of clinical varicocele in infertile males has been proven to improve spermogram parameters and to increase the chance of fertilization in most patients. However, surgical treatment for subclinical varicocele is controversial and remains a matter of debate. Thirty-four articles have been analyzed using the MEDLINE/PubMed database regarding the treatment of subclinical varicocele. The authors have compared information on the effects of subclinical varicocele on male fertility. They have evaluated the efficiency and feasibility of performing microsurgical correction of subclinical varicocele in infertile males.
Conclusion. Surgical treatment as microsurgical subinguinal ligation of the spermatic cord veins is indicated for the treatment of infertile patients with subclinical varicocele. In the cases that left clinical varicocele is concurrent with contralateral subclinical varicocele, surgical treatment should be performed on both sides.

Keywords

varicocele
subclinical varicocele
spermogram
infertility
microsurgery

References

  1. Lomboy J.R., Coward R.M. The varicocele: clinical presentation, evaluation, and surgical management. Semin. Intervent. Radiol. 2016; 33(3): 163-9. https://dx.doi.org/10.1055/s-0036-1586143.
  2. Brannigan R.E. Introduction: varicoceles: a contemporary perspective. Fertil. Steril. 2017; 108(3): 361-3. https://dx.doi.org/10.1016/j.fertnstert.2017.07.1161.
  3. Dubin J.M., Greer A.B., Kohn T.P., Masterson T.A., Ji L., Ramasamy R. Men with severe oligospermia appear to benefit from varicocele repair: a cost-effectiveness analysis of assisted reproductive technology. Urology. 2018; 111: 99-103. https://dx.doi.org/10.1016 /j.urology.2017.10.010.
  4. Kohn T.P., Kohn J.R., Pastuszak A.W. Varicocelectomy before assisted reproductive technology: are outcomes improved? Fertil. Steril. 2017; 108(3): 385-91. https://dx.doi.org/10.1016/j.fertnstert.2017.06.033.
  5. Kirby E.W., Wiener L.E., Rajanahally S., Crowell K., Coward R.M. Undergoing varicocele repair before assisted reproduction improves pregnancy rate and live birth rate in azoospermic and oligospermic men with a varicocele: a systematic review and meta-analysis. Fertil. Steril. 2016; 106(6): 1338-43. https://dx.doi.org/10.1016/j.fertnstert.2016.07.1093.
  6. Marsman J.W. Clinical versus subclinical varicocele: venographic findings and improvement of fertility after embolization. Radiology. 1985; 155(3): 635-8. https://dx.doi.org/10.1148/radiology.155.3.4001363.
  7. Practice Committee of the American Society for Reproductive Medicine; Society for Male Reproduction and Urology. Report on varicocele and infertility: a committee opinion. Fertil. Steril. 2014; 102(6): 1556-60. https://dx.doi.org/10.1016/j.fertnstert.2014.10.007.
  8. Dubin L., Amelar R.D. Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertil. Steril. 1970; 21(8): 606-9. https://dx.doi.org/10.1016/s0015-0282(16)37684-1.
  9. World Health Organization. WHO manual for the standardized investigation, diagnosis and management of the infertile male. Cambridge University Press; 2000. 102p. Available at: http: //www.who.int/reproductivehealth/publications/ infertility/0521774748/en/
  10. Yarborough M.A., Burns J.R., Keller F.S. Incidence and clinical significance of subclinical scrotal varicoceles. J. Urol. 1989; 141(6): 1372-4. https://dx.doi.org/10.1016/s0022-5347(17)41311-5.
  11. Dhabuwala C.B., Hamid S., Moghissi K.S. Clinical versus subclinical varicocele: improvement in fertility after varicocelectomy. Fertil. Steril. 1992; 57(4): 854-7. https://dx.doi.org/10,1016/s0015-0282 (16)54970-х.
  12. Yamamoto M., Hibi H., Hirata Y., Miyake K., Ishigaki T. Effect of varicocelectomy on sperm parameters and pregnancy rate in patients with subclinical varicocele: randomized prospective controlled study. J. Urol. 1996; 155(5): 1636-8.
  13. Jarow J.P., Ogle S.R., Eskew L.A. Seminal improvement following repair of ultrasound detected subclinical varicoceles. J. Urol. 1996; 155(4): 1287-90.
  14. Pierik F.H., Vreeburg T.M., Stijnen T., Van Roijen J.H., Dohle G.R., Laméris J.S. et al. Improvement of sperm count and motility after ligation of varicoceles detected with colour doppler ultrasonography. Int. J. Androl. 1998; 21(5): 256-60. https://dx.doi.org/10.1046 / j.1365-2605.1998.00123.x.
  15. Unal D., Yeni E., Verit A., Karatas O.F. Clomiphene citrate versus varicocelectomy in treatment of subclinical varicocele: a prospective randomized study. Int. J. Urol. 2001; 8(5): 227-30. https://dx.doi.org/10.1046/j.1442-2042.2001.00289.x.
  16. Ketabchi A.A., Ahmadinejad M., Ehsan M. Comparison of the effects of varicocelectomy on the spermiogram of patients with subclinical versus clinical varicocele. Acta Med. Iran. 2005; 43(4): 249-52.
  17. Cantoro U., Polito M., Muzzonigro G. Reassessing the role of subclinical varicocele in infertile men with impaired semen quality: a prospective study. Urology. 2015; 85(4): 826-30. https://dx.doi.org/10.1016 / j.urology.2015.01.015.
  18. Seo J.T., Kim K.T., Moon M.H., Kim W.T. The significance of microsurgical varicocelectomy in the treatment of subclinical varicocele. Fertil. Steril. 2010; 93(6): 1907-10. https://dx.doi.org/10.1016/j.fertnstert.2008.12.118.
  19. Kohn T.P., Ohlander S.J., Jacob J.S., Griffin T.M., Lipshultz L.I., Pastuszak A.W. The effect of subclinical varicocele on pregnancy rates and semen parameters: a systematic review and meta-analysis. Curr. Urol. Rep. 2018; 19(7): 53. https://dx.doi.org/10.1007/s11934-018-0798-8.
  20. Goldstein M., Gilbert B.R., Dicker A.P., Dwosh J., Gnecco C. Microsurgical inguinal varicocelectomy of the testis: an artery and lymphatic sparing technique. J. Urol. 1992; 148(6): 1808-11. https://dx.doi.org/10.1016/S0022-5347(17)37035-0.
  21. Marmar J.L., Kim Y. Subinguinal microsurgical varicocelectomy: a technical critique and statistical analysis of semen and pregnancy data. J. Urol. 1994; 152(4): 1127-32. https://dx.doi.org/10.1016/S0022-5347(17)32521-1.
  22. Kamal K.M., Jarvi K., Zini A. Microsurgical varicocelectomy in the era of assisted reproductive technology: influence of initial semen quality on pregnancy rates. Fertil. Steril. 2001; 75(5): 1013-6. https://dx.doi.org/10.1016/S0015-0282(01)01698-3.
  23. Jungwirth A., Gögüs C., Hauser W., Gomahr A., Schmeller N., Aulitzky W. et al. Clinical outcome of microsurgical subinguinal varicocelectomy in infertile men. Andrologia. 2001; 33(2): 71-4. https://dx.doi.org/10.1046/j.1439-0272.2001.00407.x.
  24. Diegidio P., Jhaveri J.K., Ghannam S., Hibbard J., Kosorok M., Hultman C.S. Review of current varicocelectomy techniques and their outcomes. BJU Int. 2011; 108(7): 1157-72. https://dx.doi.org/10.1111/j.1464-410X.2010.09959.x.
  25. Marmar J.L., DeBenedictis T.J., Praiss D. The management of varicoceles by microdissection of the spermatic cord at the external inguinal ring. Fertil. Steril. 1985; 43(4): 583-8. https://dx.doi.org/10.1016/s0015-0282(16)48501-8.
  26. Goldstein M., Gilbert B.R., Dicker A.P., Dwosh J., Gnecco C. Microsurgical inguinal varicocelectomy of the testis: an artery and lymphatic sparing technique. J. Urol. 1992; 148(6): 1808-11. https://dx.doi.org/10.1016/S0022-5347(17)37035-0.
  27. Seo J.T., Kim K.T., Moon M.H., Kim W.T. The significance of microsurgical varicocelectomy in the treatment of subclinical varicocele. Fertil. Steril. 2010; 93(6): 1907-10. https://dx.doi.org/10.1016/j.fertnstert.2008.12.118.
  28. Гамидов С.И., Авакян А.Ю. Роль субклинического варикоцеле в патогенезе идиопатической патозооспермии. Медицинский вестник Башкортостана. 2017; 12(3): 13-7. [Gamidov S.I., Avakyan A.Y. The role of subclinical varicocele in the pathogenesis of idiopathic pathozoospermia. Medical bulletin of Bashkortostan. 2017. Vol. 12. № 3. 69].
  29. Thirumavalavan N., Scovell J.M., Balasubramanian A., Kohn T.P., Ji B.,Hasan A. et al. The impact of microsurgical repair of subclinical and clinical varicoceles on total motile sperm count: is there a difference? Urology. 2018; 120: 109-13. https://dx.doi.org/10.1016/j.urology.2018.06.036.
  30. Cornud F., Belin X., Amar E., Delafontaine D., Hélénon O., Moreau J.F. Varicocele: strategies in diagnosis and treatment. Eur. Radiol. 1999; 9(3): 536-45. https://dx.doi.org/10.1007/s003300050706.
  31. Elbendary M.A., Elbadry A.M. Right subclinical varicocele: how to manage in infertile patients with clinical left varicocele? Fertil. Steril. 2009; 92(6): 2050-3. https://dx.doi.org/10.1016/j.fertnstert.2009.05.069.
  32. Zheng Y.Q., Gao X., Li Z.J., Yu Y.L., Zhang Z.G., Li W. Efficacy of bilateral and left varicocelectomy in infertile men with left clinical and right subclinical varicoceles: a comparative study. Urology. 2009; 73(6): 1236-40. https://dx.doi.org/10.1016/j.urology.2008.11.050.
  33. Sun X., Wang J., Peng Y., Gao Q., Song T., Yu W. et al. Bilateral is superior to unilateral varicocelectomy in infertile males with left clinical and right subclinical varicocele: a prospective randomized controlled study. Int. Urol. Nephrol. 2017; 50(2): 205-10. https://dx.doi.org/10.1007/s11255-017-1749-x.
  34. Niu Y., Wang D., Chen Y., Pokhrel G., Xu H., Wang T. et al. Comparison of clinical outcome of bilateral and unilateral varicocelectomy in infertile males with left clinical and right subclinical varicocele: a meta-analysis of randomised controlled trials. Andrologia. 2018; 50(9): e13078. https://dx.doi.org/10.1111/and.13078.

Received 14.09.2020

Accepted 02.10.2020

About the Authors

Nika D. Ahvlediani, Doctor of Medical Sciences, Professor of the Department of Urology, A.I Evdokimov Moscow State University of Medicine and Dentisty, Department of urology. Tel.: +7(903)590-09-17. E-mail: nikandro@mail.ru. 111398, Russia, Moscow, Kuskovskaya str., 1a-4.
Artem S. Chernushenko, urologist, A.I Evdokimov Moscow State University of Medicine and Dentisty, University Clinic “Kuskovo”, Moscow, Russia. Tel.: +7(495)713-90-90. E-mail: artemchernushenko@gmail.com. 111398, Russia, Moscow, Kuskovskaya str., 1a-4.
Igor A. Reva, Candidate of Medical Sciences, acting Head of the Department of Urology, A.I Evdokimov Moscow State University of Medicine and Dentisty, University Hospital “Kuskovo”, Moscow, Russia. Tel.: +7(495)713-90-90. E-mail: reva-igor@rambler.ru. 111398, Russia, Moscow, Kuskovskaya str., 1a-4.
Dmitry Yu. Pushkar, Academician of the Russian Academy of Sciences, Professor, Head of the Department of Urology, A.I Evdokimov Moscow State University of Medicine and Dentisty. Tel.:+7(495)713-90-90. E-mail: pushkardm@mail.ru. 127206, Russia, Moscow, Vucheticha str., 21.

For citation: Akhvlediani N.D., Chernushenko A.S., Reva I.A., Pushkar D.Yu. Subclinical varicocele: criteria for diagnosis, a role in the development of male infertility, a modern approach to treatment.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 11: 71-76 (in Russian).
https://dx.doi.org/10.18565/aig.2020.11.71-76

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