Antiphospholipid antibody profile, immunochemical properties, and diagnostic value in women with early recurrent spontaneous miscarriage

1. Бицадзе В.О., Хизроева Д.Х., Макацария Н.А., Егорова Е.С., Баймурадова С.М., Машкова Т.Я. Антифосфолипидные антитела, их патогенетическое и диагностическое значение при акушерской патологии. Акушерство, гинекология и репродукция. 2014; 8(2): 39-60. [Bitsadze V.O., Khizroeva D.Ch., Makatsaria N.A., Egorova E.S., Baymuradova S.M., Mashkova T.Ya. Antiphospholipid antibodies, their pathogenetic and diagnostic value in obstetric pathology. Obstetrics, gynecology, and Reproductology. 2014; 8 (2): 39-60. (in Russian)].
2. Cervera R. Antiphospholipid syndrome. Thromb. Res. 2017; 151(Suppl. 1): S43-7. https://dx.doi.org/10.1016/S0049-3848(17)30066-X.
3. Galarza-Maldonado C., Kourilovitch M.R., Perez-Fernandez O.M., Gaybor M., Cordero C., Cabrera S., Soroka N.F. Obstetric antiphospholipid syndrome. Autoimmun. Rev. 2012; 11(4): 288-95. https://dx.doi.org/10.1016/j.autrev.2011.10.006.
4. D'Ippolito S., Meroni P.L., Koike T., Veglia M., Scambia G., Di Simone N. Obstetric antiphospholipid syndrome: a recent classification for an old defined disorder. Autoimmun. Rev. 2014; 13(9): 901-8. https://dx.doi.org/10.1016/j.autrev.2014.05.004.
5. Менжинская И.В., Ванько Л.В. Патофизиологические механизмы развития акушерского антифосфолипидного синдрома. Акушерство и гинекология. 2018; 1: 5-12. [Menzhinskaya I.V., Van’ko L.V. Pathophysiological mechanisms of development of obstetric antiphospholipid syndrome. Obstetrics and Gynecology. 2018; 1: 5-12. (in Russian)]. https://dx.doi.org/10.18565/aig.2018.1.5-12.
6. Менжинская И.В., Ванько Л.В. Антифосфолипидные антитела как диагностические маркеры акушерского антифосфолипидного cиндрома. Акушерство и гинекология. 2019; 2: 5-12. [Menzhinskaya I.V., Vanko L.V. Antiphospholipid antibodies as diagnostic markers of obstetric antiphospholipid syndrome. Obstetrics and gynecology. 2019; 2: 5-12. (in Russian)]. https://dx.doi.org/10.18565/aig.2019.2.5-12.
7. Fialova L., Petráčková M., Kuchař O. Comparison of different enzyme-linked Immunosorbent assay methods for avidity determination of antiphospholipid antibodies. J. Clin. Lab. Anal. 2017; 31(6): e22121. https://dx.doi.org/10.1002/jcla.22121.
8. McDonnell T., Artim-Esen B., Wincup C., Ripoll V.M., Isenberg D., Giles I.P. et al. Antiphospholipid antibodies to domain I of beta-2-glycoprotein I show different subclass predominance in comparison to antibodies to whole beta-2-glycoprotein I. Front. Immunol. 2018; 9: 2244. https://dx.doi.org/10.3389/fimmu.2018.02244.
9. Cervera R., Conti F., Doria A., Iaccarino L., Valesini G. Does seronegative antiphospholipid syndrome really exist? Autoimmun. Rev. 2012; 11(8): 581-4. https://dx.doi.org/10.1016/j.autrev.2011.10.017.
10. Mekinian A., Bourrienne M.C., Carbillon L., Benbara A., Noémie A., Chollet-Martin S. et al. Non-conventional antiphospholipid antibodies in patients with clinical obstetrical APS: Prevalence and treatment efficacy in pregnancies. Semin. Arthritis Rheum. 2016; 46(2): 232-7. https://dx.doi.org/10.1016/j.semarthrit.2016.05.006.
11. Rodríguez-García V., Ioannou Y., Fernández-Nebro A., Isenberg D.A., Giles I.P. Examining the prevalence of non-criteria anti-phospholipid antibodies in patients ith anti-phospholipid syndrome: a systematic review. Rheumatology (Oxford). 2015; 54(11): 2042-50. https://dx.doi.org/10.1093/rheumatology/kev226.
12. Bertolaccini M.L., Amengual O., Atsumi T., Binder W.L., de Laat B., Forastiero R. et al. Non-criteria’ aPL tests: report of a task force and preconference workshop at the 13th International congress on antiphospholipid antibodies, Galveston, TX, USA, April 2010. Lupus. 2011; 20(2): 191-205. https://dx.doi.org/10.1177/0961203310397082.
13. Менжинская И.В., Кашенцева М.М., Ионанидзе Т.Б., Ванько Л.В., Сухих Г.Т. Спектр антифосфолипидных антител у женщин с привычным невынашиванием беременности и их диагностическое значение. Иммунология. 2016; 37(1): 4-9. [Menzhinskaya I.V., Kashentseva M.M., Ionanidze T.B., Vanko L.V., Sukhykh G.T. Spectrum of antiphospholipid antibodies in women with recurrent pregnancy loss and their diagnostic value. Immunology. 2016; 37 (1): 4-9. (in Russian)].
14. Čučnik S., Kveder T., Artenjak A., Ulcova Gallova Z., Swadzba J., Musial J. et al. Avidity of anti-beta2-glycoprotein I antibodies in patients with antiphospholipid syndrome. Lupus. 2012; 21(7): 764-5. https://dx.doi.org/10.1177/0961203312440057.
15. Alijotas-Reig J., Ferrer-Oliveras R., Ruffatti A., Tincani A., Lefkou E., Bertero M.T. et al. The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases. Autoimmun. Rev. 2015; 14(5): 387-95. https://dx.doi.org/10.1016/j.autrev.2014.12.010.
16. Clark C.A., Davidovits J., Spitzer K.A., Laskin C.A. The lupus anticoagulant: results from 2257 patients attending a high-risk pregnancy clinic. Blood. 2013; 122(3): 341-7; quiz 466. https://dx.doi.org/10.1182/blood-2013-02-485839.
17. Gardiner C., Hills J., Machin S.J., Cohen H. Diagnosis of antiphospholipid syndrome in routine clinical practice. Lupus. 2013; 22(1): 18-25. https://dx.doi.org/10.1177/0961203312460722.
18. Mekinian A., Loire-Berson P., Nicaise-Roland P., Lachassinne E., Stirnemann J., Boffa M.C. et al. Outcomes and treatment of obstetrical antiphospholipid syndrome in women with low antiphospholipid antibody levels. J. Reprod. Immunol. 2012; 94(2): 222-6. https://dx.doi.org/10.1016/j.jri.2012.02.004.
19. Meroni P.L., Chighizola C. Pathophysiology of the antiphospholipid syndrome (APS). Rev. Med. Interne. 2012; 33(Suppl. 2): A2-4. https://dx.doi.org/10.1016/j.revmed.2012.09.010.
20. Radin M., Cecchi I., Rubini E., Schreiber K., Roccatello D., Mahler M., Sciascia S. Prevalence and significance of anti-phosphatidylserine antibodies: a pooled analysis in 5992. Thromb. Res. 2018; 170: 28-31. https://dx.doi.org/10.1016/j.thromres.2018.07.031.
21. Agmon-Levin N., Seguro L., Rosario C., Mahler M., Gatto M., Tomer N. et al. Anti-β2GPI-DI antibodies are a marker of APS severity. Arthritis Rheum. 2013; 65(Suppl. 10, Special Issue): S1.
22. Yin D., Chayoua W., Kelchtermans H., de Groot P.G., Moore G.W., Gris J.-C. et al. Detection of anti-domain I antibodies by chemiluminescence enables the identification of high-risk antiphospholipid syndrome patients: A multicenter multiplatform study. J. Thromb. Haemost. 2020; 18(2): 463-78. https://dx.doi.org/10.1111/jth.14682.
23. Vidarsson G., Gillian Dekkers G., Rispens T. IgG subclasses and allotypes: from structure to effector functions. Front. Immunol. 2014; 5: 520. https://dx.doi.org/10.3389/fimmu.2014.00520.
24. Чепанов С.В., Шляхтенко Т.Н., Зайнулина М.С., Мирашвили М.И., Соколов Д.И., Сельков С.А. Антитела к аннексину V у женщин с привычным невынашиванием беременности. Акушерство и гинекология. 2014; 7: 29-32. [Chepanov S.V., Shlyakhtenko T.N., Zainulina M.S., Mirashvili M.I., Sokolov D.I., Selkov S.A. Antibodies to annexin V in women with recurrent pregnancy loss. Obstetrics and gynecology. 2014; 7: 29-32. (in Russian)].
25. Bećarević M. The IgG and IgM isotypes of anti-annexin A5 antibodies: relevance for primary antiphospholipid syndrome. J. Thromb. Thrombolysis. 2016; 42(4): 552-7. https://dx.doi.org/10.1007/s11239-016-1389-5.
26. Rand J.H., Wu X.X., Quinn A.S., Taatjes D.J. The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis. Lupus. 2010; 19(4): 460-9. https://dx.doi.org/10.1177/0961203310361485.
27. Conti F., Alessandri C., Sorice M., Capozzi A., Longo A., Garofalo T. et al. Thin-layer chromatography immunostaining in detecting anti-phospholipid antibodies in seronegative anti-phospholipid syndrome. Clin. Exp. Immunol. 2012; 167(3): 429-37. https://dx.doi.org/10.1111/j.1365-2249.2011.04532.x.
28. Sugi T. Kininogen-dependent antiphosphatidylethanolamine antibodies and autoantibodies to factor XII in patients with recurrent pregnancy loss. J. Obstet. Gynaecol. Res. 2013; 39(7): 1223-9. https://dx.doi.org/10.1111/jog.12110.
29. Amengual O., Forastiero R., Sugiura-Ogasawara M., Otomo K., Oku K., Favas C. et al. Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study. Lupus. 2017; 26(3): 266-76. https://dx.doi.org/10.1177/0961203316660203.
30. Kitaori T., Sugiura-Ogasawara M., Oku K, Papisch W., Ebara T., Ozaki Y. et al. Determination of clinically significant tests for antiphospholipid antibodies and cutoff levels for obstetric antiphospholipid syndrome. Lupus. 2015; 24(14): 1505-19. https://dx.doi.org/10.1177/0961203315595128.

Received 14.04.2020

Accepted 12.05.2020