Antiphospholipid antibodies as diagnostic markers for obstetric antiphospholipid syndrome

Menzhinskaya I.V., Vanko L.V.

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow
The authors have carried out a systems analysis of the data available in the current scientific literature on the spectrum and prevalence of antiphospholipid antibodies, their diagnostic and prognostic value in obstetric antiphospholipid syndrome. Detection techniques detection and the efficiency of using the antiphospholipid antibodies not included in the classification laboratory criteria for antiphospholipid syndrome in order to diagnose obstetric antiphospholipid syndrome are considered. The detection of the antiphospholipid antibody profile that includes anti-annexin A5 antibodies, the phosphatidylserine/prothrombin complex, phosphatidylethanolamine, and some negatively charged phospholipids contributes to the complete identification of patients with antiphospholipid syndrome and to the stratification of a risk for thrombosis and pregnancy complications. However, it is necessary to standardize these tests for practical use and to confirm the clinical significance of antiphospholipid antibodies in prospective studies.


obstetric antiphospholipid syndrome
laboratory criteria for antiphospholipid syndrome
antiphospholipid antibody profile


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Received 14.09.2018

Accepted 21.09.2018

About the Authors

Menzhinskaya, Irina V., PhD, senior researcher at the Clinical Immunology Laboratory, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail:
Vanko, Lyudmila V., MD, professor, leading researcher at the Clinical Immunology Laboratory, National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail:

For citations: Menzhinskaya I.V., Vanko L.V. Antiphospholipid antibodies as diagnostic markers for obstetric antiphospholipid syndrome. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2019; (2): 5-12. (in Russian)

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