Current concepts of the overactive bladder in women. Strategy for choosing drug therapy

DOI

https://dx.doi.org/10.18565/aig.2021.8.183-191

Romikh V.V., Zakharchenko A.V., Kukushkina L.Yu., Panteleev V.V., Romikh F.D.
N.A. Lopatkin Research Institute of Urology and Interventional Radiology, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

The overactive bladder (OAB) is one of the most important clinical conditions in functional urology for children and adults and а socially significant disease. About 18 million adults in our country are suspected to have OAB symptoms. Selective muscarinic receptor antagonists are considered to be the traditional treatment for OAB. Some mechanisms that lead to urgency are not suppressed by muscarinic receptor blockade. A new area of OAB pharmacotherapy is to affect β3-adrenoptors located in the bladder urothelium and suburothelium. After many years of studies, the innovative and unparalleled drug Mirabegron appeared, which was a β3-adrenomimetic that acts on the receptors of smooth muscle fibers. Mirabegron has a direct effect on the bladder urothelium.
Conclusion. According to some indicators, the efficacy of Mirabegron exceeds that of cholinolytics, whereas the clinical effect can be observed even in a group of patients with unsatisfactory results of previous treatment. Thus, Mirabegron can be considered as the drug of choice for OAB pharmacotherapy.

Кeywords: overactive bladder

imperative urinary incontinence

pharmacotherapy

urgency

urodynamic examination

urinary incontinence

lower urinary tract symptoms

Full text (in Russian)

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Received 03.06.2021

Accepted 17.06.2021

Victoria V. Romikh, Head of the Urodynamics and Neurourology Department, N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology –
Branch of the National Medical Research Centre of Radiology, Ministry of Health of Russian Federation. E-mail: vromikh@yandex.ru.
105425, Russia, Moscow, Parkovaya 3rd str., 51-1.
Alexey V. Zakharchenko, researcher of the Urodynamics and Neurourology Department, N.A. Lopatkin Scientific Research Institute of Urology and Interventional
Radiology – Branch of the National Medical Research Centre of Radiology, Ministry of Health of Russian Federation. E-mail: cor1@yandex.ru.
105425, Russia, Moscow, Parkovaya 3rd str., 51-1.
Ludmila Yu. Kukuskina, Junior Researcher of the Urodynamics and Neurourology Department, N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology, Ministry of Health of Russian Federation. E-mail: dr.kykyshkina@gmail.com.
105425, Russia, Moscow, Parkovaya 3rd str., 51-1.
Vladislav V. Panteleev, researcher of the Urodynamics and Neurourology Department, N.A. Lopatkin Scientific Research Institute of Urology and Interventional
Radiology – Branch of the National Medical Research Centre of Radiology, Ministry of Health of Russian Federation. E-mail: panteleev_vlad@mail.ru.
105425, Russia, Moscow, Parkovaya 3rd str., 51-1.
Filipp D. Romikh, Junior Researcher of the Urodynamics and Neurourology Department, N.A. Lopatkin Scientific Research Institute of Urology and Interventional
Radiology – Branch of the National Medical Research Centre of Radiology, Ministry of Health of Russian Federation. E-mail: phromikh@yandex.ru.
105425, Russia, Moscow, Parkovaya 3rd str., 51-1.

For citation: Romikh V.V., Zakharchenko A.V., Kukushkina L.Yu., Panteleev V.V., Romikh F.D. Current concepts of the overactive bladder in women. Strategy for choosing drug therapy.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2021; 8: 183-191 (in Russian).
https://dx.doi.org/10.18565/aig.2021.8.183-191

Current concepts of the overactive bladder in women. Strategy for choosing drug therapy

Romikh V.V., Zakharchenko A.V., Kukushkina L.Yu., Panteleev V.V., Romikh F.D.

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