Polycystic ovary syndrome in the presence of undifferentiated connective tissue dysplasia
Objective. To analyze the clinical, hormonal, and metabolic features of polycystic ovary syndrome (PCOS) in patients with undifferentiated connective tissue dysplasia (UCTD)Tereshchenko I.V.
Subjects and methods. The clinical, hormonal, and metabolic characteristics were analyzed in 87 patients of childbearing age with PCOS and UCTD.
Results. The observed patients had a normally low body weight, blood C-peptide and insulin levels, as well as HOMA IR and CARO indices in health. All had been previously treated with Metformin without any effect. Opsomenorrea, anovulation, and symptoms of hyperandrogenism occurred at menarche; abnormal ovarian morphology and the manifestations of UCTD increased with age.
Conclusion. In many cases, PCOS is concurrent with UCTD and is accompanied by abnormalities not only of the ovaries, but also of other organs. The patients do not have insulin resistance, obesity, or hypertriglyceridemia; it is inadvisable to use Metformin. At 5 weeks of embryogenesis when the hypothalamic-pituitary system, ovaries, and connective tissue are simultaneously laid, unfavorable genetic and/or environmental factors contribute to the occurrence of such a concurrent pathology.
Keywords
polycystic ovary syndrome
connective tissue dysplasia
opsomenorrea
hyperandrogenism
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Received 12.02.2020
Accepted 22.06.2020
About the Authors
Irina V. Tereshchenko, MD, Professor, endocrinologist of the MC «Professorial clinic». Tel.: +7(964)192-11-20. E-mail: i_v_t@bk.ru. ORCID: 0000-0002-0390-3649.15A Druzhby str., Perm, 614000, Russian Federation.
For citation: Tereshchenko I.V. Polycystic ovary syndrome in the presence of undifferentiated connective tissue dysplasia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 11: 184-189 (in Russian).
https://dx.doi.org/10.18565/aig.2020.11.184-189
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