The role of mitochondrial markers in the pathogenesis of preeclampsia and the evaluation of the efficiency of respiratory therapy in the treatment of preeclampsia
Objective. To carry out a systematic analysis of the data available in the current literature on the markers of preeclampsia and oxidative stress, as well as the impact of therapeutic methods on the development of preeclampsia.Skovorodina T.V., Vishnyakova P.A., Shmakov R.G., Vysokikh M.Yu.
Material and methods. The review included the data available in foreign and Russian articles published in the past 10 years and found in Pubmed on this topic.
Results. The paper describes the current markers of preeclampsia, such as endoglin, placental growth factor, soluble fms-like tyrosine kinase 1, and others, as well as immunological activators that have a marked proinflammatory effect (mitochondrial damage-associated molecular patterns (DAMPs)). It shows new treatments for gestational hypertension and pre-eclampsia by respiratory therapy (continuous positive airway pressure (CPAP)).
Conclusion. It is necessary to perform further investigations of the impact of mitochondrial DAMPs on the development of preeclampsia and to evaluate the efficiency of CPAP support in the treatment of preeclampsia.
Keywords
preeclampsia
markers
respiratory therapy
oxidative stress
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Received 16.12.2016
Accepted 23.12.2016
About the Authors
Skovorodina Tatyana Vyacheslavovna, Ph.D., Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia.117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: t_skovorodina@oparina4.ru
Vishnyakova Polina A., researcher at the Laboratory of mitochondrial medicine, Research Center of Obstetrics, Gynecology, and Perinatology,
Ministry of Health of the Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: vpa2002@mail.ru
Vysokikh Mikhail Yu., PhD, Head of mitochondrial medicine research group, Research Center of Obstetrics, Gynecology, and Perinatology,
Ministry of Health of the Russia. 117997, Russia, Moscow, Ac. Oparina str. 4. E-mail: m_vysokikh@oparina4.ru
Shmakov Roman G., chief physician, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia.
117997, Russia, Moscow Ac. Oparina str. 4. Tel.: +79255859171. E-mail: r_shmakov@oparina4.ru
For citations: Skovorodina T.V., Vishnyakova P.A., Shmakov R.G., Vysokikh M.Yu.
The role of mitochondrial markers in the pathogenesis of preeclampsia and the evaluation of the efficiency of respiratory therapy in the treatment of preeclampsia.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (6): 5-9. (in Russian)
http://dx.doi.org/10.18565/aig.2017.6.5-9
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