The feasibility of fertility-sparing treatment of young patients with recurrent endometrial cancer
Relevance. Endometrial cancer is the most prevalent gynecological cancer. About 2.9–14.4% of patients with endometrial cancer are aged below 40, and the incidence of cancer in this age group is on the rise. Most cases of endometrial cancer in women of this age are diagnosed at an early stage with no myometrial invasion and lymph node involvement. Therefore, such patients have a high cure rate, and for them, a quality of life is an extremely important outcome after treatment. Fertility preservation is one of the most important issues of long-term quality of life of cancer survivors of childbearing age.Babaeva N.A., Antonova I.B., Ivashina S.V., Aleshikova O.I., Lyustik A.V., Ashrafyan L.A.
Presentation A 33-year-old woman T. first presented with complaints of heavy menstrual bleeding. Her diagnostic evaluation included hysteroscopy and fractional curettage with a sampling of both the endometrial and the endocervical mucosa. Histopathological study revealed highly differentiated endometrial adenocarcinoma. Taking into account the patient’s age, nulliparous status and her desire to preserve fertility, conservative treatment was initiated.
Conclusion Conservative fertility-sparing treatment is highly effective in young patients with stage IA and G1 primary and recurrent endometrial adenocarcinoma. This treatment modality is safe and effective when applied to patients who met indications and most likely to comply with planned therapy.
Keywords
initial endometrial cancer
preservation of fertility
recurrence of endometrial cancer
hormonal therapy
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Received 19.12.2019
Accepted 27.12.2019
About the Authors
Nataliya A. Babaeva, MD, Leading Researcher, Department of Prevention, Comprehensive Diagnosis and Treatment of Gynecological Diseases, Federal State Budgetary Scientific Research Center of the Russian Ministry of Health, Moscow. E-mail: natbabaeva@yandex.ru. 117997, Russia, Moscow, ul. Profsoyuznaya, 86.Irina B. Antonova, MD, Head of the Department of Prevention, Comprehensive Diagnosis and Treatment of Gynecological Diseases, Federal State Budget Scientific Center of the Russian Center for Reconstruction and Development, Ministry of Health of the Russian Federation, Moscow. E-mail: natbabaeva@yandex.ru
117997, Russia, Moscow, ul. Profsoyuznaya, 86.
Svetlana V. Ivashina, Candidate of Medical Sciences, Senior Researcher, Department of Prevention, Comprehensive Diagnosis and Treatment of Gynecological Diseases, Federal State Budget Scientific Center, Scientific Center of the Russian Ministry of Health, Moscow. E-mail: s.ivashina@bk.ru. 117997, Russia, Moscow, ul. Profsoyuznaya, 86.
Olga I. Aleshikova, Candidate of Medical Sciences, Senior Researcher, Department of Prevention, Comprehensive Diagnosis and Treatment of Gynecological Diseases, Federal State Budgetary Scientific Research Center of the Russian Ministry of Health, Moscow. E-mail: s.ivashina@bk.ru Тел.: +7 (499) 120-60-77. E-mail: olga.aleshikova@gmail.com
117997, Russia, Moscow, ul. Profsoyuznaya, 86.
Anna V. Lyustik, candidate of medical sciences, junior researcher, department of prevention, comprehensive diagnosis and treatment of gynecological diseases Federal State Budgetary Institution “Russian Scientific Center of X-Ray Radiology” of the Ministry of Health of the Russian Federation.117997, Russia, Moscow, ul. Profsoyuznaya, 86.
Levon A. Ashrafyan, Academician of the Russian Academy of Sciences, Director of the Institute of Oncogynecology and Mammology, Federal State Budgetary Institution “National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov”, Chief Researcher, Department of Prevention, Comprehensive Diagnosis and Treatment of Gynecological Diseases, Federal State Budget Scientific Center of the Russian Center for Reconstruction and Human Rights, Moscow. Phone: +7 (495) 531-44-44. E-mail: levaa2004@yahoo.com. 117997, Russia, Moscow, ul. Profsoyuznaya, 86.
For citation: Babaeva N.A., Antonova I.B., Ivashina S.V., Aleshikova O.I., LyustikA.V., Ashrafyan L.A. The feasibility of fertility-sparing treatment of young patients with recurrent endometrial cancer.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2020; 1(Suppl): 130-6. (in Russian).
https://dx.doi.org/10.18565/aig.2020.1suppl.130-136
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