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The Journal "Obstetrics and Gynecology"Journal HistoryAims and ScopePolicies on Conflict of Interest, Human and Animal Rights, and Informed ConsentEditorial ProcessData sharing statementAdvertising PolicyThe Process for Handling Cases Requiring Corrections, Retractions, and Editorial Expressions of ConcernEditorial BoardEditorial CounsilInformation for ProfessionalsNewsContacts
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Obstetrics and Gynegology2023№12
Endometrial cancer and pregnancy

Endometrial cancer and pregnancy

DOI
https://dx.doi.org/10.18565/aig.2023.178

Chernyakov A.A., Chernyshova A.L., Kolomiets L.A., Truschuk Yu.M., Dil O.S., Krasilnikov S.E., Antipov V.A., Shumeikina A.O., Chernyshova A.E.

1) Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia; 2) E.N. Meshalkin National Medical Research Center, Ministry of Health of Russia, Novosibirsk, Russia; 3) St. Petersburg State University, St. Petersburg, Russia

Objective: To summarize the current data on the combination of endometrial cancer and pregnancy, including risk factors, pathogenetic mechanisms and management options for patients.
Materials and methods: The databases and services, namely PubMed, Wiley, Scopus and Google scholar have been searched for the articles on the association of pregnancy and endometrial cancer over the past 12 years.
Results: The article presents the analysis of the modern literature on the incidence, possible mechanisms of pathogenesis and characteristics of the clinical course of endometrial cancer associated with pregnancy. The main risk factors typical for this pathology which were highlighted in various studies are presented. The studies of foreign scientists reviewing the molecular genetic and transcriptional profiles of endometrial malignancies during pregnancy are analyzed. The role of chorionic gonadotropin in the pathogenesis of endometrial cancer is also identified. Since this pathology affects the organ necessary for pregnancy and actually reduces a woman’s reproductive potential, it becomes obvious that cancer of the uterine body is not only an important medical problem, but it is also a social issue in the modern world. The combination of endometrial cancer and pregnancy is a rare case, its incidence is 1% and it is characterized by a favorable course and prognosis.
Conclusion: Endometrial cancer associated with pregnancy is rather a rare pathology and it is characterized by a favorable course and prognosis. There are no cases of cancer progression during pregnancy in the literature. However, the mechanisms of the protective effect of this physiological condition have not been studied enough, thus, it is necessary to continue research in this direction.

Authors’ contributions: Chernyakov A.A. – work with literature, writing an article; Chernyshova A.L. – developing the subject of the review, writing an article, working with literature; Kolomiets L.A. – work with literature, adding relevant comments; Truschuk Yu.M., Dil O.S., Krasilnikov S.E., Antipov V.A., Shumeikina A.O. – work with literature; Chernyshova A.E. – analysis and translation of the articles.
Conflicts of interest: Authors declare lack of the possible conflicts of interests.
Funding: The study was conducted without sponsorship.
For citation: Chernyakov A.A., Chernyshova A.L., Kolomiets L.A., Truschuk Yu.M., Dil O.S., Krasilnikov S.E., Antipov V.A., Shumeikina A.O., Chernyshova A.E.Endometrial cancer and pregnancy. 
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (12): 40-46 (in Russian)
https://dx.doi.org/10.18565/aig.2023.178

Keywords

endometrial cancer
pregnancy
prognosis
survival
Full text (in Russian)

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Received 25.07.2023

Accepted 04.12.2023

About the Authors

Alexander A. Chernyakov, resident physician, Research Institute of Oncology, Tomsk National Research Medical Centre of the Russian Academy of Sciences,
а.cherniаckow@yаndex.ru, Author ID (Scopus): 1172939, SPIN Code: 6269-5998. https://orcid.org/0000-0003-0829-0340, 634009, Russia, Tomsk, Kooperativny per. 5.
Alena L. Chernyshova, Dr. Med. Sci., Professor of the RAS, Chief Researcher, Department of Gynecology, Research Institute of Oncology, Tomsk National Research Medical Centre of the Russian Academy of Sciences, аlасhеr@list.ru, Author ID (Scopus): 55220758100, Reseacher ID (WOS): C-8608-2012, SPIN code: 2522-7513,
https://orcid.org/0000-0002-8194-2811, 634009, Russia, Tomsk, per. Kooperativny, 5.
Larisa A. Kolomiets, Dr. Med. Sci., Professor, Head of the Department of Gynecology, Research Institute of Oncology, Tomsk National Research Medical Centre of the Russian Academy of Sciences, Author ID (Scopus): 7004921120. Reseacher ID (WOS): C-8573-2012, https://orcid.org/0000-0002-6854-8940, 634009, Russia, Tomsk,
per. Kooperativny, 5.
Yulia M. Trushuk, doctor, Oncology Department No. 4, Research Institute of Oncology, Tomsk National Research Medical Centre, Russian Academy of Sciences,
julija-bilina@mail.ru, Author ID (Scopus): 1142135, SPIN code: 9852-3387, https://orcid.org/0000-0001-5926-2601, 634009, Russia, Tomsk, per. Kooperativny, 5.
Olga S. Dil, resident physician, Research Institute of Oncology, Tomsk National Research Medical Centre of the Russian Academy of Sciences, lyаbishevа.os@mаil.ru,
Аuthor ID (Scopus): 1142135, SPIN code: 7265-4352, https://orcid.org/0000-0001-6562-7574, 634009, Russia, Tomsk, per. Kooperativny, 5.
Sergey E. Krasilnikov, Dr. Med. Sci., Professor, Director, Academician E.N. Meshalkin National Medical Research Centre, Ministry of Health of the Russian Federation, professorkrasilnikov@rambler.ru, https://orcid.org/0000-0003-0687-0894, 630055, Russia, Novosibirsk, Rechkunovskaya str., 15.
Vitaly A. Antipov, Dr. Med. Sci., Academician E.N. Meshalkin National Medical Research Centre, Ministry of Health of the Russian Federation, Author ID (Scopus): 7005104470; https://orcid.org/0000-0003-3522, 630055, Russia, Novosibirsk, Rechkunovskaya str., 15.
Anastasia O. Shumeikina, oncologist, Academician E.N. Meshalkin National Medical Research Centre, Ministry of Health of the Russian Federation, +7(999)464-01-63, nashum99@mail.ru, 630055, Russia, Novosibirsk, Rechkunovskaya str., 15.
Arina E. Chernyshova, student, Faculty of Medicine, St. Petersburg State University, 199034, Russia, St. Petersburg, Universitetskaya naberezhnaya, 7/9.
Corresponding author: Alena L. Chernyshova, alacher@list.ru

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