Implementation of an assisted reproductive technology program in a liver transplant patient
Background. Current advances in organ transplantation and active development in pharmaceutical industry allow women with organ transplants to spontaneously carry a pregnancy and give birth to babies today. Taking into account the fact that these patients may have a reduced reproductive potential due to the underlying disease, some cases need assisted reproductive technology (ART) to achieve pregnancy. However, there are features in the preparation and management of patients with organ transplants within the IVF program and their subsequent monitoring during pregnancy.Belyaeva N.A., Kalinina E.A., Smolnikova V.Yu., Makarova N.P.
Clinical case report. The paper describes a clinical case of a 28-year-old patient with a liver transplant who has received an ART program and given birth to a healthy baby.
Conclusion. Accumulated clinical experience with ART programs in women with organ transplants will be able to optimize approaches to treating infertility in these patients by minimizing maternal and fetal risks.
Keywords
in vitro fertilization
intracytoplasmic sperm injection
organ transplantation
pregnancy
Supplementary Materials
References
1. Kanzaki Y., Kondoh E., Kawasaki K., Mogami H., Chigusa Y., Konishi I. Pregnancy outcomes in liver transplant recipients: A 15-year single-center experience. Obstet. Gynaecol. Res. 2016; 42(11): 1476-82. doi: 10.1111/jog.13096.
2. Li Y.P., Shih J.C., Lin S.Y., Lee C.N. Pregnancy outcomes after kidney transplantation-A single-center experience in Taiwan. Taiwan J. Obstet. Gynecol. 2016; 55(3): 314-8.
3. Majak G.B., Sandven I., Lorentzen B., Vangen S., Reisaeter A.V., Henriksen T., Michelsen T.M. Pregnancy outcomes following maternal kidney transplantation: a national cohort study. Acta Obstet. Gynecol. Scand. 2016; 95(10): 1153-61. doi: 10.1111/aogs.12937.
4. Ghazali S., Czuzoj-Shulman N., Spence A.R., Mishkin D.S., Abenhaim H.A. Pregnancy outcomes in liver transplant patients, a population-based study. J. Matern. Fetal Neonatal Med. 2016; 30(3): 261-6.
5. Norrman E., Bergh C., Wennerholm U.B. Pregnancy outcome and long-term follow-up after in vitro fertilization in women with renal transplantation. Hum. Reprod. 2015; 30(1): 205-13.
6. Pietrzak B., Mazanowska N., Kociszewska-Najman B., Szymusik I., Grzechocińska B., Pazik J. et al. Successful pregnancy outcome after in vitro fertilization in a kidney graft recipient: A case report and literature review. Ann. Transplant. 2015; 20: 338-41.
7. Lockwood G.M., Ledger W.L., Barlow D.H. Successful pregnancy outcome in a renal transplant patient following in-vitro fertilization. Hum. Reprod. 1995; 10(6): 1528-30.
8. Furman B., Wiznitzer A., Hackmon R., Gohar J., Mazor M. Multiple pregnancies in women after renal transplantation. Case report that rises a management dilemma. Eur. J. Obstet. Gynecol. Reprod. Biol. 1999; 84(1): 107-10.
9. Case A.M., Weissman A., Sermer M., Greenblatt E.M. Successful twin pregnancy in a dual-transplant couple resulting from in-vitro fertilization and intracytoplasmic sperm injection: case report. Hum. Reprod. 2000; 15(3): 626-8.
10. Khalaf Y., Elkington N., Anderson H., Taylor A., Braude P. Ovarian hyperstimulation syndrome and its effect on renal function in a renal transplant patient undergoing IVF treatment: case report. Hum. Reprod. 2000; 15(6): 1275-7.
11. Tamaki M., Ami M., Kimata N., Tsutsui T., Watanabe Y., Saito T. et al. Successful singleton pregnancy outcome resulting from in vitro fertilization after renal transplantation. Transplantation. 2003; 75(7): 1082-3.
12. Ulug U., Mesut A., Jozwiak E.A., Bahceci M. Successful pregnancy in a liver transplant recipient following controlled ovarian hyperstimulation and intracytoplasmic sperm injection. J. Assist. Reprod. Genet. 2005; 22(7-8): 311-3.
13. Fichez A., Labrousse C., Fromajoux C., Bordes A., Hadj S., Audra P., Salle B. Successful pregnancy outcome after in vitro fertilization in a pancreas-kidney recipient. Fertil. Steril. 2008; 90(3): 849. e1-3.
14. Nouri K., Bader Y., Helmy S., Ott J., Jirecek S., Tempfer C.B. Live birth after in vitro fertilization and single embryo transfer in a kidney transplant patient: a case report and review of the literature. J. Assist. Reprod. Genet. 2011;28(4): 351-3.
Received 25.08.2016
Accepted 02.09.2016
About the Authors
Belyaeva N.A., researcher of B.V. Leonov Department of assistive reproductive technology in the treatment of infertility, Research Center of Obstetrics, Gynecology, and Perinatology. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +79653435500. E-mail: dr_belyaeva@mail.ruKalinina E.A., M.D., Ph.D., Head of B.V. Leonov Department of assistive reproductive technology in the treatment of infertility, Research Center of Obstetrics, Gynecology, and Perinatology. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74955314444. E-mail: e_kalinina@oparina4.ru
Smolnikova V.Y., M.D., Ph.D., principal scientist of B.V. Leonov Department of assistive reproductive technology in the treatment of infertility, Research Center of Obstetrics, Gynecology, and Perinatology. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74955314444. E-mail: veronika.smolnikova@mail.ru
Makarova Natalia Petrovna, Cand. Sc. (Biology), Senior Researcher, B.V. Leonov Department of assistive reproductive technology in the treatment of infertility,
Research Center of Obstetrics, Gynecology, and Perinatology. 117997, Russia, Moscow, Ac. Oparina str. 4. Tel.: +74955314444
For citations: Belyaeva N.A., Kalinina E.A., Smolnikova V.Yu., Makarova N.P. Implementation of an assisted reproductive technology program in a liver transplant patient. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (6): 170-4. (in Russian)
http://dx.doi.org/10.18565/aig.2017.6.170-4
Similar Articles
