Prognostic value in determining the maternal autoantibodies during pregravid preparation, which affect the development of autism spectrum disorder in a baby
Objective. To evaluate the diagnostic and prognostic capabilities of analyzing the profiles of serum immunoreactivity defined by a number of autoantibodies for the identification of women at risk of having a baby with autism spectrum disorder (ASD).Torchinov A.M., Tsakhilova S.G., Kuznetsov V.P., Khmelnitskaya A.V., Poletaev A.B.
Material and methods. The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to investigate serum from mothers given birth to ASD babies and healthy ones.
Results. The paper describes the most common disorders and complications occurring in the group of women who have given birth to a baby with ASD (a compromised somatic and obstetric/gynecological history), as well as their characteristic changes in the profiles of serum immunoreactivity. It discusses whether there may be a relationship between maternal immunoregulatory disorders and fetal malformations.
Conclusion. The modified production of some maternal IgG autoantibodies that are tropic to antigens of the nervous system and to those of a number of somatic organs (detected by ELI-Viscero-Test and ELI-Neuro-Test) may be a decisive pathogenic factor leading to ASD in her baby.
Keywords
pregnancy
maternal immune disorders
maternal immune imprinting
environmental factors
autoantibodies
autism spectrum disorder
ELI-Viscero-Test
ELI-Neuro-Test
Supplementary Materials
- Table 1. Anomalies of profiles of immunoreactivity in mothers , who gavebirth to children with autism , and mothers who gave birth to children without neuropathology according to ELI-Viscero-Test
- Table 2. Results of "ELI-Neuro-Test" in mothers who gave birth to children with autism spectrum disorder , and mothers who gave birth to children without signs of somatic and neurological disorders
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Received 09.06.2017
Accepted 23.06.2017
About the Authors
Torchinov Amirhan M., MD, professor, Head of the Department of obstetrics and gynecology, stomatological faculty, A.I. Evdokimov Moscow State Universityof Medicine and Dentistry, Ministry of Health of Russia. 127473, Russia, Moscow, Delegatskaya str. 20, bld. 1. Tel.: +79268000600. E-mail: antonina.zanilova@gmail.com
Tcakhilova Svetlana G., MD, professor, Department of obstetrics and gynecology, stomatological faculty, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia; Deputy chief physician for medical part of the Maternity Home Eight, Branch, City Clinical Hospital Sixty-Eight.
109507, Russia, Moscow, Samarkandskyii bulvar 3. Tel.: +79167944730. E-mail: dzh2010@mail.ru
Kuznetsov Vadim P., MD, Deputy chief physician for medical part of the Maternity Home Eight, Branch, City Clinical Hospital Sixty-Eight; Department of obstetrics and gynecology, stomatological faculty, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia.
109507, Russia, Moscow, Samarkandskyii bulvar 3. Tel.: +74957090109. E-mail: rd8@68gkb.ru
Khmelnitskaya Antonina V., Obstetrician-gynecologist, a Maternity Home Eight, Branch, City Clinical Hospital Sixty-Eight; Department of obstetrics and gynecology, stomatological faculty, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia.
109507, Russia, Moscow, Samarkandskyii bulvar 3. Tel.: +79251995090. E-mail: antonina.zanilova@gmail.com
Poletaev Alexandr B., MD, professor, Scientific Director, Immunkulus Medical Research Center; P.K. Anokhin Research Institute of Normal Physiology.
105187 Russia, Moscow, Okruzhnoi proezd 30A. Tel.: +79250811638. E-mail: a-b-poletaev@yandex.ru
For citations: Torchinov A.M., Tsakhilova S.G., Kuznetsov V.P., Khmelnitskaya A.V., Poletaev A.B. Prognostic value in determining the maternal autoantibodies during pregravid preparation, which affect the development of autism spectrum disorder in a baby. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2017; (12): 60-6. (in Russian)
https://dx.doi.org/10.18565/aig.2017.12.60-66
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