Application of assisted reproductive technology programs in a female patient with systemic lupus erythematosus and antiphospholipid syndrome
Background. Patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) often face the problems related to their reproductive function; in this connection many patients undergo assisted reproductive technology (ART) programs. However, the challenges in implementing the ART programs in this group of patients include diminished ovarian reserve due to the treatment received, as well as the risk of an exacerbation of the underlying disease and thrombosis.Kosheleva N.M., Perminova S.G., Vlasova G.A., Kirillova A.O.
Case report. This describes a case of a successfully implemented in vitro fertilization (IVF) program, followed by embryo cryopreservation in the patient with severe SLE and APS and a family obstetric/gynecological history.
Conclusion. The authors describe the stages of the IVF program in the modified clinical and embryological protocol for ovarian stimulation with gonadotropin-releasing hormone antagonists and subsequent embryo cryopreservation, as well as the measures to prevent complications of the underlying disease.
Keywords
systemic lupus erythematosus
antiphospholipid syndrome
infertility
assisted reproductive technologies
in vitro fertilization
thrombosis
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Received 04.02.2020
Accepted 07.02.2020
About the Authors
Nadezhda M. Kosheleva, MD, Rheumatologist, PhD, Senior scientific researcher of the Laboratory of Vascular Rheumatology, V.A. Nasonova Research Rheumatology Institute. Tel.: +7(495)109-29-10. E-mail:nadkosheleva@yandex.ru.34A, Kashirskoye Shosse, Moscow, 115522, Russian Federation.
Svetlana G. Perminova, MD, PhD, Leading researcher of 1-st gynecology department, Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. Tel.: +7(916)202-16-87. E-mail: perisvet@list.ru.
4, Oparina str., Moscow, 117997, Russian Federation.
Galina A. Vlasova, graduate student of 1-st gynecology department, Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov.
Tel.: +7(906)079-44-49. E-mail: galinavlasova089@gmail.com.
4, Oparina str., Moscow, 117997, Russian Federation.
Anastasia O. Kirillova, PhD, Senior researcher, 1-st gynecology department, Research Center of Obstetrics, Gynecology and Perinatology named
after Academician V.I. Kulakov. Tel.: +7(926)781-55-24. E-mail: a_kozyreva@oparina4.ru. 4, Oparina str., Moscow, 117997, Russian Federation. 18
For citation: Kosheleva N.M., Perminova S.G., Vlasova G.A., A.O. Kirillova A.O. Application of assisted reproductive technology programs in a female patient with systemic lupus erythematosus and antiphospholipid syndrome.
Akusherstvo i Ginekologiya/ Obstetrics and gynecology. 2020; 4: 224-229. (In Russian).
https://dx.doi.org/10.18565/aig.2020.4.224-229
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