Use of platelet-rich autoplasma in the assisted reproductive technology programs

Zabrodina Yu.V., Akhmediyanova G.U., Khamidullina Z.G.

Medical University of Astana, Astana, Kazakhstan
To date, the use of platelet-rich autoplasma (PRA) has become one of the new areas used in the assisted reproductive technology programs. Platelets contain a large number of growth factors and different types of proteins that are released after their activation. These factors accelerate cell mitosis, promote angiogenesis of endothelial cells, induce anti-inflammatory modulators, and support the production of fibrinogen that is essentially a framework for tissue regeneration. The intraovarial and intrauterine PRA administration has been used in reproductive medicine for the thin endometrium, premature ovarian insufficiency, and a low ovarian reserve.
In preparing this review, we sought literature over the past 10 years to identify studies on the use of PRA therapy in the assisted reproductive technology programs.
Conclusion: The use of PRA is a new and rather promising method for infertility treatment in some women who are resistant to standard therapy. However, there is a need for additional prospective randomized controlled trials involving more participants to more significantly demonstrate the benefits of PRA therapy in clinical practice.

Authors' contributions: All authors have equally participated in the writing this article. Zabrodina Yu.V., Akhmediyanova G.U., Khamidullina Z.G. – material collection and processing, writing the text, editing.
Conflicts of interest: The authors of the article declare that there are no conflicts of interest.
Funding: The investigation has not been sponsored.
For citation: Zabrodina Yu.V., Akhmediyanova G.U., Khamidullina Z.G. Use of platelet-rich autoplasma in the assisted reproductive technology programs.
Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2023; (7): 5-11 (in Russian)


PRA therapy
platelet-rich plasma
assisted reproductive technologies
in vitro fertilization
PRA and thin endometrium
PRA and low ovarian reserve


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Received 09.03.2023

Accepted 19.06.2023

About the Authors

Yuliya V. Zabrodina, Doctoral Candidate, 2nd year, specialty "Medicine", Astana Medical University, Astana, Kazakhstan, +77051151200, +77751655716,,, Astana, Saryarka str., 11, 126, Republic of Kazakhstan, 010000
Gainyl U. Akhmediyanova, PhD, Professor, Obstetrics and Gynecology Department One, Astana Medical University, Astana, Kazakhstan,
Zaituna G. Khamidullina, PhD, Head of the Obstetrics and Gynecology Department One, Astana Medical University, Astana, Kazakhstan,
Corresponding author: Yuliya V. Zabrodina,

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