Use of autologous platelet­rich plasma in infertility and miscarriage

Kovalev M.V., Vartanyan E.V., Dobrokhotova Yu.E., Tsaturova K.A., Devyatova E.A.

1) Department of Obstetrics and Gynecology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia; 2) “Test-Tube Baby” Clinic of Assisted Reproductive Technologies, Moscow, Russia
The paper reviews the data available in modern foreign and Russian literature on the practical use of autologous platelet-rich plasma (PRP) in patients with infertility. It reflects the main directions, key aspects, duration and level of clinical trials studying PRP and considers a range of effects of the technology used in clinical practice. PRP is noted to be of value in correcting infertility-accompanying pathological conditions, including chronic endometritis, as well as in applying assisted reproductive technologies. The paper is aimed at finding solutions to the problem associated with fertility restoration in women with the functionally defective endometrium.
Conclusion. The results of scientific research obtained to date may suggest that the use of PRP may become a promising treatment after recurrent implantation failures in IVF programs, but also that of patients with miscarriage.


autologous platelet-rich plasma
chronic endometritis


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Received 07.05.2020

Accepted 05.06.2020

About the Authors

Maxim V. Kovalev, hematologist, obstetrician-gynecologist, LLC “Test-Tube Babies” Clinic for Assisted Reproductive Technologies.
Tel.: +7(495)981-85-80. E-mail: ORCID: 0000-0002-1095-4700. eLibrary SPIN-code: 6645-5193. 123182, Russia, Moscow, Shchukinskaya str., 2.
Emma V. Vartanyan, MD, Assistant Professor, Professor of the Department of Obstetrics and Gynecology, N.I. Pirogov Russian National Research Medical University; President of the self-regulating society Association of ART Clinics, Director of LLC “Test-Tube Babies” Clinic for Assisted Reproductive Technologies, obstetrician-gynecologist, reproductive specialist. Tel.: +7(495)981-85-80. E-mail: ORCID: 0000-0003-0337-086X. eLibrary SPIN- code: 7922-7936.
123182, Russia, Moscow, Shchukinskaya str., 2.
Yulia E. Dobrohotova, MD, Professor, Chief of the Department of Obstetrics and Gynecology, N.I. Pirogov Russian National Research Medical University.
Tel.: +7(495)434-36-90. E-mail: ORCID: 0000-0002-7830-2290, eLibrary SPIN- code: 2925-9948, Scopus Author ID: 57188592250.
117997, Russia, Moscow, Ostrovityanova str., 1.
Kristina A. Tsaturova, PhD, Chief of LLC “Test-Tube Babies” Clinic for Assisted Reproductive Technologies, obstetrician-gynecologist, reproductive specialist.
Tel.: +7(495)981-85-80. E-mail: ORCID: 0000-0002-1095-4700. eLibrary SPIN- code: 6645-5193. 123182, Russia, Moscow, Shchukinskaya str., 2.
Ekaterina A. Devyatova, MD, doctor of ultrasound diagnostics, obstetrician-gynecologist, LLC “Test-Tube Babies” Clinic for Assisted Reproductive Technologies.
Tel.: +7(495)981-85-80. E-mail: ORCID: 0000-0003-1533-1593. eLibrary SPIN- code: 1298-3699. 123182, Russia, Moscow, Shchukinskaya str., 2.1

For citation: Kovalev M.V., Vartanyan E.V., Dobrokhotova Yu.E., Tsaturova K.A., Devyatova E.A. Use of autologous platelet-rich plasma in infertility and miscarriage.
Akusherstvo i Ginekologiya/ Obstetrics and Gynecology. 2020; 11: 33-38 (in Russian).

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